Enantioselective Gas Chromatographic Separation of Racemic N-alkylated Barbiturates: Application of C11-Chirasil-Dex as Chiral Stationary Phase in GC
Authors: Ashraf Ghanem
Publication Date: 18 Sep 2007
Analytical Chemistry Insights 2007:2 75-80
Ashraf Ghanem
Biomedicinal Chemistry Unit, Biological and Medical Research Department, King Faisal Specialist Hospital and Research Centre, (MBC-03-95), P.O. Box 3354, Riyadh 11211, Saudi Arabia.
Dedication: Dedicated to Professor Volker Schurig on the Occasion of his birthday.
Abstract: Chirasil-β-Dex containing an undecamethylene spacer (C11-Chirasil-Dex) was synthesized and used as chiral stationary phase (CSP) in enantioselective gas chromatography (GC). The versatility of the new stationary phase in the simultaneous enantiomeric separation of a set of N-alkylated barbiturates is demonstrated.
Keywords: Chirasil-β-Dex, enantiomeric excess, gas chromatography, N-alkylated barbiturates
Download this full text open access article
Send to EndnoteView on Pubmed
(607.76 KB PDF format)
Readers of this also read:
- Enantioselective Gas Chromatographic Separation of Racemic N-alkylated Barbiturates: Application of C11-Chirasil-Dex as Chiral Stationary Phase in GC
- High-Performance Liquid Chromatographic Method for Determination of Phenytoin in Rabbits Receiving Sildenafil
- Solid-Phase Extraction and Reverse-Phase HPLC: Application to Study the Urinary Excretion Pattern of Benzophenone-3 and its Metabolite 2,4-Dihydroxybenzophenone in Human Urine
- Direct Enantiomeric Resolution of Betaxolol with Application to Analysis of Pharmaceutical Products
- Optimized and Validated Spectrophotometric Methods for the Determination of Enalapril Maleate in Commercial Dosage Forms
