Protein Multifunctionality: Principles and Mechanisms
Authors: Joseph Z. Zaretsky and Daniel H. Wreschner
Publication Date: 15 May 2008
Translational Oncogenomics 2008:3 99-136
Joseph Z. Zaretsky and Daniel H. Wreschner
Department Cell Research and Immunology, George Wise Faculty of Life Sciences, Tel-Aviv University, Ramat-Aviv, Haim Levanon St., 69978 Tel-Aviv, Israel.
Abstract
In the review, the nature of protein multifunctionality is analyzed. In the first part of the review the principles of structural/functional organization of protein are discussed. In the second part, the main mechanisms involved in development of multiple functions on a single gene product(s) are analyzed. The last part represents a number of examples showing that multifunctionality is a basic feature of biologically active proteins.
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