Translational Oncogenomics
Synopsis: An open access, peer reviewed electronic journal that covers novel genetic, epigenetic and molecular pathway information related to clinical cancer.
Indexing: 6 major databases. Pubmed indexing for NIH-funded research.
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Editor in chief:
Michael Spinella
ISSN: 1177-2727
YB-1 is a Transcription/Translation Factor that Orchestrates the Oncogenome by Hardwiring Signal Transduction to Gene Expression
Authors: Joyce Wu, Anna L. Stratford, Arezoo Astanehe and Sandra E. Dunn
Publication Date: 11 May 2007
Translational Oncogenomics 2007:2 49-65
Joyce Wu, Anna L. Stratford, Arezoo Astanehe and Sandra E. Dunn
Laboratory for Oncogenomic Research, Departments of Pediatrics, Experimental Medicine and Medical Genetics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada.
Abstract: The Y-box Binding Protein-1 (YB-1) is a highly conserved oncogenic transcription/translation factor that is expressed in cancers affecting adults and children. It is now believed that YB-1 plays a causal role in the development of cancer given recent work showing that its expression drives the tumorigenesis in the mammary gland. In human breast cancers, YB-1 is associated with rapidly proliferating tumors that are highly aggressive. Moreover, expression of YB-1 promotes the growth of breast cancer cell lines both in monolayer and anchorage independent conditions. The involvement of YB-1 in breast cancer pathogenesis has made it a putative therapeutic target; however, the mechanism(s) that regulate YB-1 are poorly understood. This review first describes the oncogenic properties of YB-1 in cancer. It also highlights the importance of YB-1 in hardwiring signal transduction pathways to the regulation of genes involved in the development of cancer.
Keywords: YB-1, cancer, phosphorylation, signal transduction.
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