Home| About us| Widget| login/register| For authors| For reviewers |Submit a paper
(close)

(Ctrl-click to select multiple journals)


How should we address you?

Your email address


 Yes, sign up now
 Sign up for general news too

Privacy Statement
 
 
 

Biomarker Insights

Synopsis: An open access, peer reviewed electronic journal that covers all aspects of biomarker research and clinical applications.


Indexing: Pubmed, Pubmed Central, EBSCO Academic Research Complete, Embase, Embiology, SCOPUS, Google Scholar, CAS, DOAJ, OAIster.


Processing time: Decision in 2 weeks for 90% of papers.

Visibility: Most popular article read 1400+ times.

RSS

NEWS

TWITTER
View factor
for journal
159274


About this journal

ISSN: 1177-2719



Aims and scope:

Biomarker Insights is a peer-reviewed, open-access research journal where those engaged in biomarker research can turn for rapid communication of the latest advances in the application of biomarkers toward the discovery of new knowledge, and toward the clinical translation of that knowledge to increase the efficacy of practicing clinicians. Papers submitted for review in Biomarker Insights should focus on the following areas:

  • Biomarkers as tools in decision making
  • Regulatory acceptance of biomarkers
  • Biomarker development and validation
  • Role of collaborations and consortia in biomarker advancement
  • The "Economics" Behind Personalized Medicine and Pharmacogenomics
  • Toxicity biomarkers, toxicogenomics
  • Biomarkers for early efficacy assessment
  • Genetic biomarkers; genomic biomarkers
  • Protein biomarkers
  • Metabolomic biomarkers
  • Pathway analysis
  • Biomarkers in clinical pharmacology
  • Biomarkers for clinical safety assessment
  • Clinical pharmacogenomics
  • Biomarkers to monitor and predict disease progression and response to therapy
  • Clinical validation of biomarkers
  • Patient selection
  • Biomarkers as surrogate end-points
  • Biomarkers as indications for drug therapy
  • Biomarker assay development and validation
  • Outcome diagnostics
  • Cancer diagnostics
  • Monitoring response to therapy
  • Discovery-to-Diagnostic translation
  • Clinical Proteomics: potential of proteomic technologies in diagnostics
  • Expression signatures as diagnostic/prognostic tools
  • Imaging biomarkers pharmacodiagnostics, companion diagnostics
  • Integration of biomarkers into clinical practice guidelines and clinical decision support systems
  • Integration of biomarkers into mathematical models and algorithms

Editorial standards and procedures:

Submissions, excluding editorials, letters to the editor and dedications, will be peer reviewed by two reviewers.  Reviewers are required to provide fair, balanced and constructive reports.  

Under our Fairness in Peer Review Policy authors may appeal against reviewers' recommendations which are ill-founded, unobjective or unfair.  Appeals are considered by the Editor in Chief or Associate Editor.

Papers are not sent to peer reviewers following submission of a revised manuscript. Editorial decisions on re-submitted papers are based on the author's response to the initial peer review report.

Indexing:

This journal is indexed by the following services:

  • Pubmed
  • Pubmed Central
  • EBSCO Academic Research Complete
  • Embase
  • Embiology
  • SCOPUS
  • Google Scholar
  • CAS
  • DOAJ
  • OAIster

SPARC Europe Seal award winner:

This journal has been awarded a SPARC Europe Seal. The Seal is an initiative of SPARC Europe (Scholarly Publishing and Academic Resources Coalition) and the Directory of Open Access Journals (DOAJ) which is awarded to journals applying a Creative Commons CC-BY copyright license and that make journal metadata accessible to DOAJ.  

 Amongst other important services DOAJ makes metadata OAI-compliant.  This in turn enhances the visibility of papers and allows OAI-harvesters to include the details of journal articles in their services. We encourage readers to make use of this valuable resource.  The DOAJ search page is available here.

National Institutes of Health Public Access Policy compliant:

As of April 7 2008, the US NIH Public Access Policy requires that all peer reviewed articles resulting from research carried out with NIH funding be deposited in the Pubmed Central archive.

If you are an NIH employee or grantee Libertas Academica will ensure that you comply with the policy by depositing your paper at Pubmed Central on your behalf. 



 
 
 


Excision Repair Cross-Complementation Group 1 Enzyme as a Molecular Determinant of Responsiveness to Platinum-Based Chemotherapy for non Small-Cell Lung Cancer

Authors: Giannis Mountzios, Meletios-Athanasios Dimopoulos and Christos Papadimitriou
Publication Date: 17 Apr 2008
Biomarker Insights 2008:3 219-226

Giannis Mountzios, Meletios-Athanasios Dimopoulos and Christos Papadimitriou

Medical Oncology Unit, Department of Clinical Therapeutics, University Hospital Alexandra, Athens, Greece.

Abstract

Although platinum-based chemotherapy remains the “standard” in advanced non small-cell lung cancer, not all patients derive clinical benefit from such a treatment. Hence, the development of predictive biomarkers able to identify lung cancer patients who are most likely to benefit from cisplatin-based chemotherapy has become a scientific priority. Among the molecular pathways involved in DNA damage control after chemotherapy, the nucleotide excision repair (NER) is a critical process for the repair of DNA damage caused by cisplatin-induced DNA adducts. Many reports have explored the role of the excision repair cross-complementation group 1 enzyme (ERCC1) expression in the repair mechanism of cisplatin-induced DNA adducts in cancer cells.

