Biomarker Insights
Synopsis: An open access, peer reviewed electronic journal that covers all aspects of biomarker research and clinical applications.
Indexing: Pubmed, Pubmed Central, EBSCO Academic Research Complete, Embase, Embiology, SCOPUS, Google Scholar, CAS, DOAJ, OAIster.
Processing time: Decision in 2 weeks for 90% of papers.
Visibility: Most popular article read 1400+ times.
About this journal
Aims and scope:
Biomarker Insights is a peer-reviewed, open-access research journal where those engaged in biomarker research can turn for rapid communication of the latest advances in the application of biomarkers toward the discovery of new knowledge, and toward the clinical translation of that knowledge to increase the efficacy of practicing clinicians. Papers submitted for review in Biomarker Insights should focus on the following areas:
- Biomarkers as tools in decision making
- Regulatory acceptance of biomarkers
- Biomarker development and validation
- Role of collaborations and consortia in biomarker advancement
- The "Economics" Behind Personalized Medicine and Pharmacogenomics
- Toxicity biomarkers, toxicogenomics
- Biomarkers for early efficacy assessment
- Genetic biomarkers; genomic biomarkers
- Protein biomarkers
- Metabolomic biomarkers
- Pathway analysis
- Biomarkers in clinical pharmacology
- Biomarkers for clinical safety assessment
- Clinical pharmacogenomics
- Biomarkers to monitor and predict disease progression and response to therapy
- Clinical validation of biomarkers
- Patient selection
- Biomarkers as surrogate end-points
- Biomarkers as indications for drug therapy
- Biomarker assay development and validation
- Outcome diagnostics
- Cancer diagnostics
- Monitoring response to therapy
- Discovery-to-Diagnostic translation
- Clinical Proteomics: potential of proteomic technologies in diagnostics
- Expression signatures as diagnostic/prognostic tools
- Imaging biomarkers pharmacodiagnostics, companion diagnostics
- Integration of biomarkers into clinical practice guidelines and clinical decision support systems
- Integration of biomarkers into mathematical models and algorithms
Editorial standards and procedures:
Submissions, excluding editorials, letters to the editor and dedications, will be peer reviewed by two reviewers. Reviewers are required to provide fair, balanced and constructive reports.
Under our Fairness in Peer Review Policy authors may appeal against reviewers' recommendations which are ill-founded, unobjective or unfair. Appeals are considered by the Editor in Chief or Associate Editor.
Papers are not sent to peer reviewers following submission of a revised manuscript. Editorial decisions on re-submitted papers are based on the author's response to the initial peer review report.
Indexing:
This journal is indexed by the following services:
- Pubmed
- Pubmed Central
- EBSCO Academic Research Complete
- Embase
- Embiology
- SCOPUS
- Google Scholar
- CAS
- DOAJ
- OAIster
SPARC Europe Seal award winner:
This journal has been awarded a SPARC Europe Seal. The Seal is an initiative of SPARC Europe (Scholarly Publishing and Academic Resources Coalition) and the Directory of Open Access Journals (DOAJ) which is awarded to journals applying a Creative Commons CC-BY copyright license and that make journal metadata accessible to DOAJ.
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National Institutes of Health Public Access Policy compliant:
As of April 7 2008, the US NIH Public Access Policy requires that all peer reviewed articles resulting from research carried out with NIH funding be deposited in the Pubmed Central archive.
If you are an NIH employee or grantee Libertas Academica will ensure that you comply with the policy by depositing your paper at Pubmed Central on your behalf.
Call for papers:
Read the Editor in Chief's latest call for papers here.Submission types accepted:
Submissions of the following types of manuscripts are accepted:
- Original research articles.
- Reviews: comprehensive, authoritative, descriptions of any subject within the journal's scope. They may cover basic science and clinical reviews, ethics, pro/con debates, and equipment reviews.
- Commentaries: focused and opinionated articles on any subject within the journal's scope. These articles are usually related to a contemporary issue.
