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Journal: Biomedical Engineering and Computational Biology
Editor in Chief: Kayvan Najarian | Table of contents | 6630 views
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Heat shock proteins (HSP) are essential for intracellular protein folding during stress and protect cells from denaturation and aggregation cascades that can lead to cell death. HSP genes are regulated at the transcriptional level by heat shock transcription factor 1 (HSF1) that is activated by stress and binds to heat...
Network Robustness Due to Multiple Positive Feedback Loops: A Systematic Study of a Th Cell Differentiation Model (16/Apr/2010)
Positive feedback loops have been identified in many biological signal transduction systems. Their importance in a system’s bistability has been well established by identifying multiple steady states of a network under different parameters. In this paper, we identify the contribution of positive feedback loops to network robustness by a systematic...
No abstract provided.
Signal Transduction Involving the Dmp1 Transcription Factor and its Alteration in Human Cancer (01/Apr/2008)
Takayuki Sugiyama1,2, Donna P. Frazier1,2, Pankaj Taneja1,2, Robert D. Kendig1,2, Rachel L. Morgan1,2, Lauren A. Matise1,2, Sarah J. Lagedrost1,2 and Kazushi Inoue1,2 1The Departments of Pathology, 2Cancer Biology, Wake Forest University Health Sciences, Medical Center Boulevard, Winston-Salem, N.C. 27157-0001, U.S.A. Abstract Dmp1 (cyclin D-interacting myb-like protein...
Introductory Editorial (Signal Transduction Insights) (25/Mar/2008)
Edgar Grinstein Heinrich Heine University Medical Center, Düsseldorf, Germany.