Cancer Informatics
Synopsis: An open access, peer reviewed electronic journal that covers the role of computational biology and bioinformatics in cancer treatment.
Indexing: Pubmed, Pubmed Central, CAS, DOAJ, EMBase, SCOPUS, Google Scholar, OAIster
Processing time: Decision in 3 weeks for 95% of papers.
Latest news:
Read an interview with editorial board member Dr Grant Izmirlian
The Bimodality Index: A Criterion for Discovering and Ranking Bimodal Signatures from Cancer Gene Expression Profiling Data
Authors: Jing Wang, Sijin Wen, W. Fraser Symmans, Lajos Pusztai and Kevin R. Coombes
Publication Date: 05 Aug 2009
Cancer Informatics 2009:7 199-216
Jing Wang1, Sijin Wen2, W. Fraser Symmans3, Lajos Pusztai4 and Kevin R. Coombes1
1Department of Bioinformatics and Computational Biology, 2Department of Biostatistics, 3Department of Pathology, 4Department of Breast Medical Oncology, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030-4009.
Abstract
Motivation: Identifying genes with bimodal expression patterns from large-scale expression profiling data is an important analytical task. Model-based clustering is popular for this purpose. That technique commonly uses the Bayesian information criterion (BIC) for model selection. In practice, however, BIC appears to be overly sensitive and may lead to the identification of bimodally expressed genes that are unreliable or not clinically useful. We propose using a novel criterion, the bimodality index, not only to identify but also to rank meaningful and reliable bimodal patterns. The bimodality index can be computed using either a mixture model-based algorithm or Markov chain Monte Carlo techniques.
Results: We carried out simulation studies and applied the method to real data from a cancer gene expression profiling study. Our findings suggest that BIC behaves like a lax cutoff based on the bimodality index, and that the bimodality index provides an objective measure to identify and rank meaningful and reliable bimodal patterns from large-scale gene expression datasets. R code to compute the bimodality index is included in the ClassDiscovery package of the Object-Oriented Microarray and Proteomic Analysis (OOMPA) suite available at the web site http://bioinformatics.mdanderson.org/Software/OOMPA.
Keywords: gene expression profiling, cancer, bimodality index
Readers of this also read:
- The Bimodality Index: A Criterion for Discovering and Ranking Bimodal Signatures from Cancer Gene Expression Profiling Data
- New Advanced Technologies to Provide Decentralised and Secure Access to Medical Records: Case Studies in Oncology
- A Generalized Beta Model for the Age Distribution of Cancers: Application to Pancreatic and Kidney Cancer
- Robust Model Selection for Classification of Microarrays
- PhyLIS: A Simple GNU/Linux Distribution for Phylogenetics and Phyloinformatics
Sign up for free journal updates
Recently published in this journal 
Unblocking Blockbusters: Using Boolean Text-Mining to Optimise Clinical Trial Design and Timeline for Novel Anticancer Drugs
- 17/Aug/2009
New Advanced Technologies to Provide Decentralised and Secure Access to Medical Records: Case Studies in Oncology
- 07/Aug/2009
The Bimodality Index: A Criterion for Discovering and Ranking Bimodal Signatures from Cancer Gene Expression Profiling Data
- 05/Aug/2009
A Generalized Beta Model for the Age Distribution of Cancers: Application to Pancreatic and Kidney Cancer
- 04/Aug/2009
Linguistic Processing and Classification of Semi Structured Bibliographic Data on Complementary Medicine
- 06/Jul/2009
Robust Model Selection for Classification of Microarrays
- 25/Jun/2009
Integration of Neuroimaging and Microarray Datasets through Mapping and Model-Theoretic Semantic Decomposition of Unstructured Phenotypes
- 08/Jun/2009
Microarray-Based Cancer Prediction Using Soft Computing Approach
- 26/May/2009
Using Semantic Web Technologies to Annotate and Align Microarray Designs
- 13/May/2009
Estrogen Exposure, Metabolism, and Enzyme Variants in a Model for Breast Cancer Risk Prediction
- 05/May/2009
Dedication: Joan Elaine Althouse Weiler
- 30/Apr/2009
Development of the Lymphoma Enterprise Architecture Database: A caBIG(TM) Silver Level Compliant System
- 03/Apr/2009
