Letter to the Editor: Does Dicer Expression Affect shRNA Processing?
Authors: Neil Senzer, Donald Rao and John Nemunaitis
Publication Date: 19 Jun 2009
Gene Regulation and Systems Biology 2009:3 103-104
Neil Senzer1, Donald Rao2 and John Nemunaitis1
1Mary Crowley Cancer Research Centers, Dallas, TX. 2Gradalis, Inc., Carrollton, TX.
Abstract
Elevated Dicer and Drosha mRNA levels have been documented across a range of tumor types (including ovarian carcinoma) by a number of investigators without any demonstrable correlation with patient survival nor evidence of interference with shRNA processing. A recent publication by Merritt et al. (NEJM 359(25):2641-50, 2008) reporting their findings in patients with ovarian carcinoma reach opposite conclusions. Further study will be needed to resolve this issue.
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