Home| About us| My LA: login/register| For authors| For reviewers| Submit a paper
(close)

(Ctrl-click to select multiple journals)


How should we address you?

Your email address


 Yes, sign up now
 Sign up for general news too

Privacy Statement
 
 
 

Analytical Chemistry Insights

Synopsis: An open access, peer reviewed electronic journal that covers developments in the field including analytical methodology, techniques and instrumentation in the fundamental and applied areas of the field.


Indexing: Six major databases. Pubmed indexing for NIH-funded research.

Processing time: Decision in 2 weeks for 90% of papers.

Visibility: Most popular article read 2000+ times.

RSS

NEWS

TWITTER
View factor
for journal
98306


About this journal

Aims and scope:

Analytical Chemistry Insights covers current developments in all areas of the field, including analytical methodology, techniques and instrumentation in the fundamental and applied areas of the field. The journal also focuses on drug analysis and analytical methodology and instrumentation, in recognition of the interrelationship between analytical chemistry and pharmaceutical analysis.

Analytical Chemistry Insights seeks to be the most timely journal for those who need to be up to date with the latest and most important developments in the field. The journal offers high-speed and credible pre-production submission processing to authors. By publishing in open-access format, authors are able to communicate with the widest possible group of readers.

Editorial standards and procedures:

Submissions, excluding editorials, letters to the editor and dedications, will be peer reviewed by two reviewers.  Reviewers are required to provide fair, balanced and constructive reports.  

Under our Fairness in Peer Review Policy authors may appeal against reviewers' recommendations which are ill-founded, unobjective or unfair.  Appeals are considered by the Editor in Chief or Associate Editor.

Papers are not sent to peer reviewers following submission of a revised manuscript. Editorial decisions on re-submitted papers are based on the author's response to the initial peer review report.

Indexing:

This journal is indexed by the following services:

  • SCOPUS
  • Google Scholar
  • CAS
  • DOAJ
  • Intute
  • EBSCO Academic Search Complete

SPARC Europe Seal award winner:

This journal has been awarded a SPARC Europe Seal. The Seal is an initiative of SPARC Europe (Scholarly Publishing and Academic Resources Coalition) and the Directory of Open Access Journals (DOAJ) which is awarded to journals applying a Creative Commons CC-BY copyright license and that make journal metadata accessible to DOAJ.  

 Amongst other important services DOAJ makes metadata OAI-compliant.  This in turn enhances the visibility of papers and allows OAI-harvesters to include the details of journal articles in their services. We encourage readers to make use of this valuable resource.  The DOAJ search page is available here.

National Institutes of Health Public Access Policy compliant:

As of April 7 2008, the US NIH Public Access Policy requires that all peer reviewed articles resulting from research carried out with NIH funding be deposited in the Pubmed Central archive.

If you are an NIH employee or grantee Libertas Academica will ensure that you comply with the policy by depositing your paper at Pubmed Central on your behalf. 

ISSN: 1177-3901


Bookmark journal

FACEBOOK
YAHOO! BUZZ
DIGG
LINKEDIN
Add to Mixx! MIXX
PERMALINK


 
 
 


Development and Validation of a HPLC Method to Determine Griseofulvin in Rat Plasma: Application to Pharmacokinetic Studies

Authors: Bo Wei, Dong Liang, and Theodore R. Bates
Publication Date: 27 Aug 2008
Analytical Chemistry Insights 2008:3 103-109

Bo Wei, Dong Liang and Theodore R. Bates

Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Texas Southern University, 3100 Cleburne Street, Houston, TX 77004.

Abstract

A simple, specific, sensitive, and rapid high performance liquid chromatography (HPLC) method for the determination of griseofulvin in small volumes of rat plasma was developed and validated using warfarin as an internal standard. Biological sample preparation involved simple extraction with acetonitrile, followed by dilution with aqueous mobile phase buffer (20 mM sodium dihydrogen phosphate, pH 3.5) to eliminate any chromatographic solvent effects. Griseofulvin and warfarin were baseline separated and quantitated on a C18 reversed phase column (4.6 ×  150 mm, 3.5 µ m), using a mobile phase composed of a 20 mM aqueous solution of sodium dihydrogen phosphate-acetonitrile (55:45, v/v, pH 3.5) delivered at a flow rate of 1.0 mL/min, and with fluorescence detection (λexcitation = 300 nm, λemission = 418 nm). The method was proven to be linear over a plasma griseofulvin concentration range of 10 to 2500 ng/mL with a mean correlation coefficient of 0.9996. The intra-day and inter-day accuracy (relative error) were in the range of 0.89% to 9.26% and 0.71% to 7.68%, respectively. The within-day precision (coefficient of variation) was less than 3.0% and the between-day precision was less than 7.5%. The mean recovery of griseofulvin from rat plasma was found to be 99.2%. The limit of detection (LOD) and the limit of quantification (LOQ) of griseofulvin were determined to be 1 ng/mL and 10 ng/mL, respectively. The developed method was successfully applied to quantitatively assess the pharmacokinetics of griseofulvin in rats following a single 50 mg/kg oral dose of the drug.



Post comment




Posted by
ChemSpiderMan
13:45,August 29, 2008

The structure of Griseofulvin as drawn is an incorrect representation. The correct representation is as shown here on ChemSPider. http://www.chemspider.com/Chemical-Structure.389934.html The author can download the structure and use this one if he wishes...have him contact me if he has problems. The issue is with stereocenters.