Combining Chromosomal Arm Status and Significantly Aberrant Genomic Locations Reveals New Cancer Subtypes
- 12/Mar/2009
An Algorithm for Identifying Novel Targets of Transcription Factor Families: Application to Hypoxia-inducible Factor 1 Targets
- 04/Mar/2009
Use of Gene Expression Profiles of Peripheral Blood Lymphocytes to Distinguish BRCA1 Mutation Carriers in High Risk Breast Cancer Families
- 02/Mar/2009
A Novel Information Retrieval Model for High-Throughput Molecular Medicine Modalities
- 09/Feb/2009
Staging of Prostate Cancer Using Automatic Feature Selection, Sampling and Dempster-Shafer Fusion
- 03/Feb/2009
Semantic Integration of Cervical Cancer Data Repositories to Facilitate Multicenter Association Studies: The ASSIST Approach
- 03/Feb/2009
Semantic Web-Based Integration of Cancer Pathways and Allele Frequency Data
- 15/Jan/2009
Quantitative Assessment of Tissue Biomarkers and Construction of a Model to Predict Outcome in Breast Cancer Using Multiple Imputation
- 23/Dec/2008
Applications of Microarray Technology to Acute Myelogenous Leukemia
- 22/Dec/2008
Simulation of Different Truncated p16INK4a Forms and In Silico Study of Interaction with Cdk4
- 03/Dec/2008
Modeling and Analyzing Gene Co-Expression in Hepatocellular Carcinoma Using Actor-Semiotic Networks and Centrality Signatures
- 05/Nov/2008
An Analysis Pipeline for Genome-wide Association Studies
- 24/Sep/2008
Algorithmic Discovery of Methylation “Hot Spots” in DNA from Lymphoma Patients
- 04/Sep/2008
Grammatical Immune System Evolution for Reverse Engineering Nonlinear Dynamic Bayesian Models
- 28/Aug/2008
What Does PLIER Really Do?
- 27/Aug/2008
Efficiency Analysis of Competing Tests for Finding Differentially Expressed Genes in Lung Adenocarcinoma
- 14/Jul/2008
A Biological Evaluation of Six Gene Set Analysis Methods for Identification of Differentially Expressed Pathways in Microarray Data
- 20/Jun/2008
An Integrative Analysis of microRNA and mRNA Expression - A Case Study
- 17/Jun/2008
The Anti-tumour Agent, Cisplatin, and its Clinically Ineffective Isomer, Transplatin, Produce Unique Gene Expression Profiles in Human Cells
- 10/Jun/2008
Non-Negative Matrix Factorization for the Analysis of Complex Gene Expression Data: Identification of Clinically Relevant Tumor Subtypes
- 29/May/2008
Detecting Role Errors in the Gene Hierarchy of the NCI Thesaurus
- 27/May/2008
An Analysis of Risk Factors for Developing Hepatocellular Carcinoma in a Group of Hepatitis C Patients with Stage 3 Fibrosis following Interferon Therapy
- 23/Apr/2008
Connections Between ETV6-Modulated Genes: Identification of Shared Features
- 21/Apr/2008
BRB-ArrayTools Data Archive for Human Cancer Gene Expression: A Unique and Efficient Data Sharing Resource
- 21/Apr/2008
Classifying Variants of Undetermined Significance in BRCA2 with Protein Likelihood Ratios
- 18/Apr/2008
Comparison of a Label-Free Quantitative Proteomic Method Based on Peptide Ion Current Area to the Isotope Coded Affinity Tag Method
- 17/Apr/2008
Uncovering Biological Network Function via Graphlet Degree Signatures
- 14/Apr/2008
Bayesian Mass Spectra Peak Alignment from Mass Charge Ratios
- 11/Apr/2008
A Standards based Ontological Approach to Information Handling for use by Organizations Providing Human Tissue for Research
- 10/Apr/2008
Sample Preparation for in vitro Analysis of Iodine in Thyroid Tissue using X-ray Fluorescence
- 10/Apr/2008
An Application of a Service-oriented System to Support ArrayAnnotation in Custom Chip Design for Epigenomic Analysis
- 10/Apr/2008
MCAM: A Database to Accelerate the Identification of Functional Cell Adhesion Molecules
- 31/Mar/2008
Comparisons of Robustness and Sensitivity between Cancer and Normal Cells by Microarray Data
- 28/Mar/2008
DNA Copy Number Analysis in Gastrointestinal Stromal Tumors Using Gene Expression Microarrays
- 27/Mar/2008
Chromosome 20q Amplification Regulates in Vitro Response to Kinesin-5 Inhibitor
- 26/Mar/2008
A Computational Model of Quantitative Chromatin Immunoprecipitation (ChIP) Analysis
- 12/Mar/2008
Effect of Quantitative Nuclear Image Features on Recurrence of Ductal Carcinoma In Situ (DCIS) of the Breast
- 01/Mar/2008
Evaluating Microarray-based Classifiers: An Overview
- 29/Feb/2008
