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peer reviewed open access journals 80




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Micelle Enhanced Fluorimetric and Thin Layer Chromatography Densitometric Methods for the Determination of (±) Citalopram and its S – Enantiomer Escitalopram     (07/Apr/2009)


Two sensitive and validated methods were developed for determination of a racemic mixture citalopram and its enantiomer S-(+) escitalopram. The first method was based on direct measurement of the intrinsic fluorescence of escitalopram using sodium dodecyl sulfate as micelle enhancer. This was further applied to determine escitalopram in spiked human...


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Sophisticated Functions for a Simple Molecule: The Role of Glucosylceramides in Fungal Cells     (10/Sep/2008)


Leonardo Nimrichter1, Marcio L. Rodrigues1, Eliana Barreto-Bergter1 and Luiz R. Travassos2 1Instituto de Microbiologia Professor Paulo de Góes, Universidade Federal do Rio de Janeiro, 21941-590, Brazil. 2Unidade de Oncologia Experimental and Disciplina de Biologia Celular, Universidade Federal de São Paulo; São Paulo, SP 04023-062, Brazil. Abstract It...


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Development and Validation of a HPLC Method to Determine Griseofulvin in Rat Plasma: Application to Pharmacokinetic Studies     (27/Aug/2008)


A simple, specific, sensitive, and rapid high performance liquid chromatography (HPLC) method for the determination of griseofulvin in small volumes of rat plasma was developed and validated using warfarin as an internal standard. Biological sample preparation involved simple extraction with acetonitrile, followed by dilution with aqueous mobile phase buffer (20...


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Enantioselective Gas Chromatographic Separation of Racemic N-alkylated Barbiturates: Application of C11-Chirasil-Dex as Chiral Stationary Phase in GC     (18/Sep/2007)


Ashraf Ghanem Biomedicinal Chemistry Unit, Biological and Medical Research Department, King Faisal Specialist Hospital and Research Centre, (MBC-03-95), P.O. Box 3354, Riyadh 11211, Saudi Arabia.Dedication: Dedicated to Professor Volker Schurig on the Occasion of his birthday.Abstract: Chirasil-β-Dex containing an undecamethylene spacer (C11-Chirasil-Dex) was synthesized and used as chiral stationary phase...


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The Influence of Free 3-Nitrotyrosine and Saliva on the Quantitative Analysis of Protein-Bound 3-Nitrotyrosine in Sputum     (14/Feb/2007)


Kazuhito Ueshima, Yoshiaki Minakata, Hisatoshi Sugiura, Satoru Yanagisawa, Tomohiro Ichikawa, Keiichirou Akamatsu, Tsunahiko Hirano, Masanori Nakanishi, Kazuto Matsunaga, Toshiyuki Yamagata and Masakazu Ichinose Third Department of Internal Medicine, Wakayama Medical University, Wakayama, Japan.Abstract:Background: We have recently developed a new technique for quantitatively measuring protein-bound 3-nitrotyrosine (3-NT), a footprint of nitrosative...