Asymmetrical Weakness Associated with Central Nervous System Involvement in a Patient with Guillain-Barrè Syndrome
Takao Kiriyama1, Makito Hirano1, Susumu Kusunoki2, Daiji Morita2, Minako Hirakawa2, Yasuyo Tonomura1, Takanori Kitauchi1 and Satoshi Ueno1
1Department of Neurology, Nara Medical University school of Medicine, 840 shijo-cho, Kashihara, Nara 634-8522, Japan. 2Department of Neurology, Kinki University school of Medicine.
Abstract
Guillain-Barrè syndrome (GBS) is usually associated with symmetrical weakness, and therefore asymmetrical weakness may confuse diagnosis. We report on a patient with GBS subsequent to Campylobacter jejuni enteritis who had asymmetrical weakness with CNS involvement. The patient tested positive for anti-ganglioside antibodies, including anti-GM1 IgM, anti-GD1b IgG, and anti-GT1a IgG. Patients with GBS can manifest asymmetrical signs and symptoms attributable to CNS involvement. Prompt, accurate diagnosis and treatment of post-C. jejuni GBS is especially important because its prognosis is relatively poor.
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