Estimating the Proportion of True Null Hypotheses for Multiple Comparisons
- 14/Feb/2008
Bayesian Estimation of Performance Measures of Cervical Cancer Screening Tests in the Presence of Covariates and Absence of a Gold Standard
- 14/Feb/2008
Global Associations between Copy Number and Transcript mRNA Microarray Data: An Empirical Study
- 09/Feb/2008
Constructing Tumor Progression Pathways and Biomarker Discovery with Fuzzy Kernel Kmeans and DNA Methylation Data
- 25/Jan/2008
Estimating the False Discovery Rate Using Mixed Normal Distribution for Identifying Differentially Expressed Genes in Microarray Data Analysis
- 22/Jan/2008
A Practical Multifaceted Approach to Selecting Differentially Expressed Genes
- 15/Jan/2008
Common Peak Approach Using Mass Spectrometry Data Sets for Predicting the Effects of Anticancer Drugs on Breast Cancer
- 14/Dec/2007
Germinal Center B Cell-Like (GCB) and Activated B Cell-Like (ABC) Type of Diffuse Large B Cell Lymphoma (DLBCL): Analysis of Molecular Predictors, Signatures, Cell Cycle State and Patient Survival
- 12/Dec/2007
Public Databases and Software for the Pathway Analysis of Cancer Genomes
- 12/Dec/2007
Systems Level Modeling of the Cell Cycle Using Budding Yeast
- 11/Dec/2007
Comparison of Computational Algorithms for the Classification of Liver Cancer using SELDI Mass Spectrometry: A Case Study
- 11/Dec/2007
Combining Clinical and Genomic Covariates via Cov-TGDR
- 15/Oct/2007
Tumor Genome Wide DNA Alterations Assessed by Array CGH in Patients with Poor and Excellent Survival Following Operation for Colorectal Cancer
- 12/Oct/2007
Parametric Power Spectral Density Analysis of Noise from Instrumentation in MALDI TOF Mass Spectrometry
- 17/Sep/2007
Normalized, Segmented or Called aCGH Data?
- 17/Sep/2007
Overlay Tool© for aCGHViewer©: An Analysis Module Built for aCGHViewer© used to Perform Comparisons of Data Derived from Different Microarray Platforms
- 08/Aug/2007
Comparison of Supervised Classification Methods for Protein Profiling in Cancer Diagnosis
- 19/Jul/2007
Simultaneous EGFR and VEGF Alterations in Non-Small Cell Lung Carcinoma Based on Tissue Microarrays
- 12/Jun/2007
A Novel Cross-Disciplinary Multi-Institute Approach to Translational Cancer Research: Lessons Learned from Pennsylvania Cancer Alliance Bioinformatics Consortium (PCABC)
- 08/Jun/2007
Decentralized Data Sharing of Tissue Microarrays for Investigative Research in Oncology
- 06/Jun/2007
Spatial Turing-type Pattern Formation in a Model of Signal Transduction Involving Membrane-based Receptors Coupled by G Proteins
- 06/Jun/2007
Investigation of miRNA Biology by Bioinformatic Tools and Impact of miRNAs in Colorectal Cancer: Regulatory Relationship of c-Myc and p53 with miRNAs
- 31/May/2007
An Architecture for Computer-Aided Detection and Radiologic Measurement of Lung Nodules in Clinical Trials
- 12/May/2007
DICOM Structured Reporting and Cancer Clinical Trials Results
- 12/May/2007
Change Detection & Characterization: a New Tool for Imaging Informatics and Cancer Research
- 12/May/2007
Imaging in Clinical Trials
- 12/May/2007
Image Registration Improves Confidence and Accuracy of Image Interpretation
- 12/May/2007
Statistical Issues and Analyses of in vivo and in vitro Genomic Data in order to Identify Clinically Relevant Profiles
- 10/May/2007
Development of Query Strategies to Identify a Histologic Lymphoma Subtype in a Large Linked Database System
- 04/May/2007
Global Tumor RNA Expression in Early Establishment of Experimental Tumor Growth and Related Angiogenesis following Cox-Inhibition Evaluated by Microarray Analysis
- 01/May/2007
Cross-platform Analysis of Cancer Biomarkers: A Bayesian Network Approach to Incorporating Mass Spectrometry and Microarray Data
- 29/Apr/2007
The Roles of β²-Tubulin Mutations and Isotype Expression in Acquired Drug Resistance
- 27/Apr/2007
Cancer as a System Failure
- 03/Apr/2007
Application of Gene Shaving and Mixture Models to Cluster Microarray Gene Expression Data
- 02/Apr/2007
Exploratory Visual Analysis of Statistical Results from Microarray Experiments Comparing High and Low Grade Glioma
- 01/Apr/2007
Perturbation of Interaction Networks for Application to Cancer Therapy
- 01/Apr/2007
