Geriatrics

Objectives: To find out whether and to what extent the muscle functions are impaired in polymyalgia rheumatica (PMR) patients in relation to duration, activity and treatment of the disease as well as any history of giant cell-arteritis (GCA). Methods: Comprehensive clinical examinations of PMR patients (N = 40) called to participate...

Heart failure (HF) is a very prevalent disease in the United States and in Europe, with the highest prevalence among older patients. Population estimates suggest substantial growth among the elderly over the next four decades. However, older patients are underrepresented in clinical trials evaluating HF therapies and are less likely...

Lamotrigine is an oral well absorbed antiepileptic medication (AED) from the phenyltriazine class approved by the FDA in 1994 for the treatment of epilepsy and in 2003 for the treatment of bipolar disorder. For epilepsy it is used to treat partial seizures, primary and secondary tonic–clonic seizures, and seizures associated...

Dementia is a syndrome characterized by a decline in cognitive function. Alzheimer’s disease and cerebro-vascular disease are the most common causes of dementia. Many factors (genetic, life style, vascular etc.) appear to play some role in the development of dementia. Statins significantly reduce vascular disease and could reduce cognitive impairment...

The term ‘frailty’ has often been used—by clinicians and researchers alike—to characterize the most vulnerable and weak amongst the elderly. The treatment and care of this subgroup of older individuals presents the most challenge to clinicians and other health care professionals. Although there is no clear consensus on the issue...

Ryotaro Wake1, Hidetaka Iida2, Shinichi Shimodozono2, Yukio Yamada2, Takanori Kusuyama2, Hiroaki Takeshita2 and Minoru Yoshiyama11Department of Internal Medicine and Cardiology, Osaka City University Graduate School of Medicine, Osaka, Japan. 2Department of Cardiology, Tsukazaki Hospital, Hyogo, Japan. AbstractAn epidemic increase in heart failure (HF) mortality, hospitalization, and prevalence rates has been...

Gabriel Sandblom1, Tommy Bergman2 and Ib Rasmussen31Department of Surgery, University Hospital of Lund, Lund, Sweden. 2Department of Surgery, Södertälje Hospital, Södertälje, Sweden. 3Department of Surgery, University Hospital of Uppsala, Uppsala, Sweden.Abstract Objective: To explore the incidence and severity of pancreatitis and to assess the outcome of all measures taken...

Andrew W. Gardner1,2 and Polly S. Montgomery1,2 1CMRI Metabolic Research Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK. 2Department of Medicine, Division of Gerontology, University of Maryland, Baltimore, MD. Abstract Purposes:  (a) To compare exercise performance and leisure-time physical activity (LTPA) between older Caucasians and...

Malakh Shrestha, Nawid Khaladj, Hassina Baraki, Axel Haverich and Christian Hagl Division of Cardiac, Thoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany. Abstract Introduction: This study was undertaken to analyze the risk of peri-operative mortality and morbidity after Cardiac Surgery with Cardio-pulmonary Bypass (CPB) in...

Anouk Déruaz1, Avinoam B. Safran2, Markus Sutter3 and René M. Müri1 1Perception and Eye Movement Laboratory, Department of Neurology and Department of Clinical Research, University of Bern, Inselspital, CH-3010 Bern, Switzerland. 2Ophthalmogy Clinic, Department of Clinical Neurosciences and Dermatology, Geneva University Hospitals, CH-1211 Geneva 4,...

Anne L. Coleman1, Gergana Kodjebacheva1,2, Steven P. Wallace2, Michael Prelip2, Alexander N. Ortega3, Joann Giaconi1, Fei Yu1,4 and Abdelmonem A. Afifi4 1Jules Stein Eye Institute, Department of Ophthalmology, David Geffen School of Medicine, University of California, Los Angeles. 2School of Public Health, Department of Community Health Sciences, University of...

Frank J. Molnar1,2,3,4,6, George A. Wells5 and Ian McDowell5 1The CT Lamont Centre, Élisabeth-Bruyère Research Institute, Ottawa. 2The Division of Geriatric Medicine, Department of Internal Medicine, University of Ottawa. 3The Clinical Epidemiology Program, the University of Ottawa Health Research Institute, Ottawa. 4DementiaNET—a CIHR New Emerging Team. 5The Department of...

Introductory Editorial by Dr David Simar, School of Medical Sciences, University of New South Wales, Sydney NSW 2052, Australia.

Li Lin Key laboratory of cellular physiology, Shanxi Medical University, China. Abstract A surprising common pathological processes is found between Alzheimer’s disease (AD) and type 2 diabetes mellitus (T2DM)[1]. AD and T2DM share some common pathological processes: Amyloid β (Aβ), τ hyperphosphoralation, insulin abnormality. Disturbance in insulin signalling is...

Noboru Saito1,2, Akiyoshi Seshimo1 and Shingo Kameoka1 1Departments of Surgery II and 2General Medicine, Tokyo Women’s Medical University School of Medicine, Tokyo, Japan. Abstract Purpose:  Improve risk management of patients undergoing investigations of the gastrointestinal (GI) tract, in regard to underlying diseases and choice of premedication. According...

Andrew W. Gardner1,2 and Polly S. Montgomery1,2 1CMRI Metabolic Research Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK. 2Department of Medicine, Division of Gerontology, University of Maryland, Baltimore, MD. Abstract Purposes:  (a) To compare exercise performance and leisure-time physical activity (LTPA) between older men and...

Kenneth M. Madden1, Wayne C. Levy2 and John R. Stratton2 1Department of Medicine, University of British Columbia, Vancouver, BC, Canada, 2Department of Medicine, Division of Cardiology, Seattle Veterans Affairs Medical Center and the University of Washington, Seattle, Washington Abstract Background: Normalized ratios of portions of the power...