Biomarker Insights
Synopsis: An open access, peer reviewed electronic journal that covers all aspects of biomarker research and clinical applications.
Indexing: Pubmed, Pubmed Central, EBSCO Academic Research Complete, Embase, Embiology, SCOPUS, Google Scholar, CAS, DOAJ, OAIster.
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Journal: 175597
Most read article: 2146
Editor in chief:
Stephen F Kingsmore
ISSN: 1177-2719
Negative Regulation of Receptor Tyrosine Kinase (RTK) Signaling: A Developing Field
Authors: Fernanda Ledda and Gustavo Paratcha
Publication Date: 14 Feb 2007
Biomarker Insights 2007:2 45-58
Fernanda Ledda and Gustavo Paratcha
Laboratory of Molecular and Cellular Neuroscience, Department of Neuroscience, Karolinska Institute, Retzius väg 8, 17177, Stockholm, Sweden.
Abstract: Trophic factors control cellular physiology by activating specific receptor tyrosine kinases (RTKs). While the over activation of RTK signaling pathways is associated with cell growth and cancer, recent findings support the concept that impaired down-regulation or deactivation of RTKs may also be a mechanism involved in tumor formation. Under this perspective, the molecular determinants of RTK signaling inhibition may act as tumor-suppressor genes and have a potential role as tumor markers to monitor and predict disease progression. Here, we review the current understanding of the physiological mechanisms that attenuate RTK signaling and discuss evidence that implicates deregulation of these events in cancer.
Abbreviations: BDP1: Brain-derived phosphatase 1; Cbl: Casitas B-lineage lymphoma; CIN-85: Cbl-interacting protein of 85 kDa; DER: Drosophila EGFR; EGFR: Epidermal growth factor receptor; ERK 1/2: Extracellular signal-regulated kinase 1/2; Grb2: Growth factor receptor-bound protein 2; HER2: Human epidermal growth factor receptor 2; LRIG: Leucine-rich repeats and immunoglobulin-like domain 1; MAPK: Mitogen-activated protein kinase; Mig 6: Mitogen-inducible gene 6; PTEN: Phosphatase and tensin homologue; RET: Rearranged in transformation; RTK: Receptor tyrosine kinase. SH2 domain: Src-homology 2 domain; SH3 domain: Src-homology 3 domain; Spry: Sprouty.
Keywords: Receptor tyrosine kinases (RTKs); Trophic factors, signal transduction, negative control and cancer.
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Research profile on Gene Regulation and Systems Biology author Dr Noboru Uchide - 09/Sep/2009
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A Rough Set-Based Model of HIV-1 Reverse Transcriptase Resistome - 05/Oct/2009
Genome-Wide Identification and Evolutionary Analysis of the Animal Specific ETS Transcription Factor Family - 02/Oct/2009
Graphical User Interfaces for Molecular Dynamics—Quo Vadis? - 23/Sep/2009
Gromita: A Fully Integrated Graphical User Interface to Gromacs 4 - 07/Sep/2009
Gene Expression Based Leukemia Sub‑Classification Using Committee Neural Networks - 03/Sep/2009
A Model for Protein Sequence Evolution Based on Selective Pressure for Protein Stability: Application to Hemoglobins - 27/Aug/2009
Unblocking Blockbusters: Using Boolean Text-Mining to Optimise Clinical Trial Design and Timeline for Novel Anticancer Drugs - 17/Aug/2009
New Advanced Technologies to Provide Decentralised and Secure Access to Medical Records: Case Studies in Oncology - 07/Aug/2009
The Bimodality Index: A Criterion for Discovering and Ranking Bimodal Signatures from Cancer Gene Expression Profiling Data - 05/Aug/2009
A Generalized Beta Model for the Age Distribution of Cancers: Application to Pancreatic and Kidney Cancer - 04/Aug/2009
On the Use of Bootstrapped Topologies in Coalescent-Based Bayesian MCMC Inference: A Comparison of Estimation and Computational Efficiencies - 31/Jul/2009
PhyLIS: A Simple GNU/Linux Distribution for Phylogenetics and Phyloinformatics - 30/Jul/2009
affyPara - a Bioconductor Package for Parallelized Preprocessing Algorithms of Affymetrix Microarray Data - 22/Jul/2009
Linguistic Processing and Classification of Semi Structured Bibliographic Data on Complementary Medicine - 06/Jul/2009
A Comprehensive Analysis of Gene Expression Evolution Between Humans and Mice - 06/Jul/2009
Genome-Wide Identification and Evolutionary Analysis of the Animal Specific ETS Transcription Factor Family - 02/Oct/2009
Graphical User Interfaces for Molecular Dynamics—Quo Vadis? - 23/Sep/2009
Gromita: A Fully Integrated Graphical User Interface to Gromacs 4 - 07/Sep/2009
Gene Expression Based Leukemia Sub‑Classification Using Committee Neural Networks - 03/Sep/2009
A Model for Protein Sequence Evolution Based on Selective Pressure for Protein Stability: Application to Hemoglobins - 27/Aug/2009
Unblocking Blockbusters: Using Boolean Text-Mining to Optimise Clinical Trial Design and Timeline for Novel Anticancer Drugs - 17/Aug/2009
New Advanced Technologies to Provide Decentralised and Secure Access to Medical Records: Case Studies in Oncology - 07/Aug/2009
The Bimodality Index: A Criterion for Discovering and Ranking Bimodal Signatures from Cancer Gene Expression Profiling Data - 05/Aug/2009
A Generalized Beta Model for the Age Distribution of Cancers: Application to Pancreatic and Kidney Cancer - 04/Aug/2009
On the Use of Bootstrapped Topologies in Coalescent-Based Bayesian MCMC Inference: A Comparison of Estimation and Computational Efficiencies - 31/Jul/2009
PhyLIS: A Simple GNU/Linux Distribution for Phylogenetics and Phyloinformatics - 30/Jul/2009
affyPara - a Bioconductor Package for Parallelized Preprocessing Algorithms of Affymetrix Microarray Data - 22/Jul/2009
Linguistic Processing and Classification of Semi Structured Bibliographic Data on Complementary Medicine - 06/Jul/2009
A Comprehensive Analysis of Gene Expression Evolution Between Humans and Mice - 06/Jul/2009