Advancing Cancer Systems Biology: Introducing the Center for the Development of a Virtual Tumor, CViT
- 30/Mar/2007
Feature Selection for Predicting Tumor Metastases in Microarray Experiments using Paired Design
- 20/Mar/2007
Comparison of Predicted Probabilities of Proportional Hazards Regression and Linear Discriminant Analysis Methods Using a Colorectal Cancer Molecular Biomarker Database
- 02/Mar/2007
Standards of Excellence and Open Questions in Cancer Biomarker Research: An Informatics Perspective
- 28/Feb/2007
Plasma Protein Profiles Differ Between Women Diagnosed with Cervical Intraepithelial Neoplasia (CIN) 1 and 3
- 27/Feb/2007
Dedication: Sarah Amy Hill
- 27/Feb/2007
Cancer Informatics in the U.K.: The NCRI Informatics Initiative
- 26/Feb/2007
Bias, Randomization, and Ovarian Proteomic Data: A Reply to "Producers and Consumers"
- 26/Feb/2007
Application of a New Probabilistic Model for Mining Implicit Associated Cancer Genes from OMIM and Medline
- 25/Feb/2007
Design of Early Validation Trials of Biomarkers
- 25/Feb/2007
Detecting Outlier Microarray Arrays by Correlation and Percentage of Outliers Spots
- 24/Feb/2007
Proteomics: Analysis of Spectral Data
- 24/Feb/2007
An Empirical Study of Univariate and Genetic Algorithm-Based Feature Selection in Binary Classification with Microarray Data
- 23/Feb/2007
Characterising phase variations in MALDI-TOF data and correcting them by peak alignment
- 23/Feb/2007
- 17/Aug/2009
New Advanced Technologies to Provide Decentralised and Secure Access to Medical Records: Case Studies in Oncology
- 07/Aug/2009
The Bimodality Index: A Criterion for Discovering and Ranking Bimodal Signatures from Cancer Gene Expression Profiling Data
- 05/Aug/2009
A Generalized Beta Model for the Age Distribution of Cancers: Application to Pancreatic and Kidney Cancer
- 04/Aug/2009
Linguistic Processing and Classification of Semi Structured Bibliographic Data on Complementary Medicine
- 06/Jul/2009
Robust Model Selection for Classification of Microarrays
- 25/Jun/2009
Integration of Neuroimaging and Microarray Datasets through Mapping and Model-Theoretic Semantic Decomposition of Unstructured Phenotypes
- 08/Jun/2009
Microarray-Based Cancer Prediction Using Soft Computing Approach
- 26/May/2009
Using Semantic Web Technologies to Annotate and Align Microarray Designs
- 13/May/2009
Estrogen Exposure, Metabolism, and Enzyme Variants in a Model for Breast Cancer Risk Prediction
- 05/May/2009
Dedication: Joan Elaine Althouse Weiler
- 30/Apr/2009
Development of the Lymphoma Enterprise Architecture Database: A caBIG(TM) Silver Level Compliant System
- 03/Apr/2009
Combining Chromosomal Arm Status and Significantly Aberrant Genomic Locations Reveals New Cancer Subtypes
- 12/Mar/2009
An Algorithm for Identifying Novel Targets of Transcription Factor Families: Application to Hypoxia-inducible Factor 1 Targets
- 04/Mar/2009
Use of Gene Expression Profiles of Peripheral Blood Lymphocytes to Distinguish BRCA1 Mutation Carriers in High Risk Breast Cancer Families
- 02/Mar/2009
A Novel Information Retrieval Model for High-Throughput Molecular Medicine Modalities
- 09/Feb/2009
Staging of Prostate Cancer Using Automatic Feature Selection, Sampling and Dempster-Shafer Fusion
- 03/Feb/2009
Semantic Integration of Cervical Cancer Data Repositories to Facilitate Multicenter Association Studies: The ASSIST Approach
- 03/Feb/2009
Semantic Web-Based Integration of Cancer Pathways and Allele Frequency Data
- 15/Jan/2009
Quantitative Assessment of Tissue Biomarkers and Construction of a Model to Predict Outcome in Breast Cancer Using Multiple Imputation
- 23/Dec/2008
Applications of Microarray Technology to Acute Myelogenous Leukemia
- 22/Dec/2008
Simulation of Different Truncated p16INK4a Forms and In Silico Study of Interaction with Cdk4
- 03/Dec/2008
Modeling and Analyzing Gene Co-Expression in Hepatocellular Carcinoma Using Actor-Semiotic Networks and Centrality Signatures
- 05/Nov/2008
An Analysis Pipeline for Genome-wide Association Studies
- 24/Sep/2008
Algorithmic Discovery of Methylation “Hot Spots” in DNA from Lymphoma Patients
- 04/Sep/2008
Grammatical Immune System Evolution for Reverse Engineering Nonlinear Dynamic Bayesian Models
- 28/Aug/2008
What Does PLIER Really Do?