Bookmark this article

LINKEDIN FACEBOOK

Add to Mixx! MIXX YAHOO! BUZZ

PERMALINK DIGG


Sign up for free journal updates

How should we address you?
Your email address
 Yes, sign up now


Recently published in this journal

Micelle Enhanced Fluorimetric and Thin Layer Chromatography Densitometric Methods for the Determination of (±) Citalopram and its S – Enantiomer Escitalopram
- 07/Apr/2009

New Spectrofluorimetric Method with Enhanced Sensitivity for Determination of Paroxetine in Dosage Forms and Plasma
- 18/Nov/2008

Use of Fourier Transform Infrared (FTIR) Spectroscopy to Study Cadmium-Induced Changes in Padina Tetrastromatica (Hauck)
- 15/Oct/2008

Palm-Based Standard Reference Materials for Iodine Value and Slip Melting Point
- 22/Sep/2008

Comparison of Gas Chromatography-Mass Spectrometry and Gas Chromatography-Tandem Mass Spectrometry with Electron Ionization and Negative-Ion Chemical Ionization for Analyses of Pesticides at Trace Levels in Atmospheric Samples
- 09/Sep/2008

Microalbuminuria Measured by three Different Methods, Blood Pressure and Cardiovascular Risk Factors in Elderly Swedish Males
- 02/Sep/2008

A Simple and Selective Spectrophotometric Method for the Determination of Trace Gold in Real, Environmental, Biological, Geological and Soil Samples Using Bis (Salicylaldehyde) Orthophenylenediamine
- 29/Aug/2008

Development and Validation of a HPLC Method to Determine Griseofulvin in Rat Plasma: Application to Pharmacokinetic Studies
- 27/Aug/2008

Micellar Electrokinetic Chromatographic Study of the Separation of an Aromatase Inhibitor and a Tryciclic Antidepressant in the Breast Cancer Treatment
- 13/Aug/2008

Uncertainty Analysis of Drug Concentration in Pharmaceutical Mixtures
- 03/Jun/2008

High-Performance Liquid Chromatographic Method for Determination of Phenytoin in Rabbits Receiving Sildenafil
- 18/Apr/2008

Understanding Structural Features of Microbial Lipases—An Overview
- 27/Mar/2008

Determination of Key Intermediates in Cholesterol and Bile Acid Biosynthesis by Stable Isotope Dilution Mass Spectrometry
- 25/Mar/2008

Optimized and Validated Spectrophotometric Methods for the Determination of Enalapril Maleate in Commercial Dosage Forms
- 01/Mar/2008

Detecting the Site of Phosphorylation in Phosphopeptides Without Loss of Phosphate Group Using MALDI TOF Mass Spectrometry
- 26/Feb/2008

Solid-Phase Extraction and Reverse-Phase HPLC: Application to Study the Urinary Excretion Pattern of Benzophenone-3 and its Metabolite 2,4-Dihydroxybenzophenone in Human Urine
- 31/Jan/2008

Role of 99mTc-(V)DMSA in Detecting Tumor Cell Proliferation
- 13/Dec/2007

Solid Phase Extraction for Monitoring of Occupational Exposure to Cr (III)
- 11/Dec/2007

Hazard Identification on a Single Cell Level Using a Laser Beam
- 06/Dec/2007

Identification of Cysteine Proteases and Screening of Cysteine Protease Inhibitors in Biological Samples by a Two-Dimensional Gel System of Zymography and Reverse Zymography
- 18/Nov/2007

A Practical Approach to Red Blood Cell Folate Analysis
- 14/Nov/2007

NS-187 (INNO-406), a Bcr-Abl/Lyn Dual Tyrosine Kinase Inhibitor
- 14/Nov/2007

UV-Vis Spectrophotometrical and Analytical Methodology for the Determination of Singlet Oxygen in New Antibacterials Drugs
- 11/Nov/2007

Possible Impact of Salivary Influence on Cytokine Analysis in Exhaled Breath Condensate
- 12/Oct/2007

Enantioselective Gas Chromatographic Separation of Racemic N-alkylated Barbiturates: Application of C11-Chirasil-Dex as Chiral Stationary Phase in GC
- 18/Sep/2007

Vibratory Reaction Unit for the Rapid Analysis of Proteins and Glycochains
- 17/Sep/2007

Determination of the Labile Iron Pool of Human Lymphocytes using the Fluorescent Probe, CP655
- 17/Sep/2007

Unexpected Different Binding of Mistletoe Lectins from Plant Extracts to Immobilized Lactose and N-acetylgalactosamine
- 17/Sep/2007

Biomedical and Forensic Applications of Combined Catalytic Hydrogenation-Stable Isotope Ratio Analysis
- 06/Sep/2007

Identification and Quantitation of Asparagine and Citrulline Using High-Performance Liquid Chromatography (HPLC)
- 28/Mar/2007

Canine Plasminogen: Spectral Responses to Changes in 6-Aminohexanoate and Temperature
- 22/Mar/2007

The Use of Ion Chromatography for the Determination of Clean-In-Place-200 (CIP-200) Detergent Traces
- 27/Feb/2007

The Influence of Free 3-Nitrotyrosine and Saliva on the Quantitative Analysis of Protein-Bound 3-Nitrotyrosine in Sputum
- 14/Feb/2007

Novel Plasmid Transformation Method Mediated by Chrysotile, Sliding Friction, and Elastic Body Exposure
- 14/Feb/2007

Direct Enantiomeric Resolution of Betaxolol with Application to Analysis of Pharmaceutical Products
- 06/Feb/2007



Related journals...