Yasuyo Kashiwagi, Shunsuke Suzuki, Tao Fujioka, Shingo Oana, Hisashi Kawashima, Kouji Takekuma and Akinori Hoshika

Department of Pediatrics, Tokyo Medical University, Tokyo, Japan.

Abstract

Tubulointerstitial nephritis and uveitis (TINU) syndrome is a rare autoimmune disease and the pathogenesis is still unknown. We report a case of TINU syndrome with high ASLO titer.

Uveitis improved and urine β₂-MG normalized with low dose systemic predonisolone and cyclosporin A. The high ASLO titer in early phase suggested that streptococcal infection might have triggered TINU syndrome. Lymphocyte phenotypes normalized after treatment with low dose systemic predonisolone and cyclosporin A.