- 27/Aug/2008
Efficiency Analysis of Competing Tests for Finding Differentially Expressed Genes in Lung Adenocarcinoma
- 14/Jul/2008
A Biological Evaluation of Six Gene Set Analysis Methods for Identification of Differentially Expressed Pathways in Microarray Data
- 20/Jun/2008
An Integrative Analysis of microRNA and mRNA Expression - A Case Study
- 17/Jun/2008
The Anti-tumour Agent, Cisplatin, and its Clinically Ineffective Isomer, Transplatin, Produce Unique Gene Expression Profiles in Human Cells
- 10/Jun/2008
Non-Negative Matrix Factorization for the Analysis of Complex Gene Expression Data: Identification of Clinically Relevant Tumor Subtypes
- 29/May/2008
Detecting Role Errors in the Gene Hierarchy of the NCI Thesaurus
- 27/May/2008
An Analysis of Risk Factors for Developing Hepatocellular Carcinoma in a Group of Hepatitis C Patients with Stage 3 Fibrosis following Interferon Therapy
- 23/Apr/2008
Connections Between ETV6-Modulated Genes: Identification of Shared Features
- 21/Apr/2008
BRB-ArrayTools Data Archive for Human Cancer Gene Expression: A Unique and Efficient Data Sharing Resource
- 21/Apr/2008
Classifying Variants of Undetermined Significance in BRCA2 with Protein Likelihood Ratios
- 18/Apr/2008
Comparison of a Label-Free Quantitative Proteomic Method Based on Peptide Ion Current Area to the Isotope Coded Affinity Tag Method
- 17/Apr/2008
Uncovering Biological Network Function via Graphlet Degree Signatures
- 14/Apr/2008
Bayesian Mass Spectra Peak Alignment from Mass Charge Ratios
- 11/Apr/2008
A Standards based Ontological Approach to Information Handling for use by Organizations Providing Human Tissue for Research
- 10/Apr/2008
Sample Preparation for in vitro Analysis of Iodine in Thyroid Tissue using X-ray Fluorescence
- 10/Apr/2008
An Application of a Service-oriented System to Support ArrayAnnotation in Custom Chip Design for Epigenomic Analysis
- 10/Apr/2008
MCAM: A Database to Accelerate the Identification of Functional Cell Adhesion Molecules
- 31/Mar/2008
Comparisons of Robustness and Sensitivity between Cancer and Normal Cells by Microarray Data
- 28/Mar/2008
DNA Copy Number Analysis in Gastrointestinal Stromal Tumors Using Gene Expression Microarrays
- 27/Mar/2008
Chromosome 20q Amplification Regulates in Vitro Response to Kinesin-5 Inhibitor
- 26/Mar/2008
A Computational Model of Quantitative Chromatin Immunoprecipitation (ChIP) Analysis
- 12/Mar/2008
Effect of Quantitative Nuclear Image Features on Recurrence of Ductal Carcinoma In Situ (DCIS) of the Breast
- 01/Mar/2008
Evaluating Microarray-based Classifiers: An Overview
- 29/Feb/2008
Estimating the Proportion of True Null Hypotheses for Multiple Comparisons
- 14/Feb/2008
Bayesian Estimation of Performance Measures of Cervical Cancer Screening Tests in the Presence of Covariates and Absence of a Gold Standard
- 14/Feb/2008
Global Associations between Copy Number and Transcript mRNA Microarray Data: An Empirical Study
- 09/Feb/2008
Constructing Tumor Progression Pathways and Biomarker Discovery with Fuzzy Kernel Kmeans and DNA Methylation Data
- 25/Jan/2008
Estimating the False Discovery Rate Using Mixed Normal Distribution for Identifying Differentially Expressed Genes in Microarray Data Analysis
- 22/Jan/2008
A Practical Multifaceted Approach to Selecting Differentially Expressed Genes
- 15/Jan/2008
Common Peak Approach Using Mass Spectrometry Data Sets for Predicting the Effects of Anticancer Drugs on Breast Cancer
- 14/Dec/2007
Germinal Center B Cell-Like (GCB) and Activated B Cell-Like (ABC) Type of Diffuse Large B Cell Lymphoma (DLBCL): Analysis of Molecular Predictors, Signatures, Cell Cycle State and Patient Survival
- 12/Dec/2007
Public Databases and Software for the Pathway Analysis of Cancer Genomes
- 12/Dec/2007
Systems Level Modeling of the Cell Cycle Using Budding Yeast
- 11/Dec/2007
Comparison of Computational Algorithms for the Classification of Liver Cancer using SELDI Mass Spectrometry: A Case Study
- 11/Dec/2007
Combining Clinical and Genomic Covariates via Cov-TGDR
- 15/Oct/2007
Tumor Genome Wide DNA Alterations Assessed by Array CGH in Patients with Poor and Excellent Survival Following Operation for Colorectal Cancer
- 12/Oct/2007
Parametric Power Spectral Density Analysis of Noise from Instrumentation in MALDI TOF Mass Spectrometry
- 17/Sep/2007
Normalized, Segmented or Called aCGH Data?
