Dermatology

Clobetasol-17 propionate is a dihalogenated corticosteroid which, on the basis of the vasoconstrictor assay, is classified as the most potent of all topical steroids. Since 1973 it has been marketed specifically for the short term topical treatment of moderate and severe cortico-responsive dermatoses for its antinflammatory, immunosuppressive and antimitotic effects....

Objective: Presentation of chondrodermatitis nodularis helicis chronica that is an uncommon but important differential diagnosis for particular benign and malignant tumours. Case report: A 32-year-old woman presented with a painful, hyperkeratotic nodule on her left antihelix. The lesion was treated with cryotherapy and resolved completely. Conclusion: Chondrodermatitis nodularis helicis should be considered...

Oritavancin is a semisynthetic lipoglycopeptide with in vitro activity against a variety of aerobic Gram-positive pathogens (including drug-resistant forms of staphylococci, streptococci, and enterococci) and select anaerobic organisms. Available published clinical efficacy and safety studies in humans to date focus primarily in the treatment of complicated skin and skin structure...

Introductory Editorial by Dr Karna Dev Bardhan

Nicolau Syndrome, first described in the 1920’s in patients treated with bismuth salts for syphilis, is a rare adverse reaction at the site of intramuscular drug injection. It is clinically characterized by severe pain immediately after injection, and rapid development of blanched skin or livedoid reticular patches. Occlusion of peripheral...

Psoriasis is a chronic inflammatory cell-mediated disease affecting skin and joints, histologically characterized by epidermal hyperplasia and abnormal differentiation of keratinocytes. Plaque psoriasis, which is the most prevalent form of the disease, is clinically characterized by raised, inflamed, erythematous lesions covered by white silvery scales, located on the elbows, knees,...

Imiquimod (trade name Aldara™) is a small molecule of the imidazoquinoline family, a group of nucleoside analogs that were first synthesized as potential antiviral agents. It has since been discovered to activate both innate and adaptive immunity, as well as apoptosis. Clinically, it has been approved for three indications thus...

Crossplasty is a modified O-T advancement flap. It is an alternative technique to close double surgical defects, which are arranged in a vertical line. It is useful to camouflage the scar in forehead parallel lines. Geometrically, it is an inverted T joined to a vertical linear defect. There are three...

Tigecycline is the first of a new class of antibiotics named glycylcyclines and is active in vitro against a variety of gram-positive and gram-negative organisms, including nosocomial resistant pathogens such as vancomycin-resistant Enterococcus faecium, methicillin-resistant Staphylococcus aureus, extended-spectrum β-lactamase-producing Enterobacteriaceae, and multidrug-resistant-Acinetobacter spp. This medication has been approved by the...

Objective: Presentation of pyoderma gangraenosum (PG) as an important differential diagnosis for wound healing disorders after cesarian section. Adequate therapeutic regimens are discussed. Case report: A 39-year-old woman developed a PG after cesarean section. A treatment with prednisolone and cyclosporine A was started. Within three days of treatment, the inflammatory process...

Rhytides, wrinkles and other signs of photoaging are gaining in prevalence due to increased sun exposure, phototoxic drugs and demographic changes. Cosmeceutical products, lasers, and surgery have all been used to reverse the signs of aging. However, these treatment modalities have suffered from either limited efficacy or a high incidence...

Due to years of sophisticated research on T cell function, many dermatologists have viewed atopic dermatitis (AD) largely as an inflammatory disorder of TH1/TH2 imbalance. Hence, therapy has largely consisted of topical immunomodulators and/or steroids. The imposition of “black box” warnings about the potential toxicity associated with prolonged use of...

Miranda A. Farage1, Philip Bowtell2 and Alexandra Katsarou3 1Feminine Clinical Sciences, The Procter and Gamble Company, Cincinnati OH. 2Development Statistics Group, The Procter and Gamble Company, Egham, U.K. 3Dermatology, University of Athens Medical School, Athens, Greece. Abstract Background:  Sensitive skin is largely self-diagnosed and linked to reactions...

Thomas C. Tsai, BS and Basil M. Hantash Program for Regenerative Medicine, Stanford University School of Medicine, Stanford, CA. Abstract Cosmeceuticals represent one of the most promising, yet challenging treatment options available to physicians. They are the fastest growth segment in the skin-care market, and a number...

Rene Thonhofer, Markus Trummer, Cornelia Siegel and Elisabeth Uitz Department of Internal Medicine, State Hospital Muerzzuschlag, Austria. Abstract Introduction: Leukocytoclastic vasculitis (LV) is a necrotising vasculitis of the small dermal blood vessels, clinically presented as palpable purpura. It is a heterogeneous disorder often limited to the skin...

Susan Faber West1 and Peter E. Pidcoe2 1Department of Physical Therapy Outpatient Team, Medical College of Virginia Hospitals, Richmond, Virginia, U.S.A. 2Department of Physical Therapy, Virginia Commonwealth University—Medical College of Virginia, Richmond, VA 23298. Abstract Background:  This report illustrates the use of pressure for scar management to...

Julia Grabowski1, Sidney L Saltzstein1,2,3,4, Georgia Robins Sadler3,4, Zunera Tahir4 and Sarah Blair3,4 1Department of Family and Preventive Medicine, University of California at San Diego School of Medicine, La Jolla, CA. 2Department of Pathology, University of California at San Diego School of Medicine, La Jolla, CA. 3Department of Surgery,...

Florentina Silvia Delli1, Thomas Zaraboukas2 and Ioanna Mandekou-Lefaki3 1Dermatology Department, Private Practice, Thessaloniki, Greece. 2Anatomopathology Department, Aristotle University of Thessaloniki, Greece. 3Dermatology Department, State Hospital for Skin and Venereal Diseases, Thessaloniki, Greece. Abstract Primary cutaneous lymphomas are the second most common site of extranodal non-Hodgkin lymphoma. A specifically...

Lester J. Layfield1, Lyska Emerson1, Julia R. Crim2 and Lor Randall3 1Departments of Pathology. 2Radiology and 3Orthopedic Surgery (Sarcoma Service) University of Utah Hospital and Clinics, Salt Lake City, Utah, 84132. Abstract Cytokeratin expression has been documented in a variety of sarcomas including synovial sarcomas, epithelioid sarcomas,...

Emanuela Corsini, Omar Zancanella, Laura Lucchi, Barbara Viviani, Marina Marinovich and Corrado L. Galli Laboratory of Toxicology, Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy.Abstract: Skin irritation is a complex phenomenon, and keratinocytes play an important role in it. We have recently characterized the expression...