Cell signalling
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- Interview with Cancer Informatics editorial board member Dr Grant Izmirlian
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- 22/Sep/2009
- Sponsor the IBM-OCI Integrative Discovery team in Ride to Conquer Cancer
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- 15/Sep/2009
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- 15/Sep/2009
- Newsletter summary (week 36, 2009)
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- 15/Sep/2009
- Interview with Healthy Aging and Clinical Care in the Elderly editorial board member Dr Davide Malatesta
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- 15/Sep/2009
- Interview with Translational Oncogenomics author Dr David Frank
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- 10/Sep/2009
- Interview with Retrovirology: Research and Treatment author Dr Elcio Leal
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- 10/Sep/2009
- Interview with Microbiology Insights author Dr Tinatin Doolotkedlieva
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- 10/Sep/2009
- Call for papers for Drug Target Insights by Dr Monica Milani
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- 10/Sep/2009
- Call for papers for Clinical Medicine: Urology from Dr Xiangyi Lu
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- 10/Sep/2009
- Research profile on Gene Regulation and Systems Biology author Dr Noboru Uchide
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- 09/Sep/2009
- Interview with Biomarker Insights editorial board member Dr Lawrence Cheskin
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- 07/Sep/2009
- Newsletter summary (week 35, 2009)
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- 04/Sep/2009
- Research profile of Clinical Medicine: Endocrinology and Diabetes author Dr Hiro Koshiyama
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- 04/Sep/2009
- Open access articles published in August
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- 03/Sep/2009
- Call for papers for Clinical Medicine: Circulatory, Respiratory and Pulmonary Medicine from Dr Hussein Foda
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- 03/Sep/2009
- Interview with Cancer Informatics editorial board member Dr Georgios S. Stamatakos
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- 03/Sep/2009
- Announcing mobile Libertas Academica website
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- Call for papers for Particle Physics Insights from Dr Hanna Moussa
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- 02/Sep/2009
- Call for papers for Clinical Medicine: Dermatology from Dr Robert Pearl
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- 01/Sep/2009
- Interview with Immunotherapy Insights editorial board member Dr Stéphanie McArdle
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- 01/Sep/2009
- Interview with Cell Communication Insights editorial board member Dr John S Torday
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- 01/Sep/2009
- Interview with Translational Oncogenomics editorial board member Dr James Connor
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- 31/Aug/2009
- Interview with Glycobiology Insights editorial board member Dr Alberto Passi
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- 31/Aug/2009
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Latest articles
- Left Ventricular Rupture Post Mitral Valve Replacement
- Graphical User Interfaces for Molecular Dynamics—Quo Vadis?
- Pharmacotherapy of Chronic Obstructive Pulmonary Disease: Focus on Arformoterol Tartrate
- A Review of Sildenafil in the Treatment of Pediatric Pulmonary Arterial Hypertension
- Impact of One-Year Methadone Maintenance Treatment in Heroin Users in Jiangsu Province, China
- Bioremediation of Bisphenol A and Benzophenone by Glycosylation with Immobilized Marine Microalga Pavlova sp.
- Metabolic Complications of Bypass Surgery for Morbid Obesity
- Collaboration to Meet a Therapeutic Need: The Development of Nelarabine
- Taxonomy of Bacteria Nodulating Legumes
- Hemangioma of the Thyroid
- Good News from Aliskiren?