- 17/Sep/2007
Overlay Tool© for aCGHViewer©: An Analysis Module Built for aCGHViewer© used to Perform Comparisons of Data Derived from Different Microarray Platforms
- 08/Aug/2007
Comparison of Supervised Classification Methods for Protein Profiling in Cancer Diagnosis
- 19/Jul/2007
Simultaneous EGFR and VEGF Alterations in Non-Small Cell Lung Carcinoma Based on Tissue Microarrays
- 12/Jun/2007
A Novel Cross-Disciplinary Multi-Institute Approach to Translational Cancer Research: Lessons Learned from Pennsylvania Cancer Alliance Bioinformatics Consortium (PCABC)
- 08/Jun/2007
Decentralized Data Sharing of Tissue Microarrays for Investigative Research in Oncology
- 06/Jun/2007
Spatial Turing-type Pattern Formation in a Model of Signal Transduction Involving Membrane-based Receptors Coupled by G Proteins
- 06/Jun/2007
Investigation of miRNA Biology by Bioinformatic Tools and Impact of miRNAs in Colorectal Cancer: Regulatory Relationship of c-Myc and p53 with miRNAs
- 31/May/2007
An Architecture for Computer-Aided Detection and Radiologic Measurement of Lung Nodules in Clinical Trials
- 12/May/2007
DICOM Structured Reporting and Cancer Clinical Trials Results
- 12/May/2007
Change Detection & Characterization: a New Tool for Imaging Informatics and Cancer Research
- 12/May/2007
Imaging in Clinical Trials
- 12/May/2007
Image Registration Improves Confidence and Accuracy of Image Interpretation
- 12/May/2007
Statistical Issues and Analyses of in vivo and in vitro Genomic Data in order to Identify Clinically Relevant Profiles
- 10/May/2007
Development of Query Strategies to Identify a Histologic Lymphoma Subtype in a Large Linked Database System
- 04/May/2007
Global Tumor RNA Expression in Early Establishment of Experimental Tumor Growth and Related Angiogenesis following Cox-Inhibition Evaluated by Microarray Analysis
- 01/May/2007
Cross-platform Analysis of Cancer Biomarkers: A Bayesian Network Approach to Incorporating Mass Spectrometry and Microarray Data
- 29/Apr/2007
The Roles of β²-Tubulin Mutations and Isotype Expression in Acquired Drug Resistance
- 27/Apr/2007
Cancer as a System Failure
- 03/Apr/2007
Application of Gene Shaving and Mixture Models to Cluster Microarray Gene Expression Data
- 02/Apr/2007
Exploratory Visual Analysis of Statistical Results from Microarray Experiments Comparing High and Low Grade Glioma
- 01/Apr/2007
Perturbation of Interaction Networks for Application to Cancer Therapy
- 01/Apr/2007
Advancing Cancer Systems Biology: Introducing the Center for the Development of a Virtual Tumor, CViT
- 30/Mar/2007
Feature Selection for Predicting Tumor Metastases in Microarray Experiments using Paired Design
- 20/Mar/2007
Comparison of Predicted Probabilities of Proportional Hazards Regression and Linear Discriminant Analysis Methods Using a Colorectal Cancer Molecular Biomarker Database
- 02/Mar/2007
Standards of Excellence and Open Questions in Cancer Biomarker Research: An Informatics Perspective
- 28/Feb/2007
Plasma Protein Profiles Differ Between Women Diagnosed with Cervical Intraepithelial Neoplasia (CIN) 1 and 3
- 27/Feb/2007
Dedication: Sarah Amy Hill
- 27/Feb/2007
Cancer Informatics in the U.K.: The NCRI Informatics Initiative
- 26/Feb/2007
Bias, Randomization, and Ovarian Proteomic Data: A Reply to "Producers and Consumers"
- 26/Feb/2007
Application of a New Probabilistic Model for Mining Implicit Associated Cancer Genes from OMIM and Medline
- 25/Feb/2007
Design of Early Validation Trials of Biomarkers
- 25/Feb/2007
Detecting Outlier Microarray Arrays by Correlation and Percentage of Outliers Spots
- 24/Feb/2007
Proteomics: Analysis of Spectral Data
- 24/Feb/2007
An Empirical Study of Univariate and Genetic Algorithm-Based Feature Selection in Binary Classification with Microarray Data
- 23/Feb/2007
Characterising phase variations in MALDI-TOF data and correcting them by peak alignment
- 23/Feb/2007
Related journals...
