Pulmonary medicine
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Journal: Clinical Medicine Insights: Case Reports
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Pulmonary Tuberculosis: Focus on the Fluoroquinolones (13/Apr/2010)
Fluoroquinolone antibiotics are relatively new drugs in anti-tuberculosis (TB) treatment, with the potential to become the first new class of drugs to be recommended for routine treatment since rifamycins in the 1960s. Later generation fluoroquinolones, including levofloxacin, gatifloxacin, and moxifloxacin have been found to be safe and well-tolerated in observational...
Management of Chronic Obstructive Pulmonary Disease with Tiotropium Bromide (30/Mar/2010)
In COPD, pathologic upregulation and stimulation of muscarinic (M) receptors contribute to bronchospasm, mucus hypersecretion and possibly airway remodeling. Tiotropium bromide (brand name Spiriva; Boehringer Ingelheim/Pfizer) inhalational powder was approved by the US Food and Drug Administration in January 2004 for the long-term, once-daily, maintenance treatment of bronchospasm associated with...
Pulmonary arterial hypertension (PAH) is a progressive disease leading to obstruction of the small pulmonary arteries. Currently, there are eight approved medications for PAH. This review article focuses on the mechanisms, clinical trials, efficacy, and safety profiles of each of the PAH medications. In addition, this review addresses combination PAH...
Safety and Efficacy of Ambrisentan in the Treatment of Pulmonary Arterial Hypertension (27/May/2009)
Christopher J Valerio1, Peter Kabunga2 and John G Coghlan11Department of Cardiology, Royal Free Hospital, London, UK. 2Department of Medicine, Borders General Hospital, Melrose, Borders, Scotland, UK.AbstractThree different classes of specific therapy exist for pulmonary arterial hypertension. Ambrisentan belongs to the endothelin receptor antagonist (ERA) class of drugs, which inhibit the...
Pharmacotherapy of Systemic Sclerosis: focus on Bosentan (16/Apr/2009)
Kamyar Afshar and Ayana Boyd-KingUniversity of Southern California, Keck School of Medicine, Division of Pulmonary and Critical Care Medicine, Los Angeles, CA, USA.AbstractSystemic sclerosis is manifested by the massive deposition of collagen within various organ systems. Endothelin-1 has taken a pivotal role as not only a potent vasoconstrictor, but also...
Sitaxentan for the Oral Treatment of Pulmonary Arterial Hypertension: Benefits from Endothelin Receptor Subtype Selectivity? (16/Apr/2009)
Hermann A.M. MuckeH.M. Pharma Consultancy, Wien (Vienna), Austria.AbstractPulmonary arterial hypertension (PAH) is a deadly and underdiagnosed disease which causes right heart failure secondary to pressure overload resulting from the thickening of the pulmonary artery endothelium, associated with elevated levels of circulating endothelin-1. Sitaxentan was the first endothelin antagonist with high...
Management of Pleural Brucellosis: Case Report (03/Apr/2009)
Background: Brucellosis is a zoonotic disease, with low incidence rate in developed countries, however the incidence rate in Middle Eastern countries remains high. Chest symptoms in brucellosis cases account for about 15% of the cases, but dealing with respiratory system involvement is rare particularly pleural involvement. Case Report: We report a...
Exercise-Echocardiography–Derived Pulmonary Artery Pressure Slope in Borderline and Mild to Moderate Pulmonary Arterial Hypertension Naser M. Ammash1, Michael D. McGoon1, Clarence Shub1, James B. Seward1, Jae K. Oh1, Michael J. Krowka2, Patricia A. Pellikka1, Brenda S. Moon1, Kent R. Bailey3, Christina M. Wood3 and A. Jamil Tajik1...
Pulmonary Biomarkers of Bronchopulmonary Dysplasia (02/Jul/2008)
Alecia Thompson and Vineet Bhandari Department of Pediatrics, Division of Perinatal Medicine, Yale University School of Medicine, New Haven, CT 06520. Abstract Bronchopulmonary dysplasia, or BPD, is a chronic pulmonary disorder of premature infants, commonly defined as having an oxygen requirement at 36 weeks postmenstrual age. It...
Tasbirul Islam1, George Hines2, Douglas S. Katz3, William Purtil4 and Francis Castiller5 1Fellow, Pulmonary and Critical Care Medicine, Winthrop-University Hospital, Mineola, NY, USA. 2Director, Department of Vascular Surgery, Winthrop-University Hospital, Mineola, NY, USA. Professor of Clinical Surgery, State University of New York at Stony Brook, Stony Brook, NY,...
Characterization of Hemodynamics in Patients with Idiopathic and Thromboembolic Pulmonary Hypertension (21/May/2008)
Carmelle V. Remillard and Jason X.-J. Yuan Division of Pulmonary and Critical Care Medicine, Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, CA 92093-0725. Abstract Demographic and hemodynamic data from patients with idiopathic pulmonary arterial hypertension (IPAH) and chronic thromboembolic pulmonary hypertension...
Surgical Removal of a Knotted Intravascular Pulmonary Artery Catheter (20/May/2008)
Kotaro Kaneda, Tae-Hyung Han Department of Anesthesia, The University of Iowa Hospitals and Clinics, Roy J. and Lucille A. Carver College of Medicine, Iowa City, Iowa. U.S.A. Abstract A pulmonary artery (PA) catheter was placed in a 60-year-old patient with congestive heart failure, undergoing lumbar spinal surgery. In...