- The Influence of Traditional Herbal Medicine (Kampo) on Anti-cyclic Citrullinated Peptide Antibody Levels
- Present and Prospective Pharmacotherapies in Pulmonary Arterial Hypertension
- Tigecycline in the Treatment of Community-Acquired Pneumonia
- Pharmacotherapy of Chronic Hepatitis B in Adults: Focus on Tenofovir Disoproxil Fumarate
- Stress Cardiomyopathy (Takotsubo Cardiomyopathy)
- Safety and Efficacy of Didanosine Enteric-Coated Capsule in Patients with HIV-1 Infection
- Anatomical and Functional Organization of Inhibitory Circuits in the Songbird Auditory Forebrain
- Aliskiren for the Treatment of Hypertension: An Update
- Montelukast: Pharmacology, Safety, Tolerability and Efficacy
Most read articles
- Current Status of Monocyte Differentiation-Inducing (MDI) Factors Derived from Human Fetal Membrane Chorion Cells Undergoing Apoptosis after Infl uenza Virus Infection
- Relationship Between the Plasma Concentration of C-Reactive Protein and Severity of Peripheral Arterial Disease
- Intraspecific ITS Variability in the Kingdom Fungi as Expressed in the International Sequence Databases and Its Implications for Molecular Species Identification
- A Simple Derivation of the Distribution of Pairwise Local Protein Sequence Alignment Scores
- Mammoth and Elephant Phylogenetic Relationships: Mammut Americanum, the Missing Outgroup
- DICOM Structured Reporting and Cancer Clinical Trials Results
- Evaluation of Two Outlier-Detection-Based Methods for Detecting Tissue-Selective Genes from Microarray Data
- Systems Biology-Based Identification of Crosstalk between E2F Transcription Factors and the Fanconi Anemia Pathway
- Exploring the Evolutionary History of the Differentially Expressed Genes between Human Populations: Action of Recent Positive Selection
- On the Adaptive Design Rules of Biochemical Networks in Evolution
- Fast Genes and Slow Clades: Comparative Rates of Molecular Evolution in Mammals
- Phylogenetic diversity (PD) and biodiversity conservation: some bioinformatics challenges
- Identification and Quantitation of Asparagine and Citrulline Using High-Performance Liquid Chromatography (HPLC)
- Identification of Conflicting Selective Effects on Highly Expressed Genes
- In Silico Promoter Analysis can Predict Genes of Functional Relevance in Cell Proliferation: Validation in a Colon Cancer Model
(previous 30 days)Site updates
Journal: Signal Transduction Insights
A Commentary on “TGF-β1-Induced Expression of the Anti-Apoptotic PAI-1 Protein Requires EGFR Signaling” (07/Sep/2009)
Plasminogen activator inhibitor-1 (PAI-1) has been found to affect a number of important cell processes and therefore abnormal expression of PAI-1 has been associated with a number of diseases and disorders. Understanding the transactivation of PAI-1 may result in identifying novel therapeutic targets.
TGF-β1 -Induced Expression of the Anti-Apoptotic PAI-1 Protein Requires EGFR Signaling (11/Jun/2009)
TGF-β1 and its target gene encoding plasminogen activator inhibitor-1 (PAI-1) are major regulators of capillary outgrowth, vessel maturation and angiogenic network stability. The increasing realization of the complexity of PAI-1 action in the vascular system requires analysis of specific signaling events that impact its expression in a physiologically-relevant cell system. PAI-1 was required for tubular differentiation and maintenance of cellular survival in complex gels since targeted disruption of PAI-1 synthesis or activity with antisense constructs...
The MAPK Signaling Cascade is a Central Hub in the Regulation of Cell Cycle, Apoptosis and Cytoskeleton Remodeling by Tripeptidyl-Peptidase II (24/Nov/2008)
Ramakrishna Sompallae1, Vaia Stavropoulou1,2, Mathieu Houde1,3 and Maria G. Masucci1 1Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden. 2Current address Department of Research, Childhood leukemia Group, University Hospital Basel, Basel, Switzerland. 3Current address Institute for Research in Immunology and Cancer (IRIC), Université de Montréal, Montréal, Canada. ...
Malignant Myeloma in a Patient After Treatment for Osteoporosis with Teriparatide; a Rare Coincidence (29/Aug/2008)
Terje Forslund1, Anna-Mari Koski2, Arvo Koistinen1 and Anu Sikiö3 1Division of Nephrology and 2Division of Endocrinology and 3Division of Haematology, Department of Medicine, Central Finland Health Care District Hospital, Jyväskylä, Finland. Abstract A breakthrough in understanding of mechanisms of bone structure regulation has brought about the introduction...
Vesa M. Olkkonen National Public Health Institute and FIMM, Institute for Molecular Medicine Finland, Biomedicum, Helsinki, Finland. Abstract Oxysterols are naturally occurring oxidized derivatives of cholesterol, or by-products of cholesterol biosynthesis, with multiple biologic functions. These compounds display cytotoxic, pro-apoptotic, and pro-inflammatory activities and may play a...