Cancer Informatics
James Willey , Editor in Chief
Submit a paper
Share this journal
 |
|
 |
YAHOO! BUZZ |
 |
DIGG |
 |
|
 |
MIXX |
 |
PERMALINK |
 |
GOOGLE BOOKMARKS |
 |
DELICIOUS |
 |
|
 |
NEWSVINE |
Recent news
Call for papers for Advances in Tumor Virology from Dr Frank J Jenkins - 13/Oct/2009
International Journal of Insect Science indexed by CABI - 13/Oct/2009
Interview with Biomarker Insights editorial board member Dr Paul Lampe - 13/Oct/2009
Perspectives in Medicinal Chemistry now indexed by Pubmed - 13/Oct/2009
Gene Regulation and Systems Biology now indexed by Pubmed - 13/Oct/2009
Interview with Clinical Medicine: Cardiology editorial board member Dr Francisco R. Breijo-Márquez - 12/Oct/2009
Articles published in week 41 (October 5 to 11) - 12/Oct/2009
Research profile on Clinical Medicine: Arthritis and Musculoskeletal Disorders editorial board member Dr Axel Finckh - 09/Oct/2009
Interview with Clinical Medicine: Oncology editorial board member Dr Daniela Bota - 08/Oct/2009
Interview with International Journal of Pain editorial board member Dr Raymond Tait - 08/Oct/2009
Interview with Evolutionary Bioinformatics editorial board member Dr John Hancock - 06/Oct/2009
Interview with Clinical Medicine: Circulatory, Respiratory and Pulmonary Medicine editorial board member Dr Lee Morrow - 05/Oct/2009
Articles Published in Week 40 (September 28 to October 2) - 05/Oct/2009
Open access articles published in September - 02/Oct/2009
Announcing Biomedical Engineering and Computational Biology - 30/Sep/2009
Announcing the Indian Journal of Clinical Medicine - 30/Sep/2009
Autism Insights launched - 29/Sep/2009
Newsletter summary (week 37, 2009) - 25/Sep/2009
Interview with Clinical Medicine: Cardiology editorial board member Dr Vernon Barnes - 12/Oct/2009
Interview with Cancer Informatics editorial board member Dr Grant Izmirlian - 22/Sep/2009
International Journal of Insect Science indexed by CABI - 13/Oct/2009
Interview with Biomarker Insights editorial board member Dr Paul Lampe - 13/Oct/2009
Perspectives in Medicinal Chemistry now indexed by Pubmed - 13/Oct/2009
Gene Regulation and Systems Biology now indexed by Pubmed - 13/Oct/2009
Interview with Clinical Medicine: Cardiology editorial board member Dr Francisco R. Breijo-Márquez - 12/Oct/2009
Articles published in week 41 (October 5 to 11) - 12/Oct/2009
Research profile on Clinical Medicine: Arthritis and Musculoskeletal Disorders editorial board member Dr Axel Finckh - 09/Oct/2009
Interview with Clinical Medicine: Oncology editorial board member Dr Daniela Bota - 08/Oct/2009
Interview with International Journal of Pain editorial board member Dr Raymond Tait - 08/Oct/2009
Interview with Evolutionary Bioinformatics editorial board member Dr John Hancock - 06/Oct/2009
Interview with Clinical Medicine: Circulatory, Respiratory and Pulmonary Medicine editorial board member Dr Lee Morrow - 05/Oct/2009
Articles Published in Week 40 (September 28 to October 2) - 05/Oct/2009
Open access articles published in September - 02/Oct/2009
Announcing Biomedical Engineering and Computational Biology - 30/Sep/2009
Announcing the Indian Journal of Clinical Medicine - 30/Sep/2009
Autism Insights launched - 29/Sep/2009
Newsletter summary (week 37, 2009) - 25/Sep/2009
Interview with Clinical Medicine: Cardiology editorial board member Dr Vernon Barnes - 12/Oct/2009