- Hypotheses: articles that present an original hypothesis backed solely by previously published results rather than any new evidence. They should outline significant progress in thinking that would also be testable.
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- Methodology articles: these discuss a new experimental method, test or procedure. The article must describe a demonstrable advance on what is currently available. The method needs to have been well tested and ideally, but not necessarily, used in a way that proves its value.
- Short reports: brief reports of data from original research.
- Meeting reports: a report pertaining to activity at a meeting or conference Articles published in this journal are immediately available without delay upon publication and enjoy substantial visibility.
All submissions are subject to prompt, objective and fair peer review in compliance with our Fairness in Peer Review Policy. Copyright in published articles remains with the author(s). Authors are continually informed of the progress of their paper and our staff are friendly and responsive.
One author recently wrote: "I would like to say that this is the most author-friendly editing process I have experienced in over 150 publications. Thank you most sincerely."
Criteria for publication:
Publication is dependent on peer reviewers' judgement of papers. Reviewers are asked to provide thoughtful and unbiased feedback to authors to ensure that the conclusions of papers are valid and manuscripts achieve reasonable standards of scholarliness and intelligibility.
Previous work in the field must be acknowledged and papers should read without unreasonable difficulty. Papers should fit comfortably within the scope of the journal.
Reviewers are asked to act in a fair, objective and constructive manner which maintains quality standards and helps authors to communicate their research. They are instructed that in areas of genuinely novel research issues may be raised which cannot immediately be resolved and that absolutely rigorous validation of data may therefore not be possible.
More information on the role of peer reviewers is available on the information for reviewers page. Where authors consider that reviewers have made recommendations which are unreasonable, unobjective or ill-founded they may appeal them to the Editor in Chief or Associate Editor under our Fairness in Peer Review Policy.
Articles submitted to other journals:
We are willing to consider papers which have been peer reviewed by other journals but not accepted for publication.
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- Provide bound reprints of your article in colour or black and white ,
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Full fee waivers are available for authors working in undeveloped nations and partial discounts of 20-50% are available to authors in other nations. Authors must be able to verifiably demonstrate their suitability for a discount or waiver. Availability of waivers and discounts is subject to monthly availability and is given at the publisher's discretion. Waivers and discounts must be applied for prior to submission. Neither are available after submission.
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Applicants must be able to demonstrate at least five years of continuous experience in the journal's subject area including at least two in the previous 24 months.
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Biomarker Insights is now indexed by Pubmed
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The journal has been accepted for indexing in EBSCO Academic Search Complete.
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Sample Stability and Protein Composition of Saliva: Implications for Its Use as a Diagnostic Fluid
Diederik Esser, Gloria Alvarez-Llamas, Marcel P. de Vries, Desiree Weening, Roel J. Vonk and Han Roelofsen.
Center for Medical Biomics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Abstract: Saliva is an easy accessible plasma ultra-filtrate. Therefore, saliva can be an attractive alternative to blood for measurement of diagnostic protein markers. Our aim was to determine stability and protein composition of saliva. Protein stability at room temperature was examined by incubating fresh whole saliva with and without inhibitors of proteases and bacterial metabolism followed by Surface Enhanced Laser Desorption/Ionization (SELDI) analyses. Protein composition was determined by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) fractionation of saliva proteins followed by digestion of excised bands and identification by liquid chromatography tandem mass spectrometry (LC-MS/MS). Results show that rapid protein degradation occurs within 30 minutes after sample collection. Degradation starts already during collection. Protease inhibitors partly prevented degradation while inhibition of bacterial metabolism did not affect degradation. Three stable degradation products of 2937 Da, 3370 Da and 4132 Da were discovered which can be used as markers to monitor sample quality. Saliva proteome analyses revealed 218 proteins of which 84 can also be found in blood plasma. Based on a comparison with seven other proteomics studies on whole saliva we identified 83 new saliva proteins. We conclude that saliva is a promising diagnostic fl uid when precautions are taken towards protein breakdown.
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