Multi-Target Approaches in Colon Cancer Chemoprevention Based on Systems Biology of Tumor Cell-Signaling (02/May/2008)
Suresh Guruswamy and Chinthalapally V. Rao Department of Medicine, Hematology-Oncology Section, University of Oklahoma Health Sciences Center, Oklahoma City, OK, U.S.A. Abstract Colorectal cancer is the leading cause of cancer related deaths in the United States. Although it is preventable, thousands of lives are lost each year...
Aggressive carcinomas ferment glucose to lactate even in the presence of oxygen. This particular metabolism, termed aerobic glycolysis, the glycolytic phenotype, or the Warburg effect, was discovered by Nobel laureate Otto Warburg in the 1920s. Since these times, controversial discussions about the relevance of the fermentation of glucose by tumours...
Transcription Initiation by Mix and Match Elements: Flexibility for Polymerase Binding to Bacterial Promoters (17/Dec/2007)
India G. Hook-Barnard and Deborah M. Hinton Gene Expression and Regulation Section, Laboratory of Molecular and Cellular Biology, National Institute of Diabetes Digestive and Kidney Diseases, National Institutes of Health, Bldg. 8 Room 2A-13, Bethesda, MD 20892-0830. Abstract Bacterial RNA polymerase is composed of...
An EGFR and AKT Signaling Pathway was Identified with Mediation Model in Osteosarcomas Clinical Study (11/Dec/2007)
Huiyun Wu1, Nicole E. Muscato2, Adriana Gonzalez2 and Yu Shyr1 1Department of Biostatistics, 2Department of Pathology, Vanderbilt University Medical Center, Nashville, TN 37232-6848, U.S.A. Abstract: Identification of correlation pattern and signal pathway among biomarkers in patients has become increasingly interesting for its potential values...
Early Onset of Heat-Shock Response in Mouse Embryos Revealed by Quantification of Stress-Inducible hsp70i RNA (06/Dec/2007)
Cristina Hartshorn, Aleksandra Anshelevich1, Yanwei Jia and Lawrence J. Wangh Department of Biology, Brandeis University, Waltham MA 02454-9110, U.S.A. 1Current address: University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6055, U.S.A. Abstract: Heat shock response is fully established in mouse...
New Insights into the Genetic Regulation of Plasmodium Falciparum Obtained by Bayesian Modeling (29/Nov/2007)
Svetlana Bulashevska1, Ezekiel Adebiyi2, Benedikt Brors2 and Roland Eils2,3 1Division ‘Theoretical Bioinformatics’, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany. 2Department of Computer and Information Sciences, Covenant University, PMB 1023, Ota, Nigeria. 3Department ‘Bioinformatics and Functional Genomics’, Institute of Pharmacy and...
Variability of DNA Microarray Gene Expression Profiles in Cultured Rat Primary Hepatocytes (18/Nov/2007)
Jun Xu1, Xutao Deng1,2, Victor Chan3, Nancy Kelley-Loughnane4, Brent W Harker5, Leming Shi6, Saber M. Hussain7, John M. Frazier7 and Charles Wang1,2 1Department of Medicine and Burns and Allen Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048; 2David Geffen School of Medicine at UCLA, Los Angeles, CA 90048; 3Alion...
Joyce Wu, Anna L. Stratford, Arezoo Astanehe and Sandra E. Dunn Laboratory for Oncogenomic Research, Departments of Pediatrics, Experimental Medicine and Medical Genetics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada.Abstract: The Y-box Binding Protein-1 (YB-1) is a highly conserved oncogenic transcription/translation factor that is...
Fernanda Ledda and Gustavo ParatchaLaboratory of Molecular and Cellular Neuroscience, Department of Neuroscience, Karolinska Institute, Retzius väg 8, 17177, Stockholm, Sweden.Abstract: Trophic factors control cellular physiology by activating specific receptor tyrosine kinases (RTKs). While the over activation of RTK signaling pathways is associated with cell growth and cancer, recent findings...