Interview with Cancer Informatics editorial board member Dr Grant Izmirlian - 22/Sep/2009
Similar papers
Introductory Editorial (Biomedical Engineering and Computational Biology) - 15/Oct/2009
Biomarkers of Adiponectin: Plasma Protein Variation and Genomic DNA Polymorphisms - 13/Oct/2009
VEGF 936C > T Polymorphism and Association of BI-RADS Score in Women with Suspected Breast Cancer - 06/Oct/2009
A Rough Set-Based Model of HIV-1 Reverse Transcriptase Resistome - 05/Oct/2009
Genome-Wide Identification and Evolutionary Analysis of the Animal Specific ETS Transcription Factor Family - 02/Oct/2009
Dysfunction of Corticomotoneurons in Guillain-Barré Syndrome (GBS)? - 01/Oct/2009
Changes in Plasma IL-6, Plasma VEGF and Serum YKL-40 During Treatment with Etanercept and Methotrexate or Etanercept Alone in Patients with Active Rheumatoid Arthritis Despite Methotrexate Therapy - 29/Sep/2009
Graphical User Interfaces for Molecular Dynamics—Quo Vadis? - 23/Sep/2009
Metabolic Complications of Bypass Surgery for Morbid Obesity - 18/Sep/2009
The Metastasectomy and Timing of Pulmonary Metastases on the Outcome of Osteosarcoma Patients - 14/Sep/2009
Gromita: A Fully Integrated Graphical User Interface to Gromacs 4 - 07/Sep/2009
Gene Expression Based Leukemia Sub‑Classification Using Committee Neural Networks - 03/Sep/2009
Asymmetrical Weakness Associated with Central Nervous System Involvement in a Patient with Guillain-Barrè Syndrome - 03/Sep/2009
Modulation of the BRCA1 Protein and Induction of Apoptosis in Triple Negative Breast Cancer Cell Lines by the Polyphenolic Compound Curcumin - 02/Sep/2009
A Model for Protein Sequence Evolution Based on Selective Pressure for Protein Stability: Application to Hemoglobins - 27/Aug/2009
Biomarkers of Adiponectin: Plasma Protein Variation and Genomic DNA Polymorphisms - 13/Oct/2009
VEGF 936C > T Polymorphism and Association of BI-RADS Score in Women with Suspected Breast Cancer - 06/Oct/2009
A Rough Set-Based Model of HIV-1 Reverse Transcriptase Resistome - 05/Oct/2009
Genome-Wide Identification and Evolutionary Analysis of the Animal Specific ETS Transcription Factor Family - 02/Oct/2009
Dysfunction of Corticomotoneurons in Guillain-Barré Syndrome (GBS)? - 01/Oct/2009
Changes in Plasma IL-6, Plasma VEGF and Serum YKL-40 During Treatment with Etanercept and Methotrexate or Etanercept Alone in Patients with Active Rheumatoid Arthritis Despite Methotrexate Therapy - 29/Sep/2009
Graphical User Interfaces for Molecular Dynamics—Quo Vadis? - 23/Sep/2009
Metabolic Complications of Bypass Surgery for Morbid Obesity - 18/Sep/2009
The Metastasectomy and Timing of Pulmonary Metastases on the Outcome of Osteosarcoma Patients - 14/Sep/2009
Gromita: A Fully Integrated Graphical User Interface to Gromacs 4 - 07/Sep/2009
Gene Expression Based Leukemia Sub‑Classification Using Committee Neural Networks - 03/Sep/2009
Asymmetrical Weakness Associated with Central Nervous System Involvement in a Patient with Guillain-Barrè Syndrome - 03/Sep/2009
Modulation of the BRCA1 Protein and Induction of Apoptosis in Triple Negative Breast Cancer Cell Lines by the Polyphenolic Compound Curcumin - 02/Sep/2009
A Model for Protein Sequence Evolution Based on Selective Pressure for Protein Stability: Application to Hemoglobins - 27/Aug/2009