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peer reviewed open access journals 80




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  • Interview with Clinical Medicine Insights: Oncology editorial board member Prof. M. Wasif Saif
  • - 18/Jun/2010
  • Interview with Biomarkers in Cancer editorial board member Dr Xiaofeng Zhou
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  • Interview with Cell & Tissue Transplantation & Therapy editorial board member Dr Terje Forslund
  • - 17/Jun/2010
  • Interview with Nutrition and Metabolic Insights editorial board member Prof.Abdulaziz I.AL-Othaimeen
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  • Interview with Cancer Informatics editorial board member Dr Philip Crooke
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  • Interview with Translational Oncongenomics Editor in Chief Dr Michael Spinella
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Fentanyl Buccal Tablet for the Treatment of Breakthrough Pain: Pharmacokinetics of Buccal Mucosa Delivery and Clinical Efficacy     (04/Jun/2010)


The treatment of breakthrough pain (BTP), a transitory exacerbation of pain that occurs on a background of otherwise-controlled, persistent pain, requires an opioid formulation and/or method of administration that can provide rapid and extensive systemic exposure. Fentanyl buccal tablet (FBT; FENTORA®, Cephalon, Inc.) employs OraVescent® drug delivery technology, which enhances...


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Current and Emerging Pharmacotherapies of Breakthrough Pain in Cancer     (19/Apr/2010)


Breakthrough pain (BTP), defined as “transitory episodes of sudden severe pain that occur on a background of otherwise controlled pain” is common and disturbing for cancer patients. Optimal management of sudden, severe, and transitory episodes of BTP requires analgesics with rapid onset and short duration of effect, ideally in convenient...


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Duloxetine: Its Role in the Management of Chronic Pain     (24/Feb/2010)


Chronic pain represents one of the most important public health problems and, in addition to classical analgesics, antidepressants are an essential part of therapeutic management. This is due to the regulation of pain signals in the central nervous system and the spinal cord by serotonin and noradrenaline. As the role...


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Methadone Cardiotoxicity in Pain Management—An Important Issue for Clinicians     (03/Feb/2010)


Morphine or other strong opioids (fentanyl, oxycodone, hydromorphone, buprenorphine) are usually administered in patients with severe cancer and chronic non-malignant pain. However, when these analgesics are ineffective in terms of analgesia or induce intractable adverse effects, a switch to methadone might prove beneficial. Consequently methadone is used in opioid rotation...


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Pharmacotherapy of Fibromyalgia: Focus on Duloxetine     (17/Nov/2009)


Context: Fibromyalgia syndrome (FMS) is a frequent medical condition characterized by chronic widespread pain and reduced pain threshold. Associated symptoms include fatigue, non restorative sleep, and psychological distress. As usual in medicine, even if the pathogenesis is unclear, some treatments are useful to help patients. Objectives: Tricyclic antidepressants were the first...


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Pregabalin and Fibromyalgia Syndrome: A Treatment Option     (15/Jul/2009)


Fibromyalgia (FM) is a chronic complex pain disorder that is multidimensional and exhibits heterogeneity requiring a long-term multidisciplinary approach to management. Many of the drugs used in the treatment of FM have been focused to the management of single symptoms; often such drugs fail to demonstrate acceptable efficacy in the...


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Pharmacotherapy Update: Hyoscine Butylbromide in the Treatment of Abdominal Spasms     (23/Jun/2009)


Abdominal pain is one of the most common reasons why people seek medical care, and is often due to spasm of intra-abdominal visceral organs. Hyoscine butylbromide (HBB) is a quaternary ammonium compound which blocks the action of acetylcholine at parasympathetic sites (both muscarinic and nicotinic receptors) in smooth muscle, and...