Gene Regulation and Systems Biology
Synopsis: An open access, peer reviewed electronic journal that covers regulation of genes and proteins they encode and the broader field of systems biology.
Indexing: 8 major databases. Pubmed indexing for NIH-funded research.
Processing time: Decision in 2 weeks for 90% of papers.
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Journal newsletter sent to subscribers in week 37, 2009. Follow link to see newsletter summary. Register to receive newsletters.
Multi-Target Approaches in Colon Cancer Chemoprevention Based on Systems Biology of Tumor Cell-Signaling
Authors: Suresh Guruswamy and Chinthalapally V. Rao
Publication Date: 02 May 2008
Gene Regulation and Systems Biology 2008:2 163-176
Suresh Guruswamy and Chinthalapally V. Rao
Department of Medicine, Hematology-Oncology Section, University of Oklahoma Health Sciences Center, Oklahoma City, OK, U.S.A.
Abstract
Colorectal cancer is the leading cause of cancer related deaths in the United States. Although it is preventable, thousands of lives are lost each year in the U.S. to colorectal cancer than to breast cancer and AIDS combined. In colon cancer, the formation and progression of precancerous lesions like aberrant crypt foci and polyps is associated with the up- regulation of cycloxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS) and hydroxy methyl glutaryl CoA reductase (HMG-CoA reductase). The current review will focus on the signaling pathway involving COX-2 and HMG-CoA reductase enzymes and their downstream effectors in signaling mechanism. Cancer cells need huge pools of both cholesterol and isoprenoids to sustain their unlimited growth potential. Cholesterol by modulating caveolae formation regulates several signaling molecules like AKT, IGFR, EGFR and Rho which are involved in cell growth and survival. Cholesterol is also essential for lipid body formation which serves as storage sites for COX-2, eicosanoids and caveolin-1. Experimental studies have identifi ed important mechanisms showing that COX-2, caveolin-1, lipid bodies and prenylated proteins is involved in carcinogenesis. Therefore multi-target, multi-drug approach is the ideal choice for effective colon cancer chemoprevention. This review will give an overview of the two pathways, their signaling networks, and the interactions between the components of the two networks in the activation and regulation of cell signaling involving growth/survival and explain the rationale for colon cancer chemoprevention using COX-2 inhibitors and statins.
Keywords: colon cancer, chemoprevention, COX-2, HMG-CoA reductase, caveolae
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Newsletter summary (week 37, 2009) - 25/Sep/2009
Interview with Cancer Informatics editorial board member Dr Grant Izmirlian - 22/Sep/2009
Call for papers for Analytical Chemistry Insights from Dr Gabor Patonay - 22/Sep/2009
Sponsor the IBM-OCI Integrative Discovery team in Ride to Conquer Cancer - 15/Sep/2009
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Newsletter summary (week 36, 2009) - 15/Sep/2009
Interview with Healthy Aging and Clinical Care in the Elderly editorial board member Dr Davide Malatesta - 15/Sep/2009
Interview with Translational Oncogenomics author Dr David Frank - 10/Sep/2009
Interview with Retrovirology: Research and Treatment author Dr Elcio Leal - 10/Sep/2009
Interview with Microbiology Insights author Dr Tinatin Doolotkedlieva - 10/Sep/2009
Call for papers for Drug Target Insights by Dr Monica Milani - 10/Sep/2009
Call for papers for Clinical Medicine: Urology from Dr Xiangyi Lu - 10/Sep/2009
Research profile on Gene Regulation and Systems Biology author Dr Noboru Uchide - 09/Sep/2009
Interview with Biomarker Insights editorial board member Dr Lawrence Cheskin - 07/Sep/2009
Newsletter summary (week 35, 2009) - 04/Sep/2009
Research profile of Clinical Medicine: Endocrinology and Diabetes author Dr Hiro Koshiyama - 04/Sep/2009
Open access articles published in August - 03/Sep/2009
Call for papers for Clinical Medicine: Circulatory, Respiratory and Pulmonary Medicine from Dr Hussein Foda - 03/Sep/2009
Interview with Cancer Informatics editorial board member Dr Georgios S. Stamatakos - 03/Sep/2009
Announcing mobile Libertas Academica website - 02/Sep/2009
Interview with Cancer Informatics editorial board member Dr Grant Izmirlian - 22/Sep/2009
Call for papers for Analytical Chemistry Insights from Dr Gabor Patonay - 22/Sep/2009
Sponsor the IBM-OCI Integrative Discovery team in Ride to Conquer Cancer - 15/Sep/2009
No article processing fees for selected journals - 25/Sep/2009
Newsletter summary (week 36, 2009) - 15/Sep/2009
Interview with Healthy Aging and Clinical Care in the Elderly editorial board member Dr Davide Malatesta - 15/Sep/2009
Interview with Translational Oncogenomics author Dr David Frank - 10/Sep/2009
Interview with Retrovirology: Research and Treatment author Dr Elcio Leal - 10/Sep/2009
Interview with Microbiology Insights author Dr Tinatin Doolotkedlieva - 10/Sep/2009
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Open access articles published in August - 03/Sep/2009
Call for papers for Clinical Medicine: Circulatory, Respiratory and Pulmonary Medicine from Dr Hussein Foda - 03/Sep/2009
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