Translational Oncogenomics
Synopsis: An open access, peer reviewed electronic journal that covers novel genetic, epigenetic and molecular pathway information related to clinical cancer.
Indexing: 6 major databases. Pubmed indexing for NIH-funded research.
Processing time: Decision in 2 weeks for 90% of papers.
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Journal: 59132
Most read article: 2874
Editor in chief:
Michael Spinella
ISSN: 1177-2727
Transcription Regulation by Class III Histone Deacetylases (HDACs)—Sirtuins
Authors: Yan Dai and Douglas V. Faller
Publication Date: 23 Apr 2008
Translational Oncogenomics 2008:3 53-65
Yan Dai and Douglas V. Faller
Cancer Research Center and Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, U.S.A.
Abstract
Sirtuins are NAD+-dependent histone deacetylases (Class III HDACs). Recently, Sirtuins have been shown to play important roles, both direct and indirect, in transcriptional regulation. This transcriptional control, through incorporation of Sirtuins into transcription complexes and deacetylation of histones locally at gene promoters, or direct interaction with specific transcription factors, is central to the participation of Sirtuins in multiple diverse processes, including aging, apoptosis, hormone responses, stress tolerance, differentiation, metabolism and development. Here we review the contribution of the Sirtuin family, at multiple molecular levels, to transcriptional regulation.
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