Using immunohistochemistry in resected tumors from patients included in the International Adjuvant Lung Cancer Trial, the study of important biomarkers showed that high ERCC1 protein expression was associated with improved survival in chemo-naïve patients. On the contrary, the benefit of adjuvant cisplatin-based chemotherapy was more profound in patients with low ERCC1 expression. In a prospective cohort studying mRNA expression in tumor biopsies from patients receiving customized therapy with cisplatin and gemcitabine depending on the molecular profile of the tumour, results showed that patients with low ERCC1 mRNA expression had a longer median survival compared to those with high expression. These data suggest the potent use of ERCC1 as a molecular predictor of clinical resistance to platinum-based chemotherapy in the adjuvant setting of NSCLC. Nevertheless, optimization of methodology, including standardization of technical procedures, as well as validation of ERCC1 protein expression in large prospective cohorts, seem necessary before any routine immunohistochemical validation of ERCC1 can be implemented in daily practice.

Categories: Cancer , Biomarkers


Post comment




No comments yet...Be the first to comment.

Bookmark this article

LINKEDIN FACEBOOK

Add to Mixx! MIXX YAHOO! BUZZ

PERMALINK DIGG


Sign up for free journal updates

How should we address you?
Your email address
 Yes, sign up now


Recently published in this journal

Novel Biomarkers for the Diagnosis of Urinary Tract Infection - A Systematic Review
- 05/Aug/2009

Joint Variable Selection and Classification with Immunohistochemical Data
- 22/Jul/2009

Angiotensin II Type 1 Receptor Blockers Reduce Urinary Angiotensinogen Excretion and the Levels of Urinary Markers of Oxidative Stress and Inflammation in Patients with Type 2 Diabetic Nephropathy
- 23/Jun/2009

Pathway Analysis of Differentially Expressed Genes in Patients with Acute Aortic Dissection
- 06/May/2009

Investigating Multi-cancer Biomarkers and Their Cross-predictability in the Expression Profiles of Multiple Cancer Types
- 01/May/2009

Plasma Carotenoids and Biomarkers of Oxidative Stress in Patients with prior Head and Neck Cancer
- 23/Mar/2009

Low Serum Alpha-1 Antitrypsin (AAT) in Family Members of Individuals with Autism Correlates with PiMZ Genotype
- 18/Mar/2009

Cartilage Oligomeric Matrix Protein (COMP): A Biomarker of Arthritis
- 17/Feb/2009

Breath Hydrogen Produced by Ingestion of Commercial Hydrogen Water and Milk
- 09/Feb/2009

Effects of Cyclooxygenase Inhibitors on Apoptotic Neuroretinal Cells
- 08/Jul/2008

Changes in plasma IL-6, plasma VEGF and serum YKL-40 during Treatment with Etanercept and Methotrexate or Etanercept alone in Patients with Active Rheumatoid Arthritis Despite Methotrexate Therapy (Provisional PDF)
- 15/Jan/2009

Breath Hydrogen Gas Concentration Linked to Intestinal Gas Distribution and Malabsorption in Patients with Small-bowel Pseudo-obstruction
- 15/Jan/2009

Gene Expression in Hair Follicle Dermal Papilla Cells after Treatment with Stanozolol
- 23/Dec/2008

Biomarkers in Acute Coronary Syndrome
- 05/Nov/2008

Radionuclide-Based Cancer Imaging Targeting the Carcinoembryonic Antigen
- 23/Sep/2008

Clinical Performance of a Salivary Amylase Activity Monitor During Hemodialysis Treatment
- 15/Sep/2008

Hematopoietic Lineage Transcriptome Stability and Representation in PAXgeneTM Collected Peripheral Blood Utilising SPIA Single-Stranded cDNA Probes for Microarray
- 25/Aug/2008

Pulmonary Biomarkers of Bronchopulmonary Dysplasia
- 02/Jul/2008

Detection of Colorectal Cancer by Serum and Tissue Protein Profiling: A Prospective Study in a Population at Risk
- 02/Jul/2008

Tracking Differential Gene Expression in MRL/MpJ Versus C57BL/6 Anergic B Cells: Molecular Markers of Autoimmunity
- 10/Jun/2008

Proteomics Discovery of Disease Biomarkers
- 06/Jun/2008

Activation of Tissue Remodeling Precedes Obliterative Bronchiolitis in Lung Transplant Recipients
- 06/Jun/2008

Alzheimer’s Disease, Diagnosis and the Need for Biomarkers
- 27/May/2008

Serum Concentrations of F2-Isoprostanes and 4-Hydroxynonenal in Hemodialysis Patients in Relation to Inflammation and Renal Anemia
- 27/May/2008

Biomarkers and Bioassays for Cardiovascular Diseases: Present and Future
- 19/May/2008

MUC1 as a Putative Prognostic Marker for Prostate Cancer
- 14/May/2008

Changes in Hyaluronan Metabolism and RHAMM Receptor Expression Accompany Formation of Complicated Carotid Lesions and May be Pro-Angiogenic Mediators of Intimal Neovessel Growth
- 12/May/2008

What is New on Thyroid Cancer Biomarkers
- 29/Apr/2008

DICER1 and PRKRA in Colon Adenocarcinoma
- 28/Apr/2008

A Rapid and Simple Bioassay Method for Herbicide Detection
- 28/Apr/2008

Dendritic Cells Promoted by Ginseng Saponins Drive a Potent Th1 Polarization
- 18/Apr/2008

Comparison of the Calibration Standards of Three Commercially Available Multiplex Kits for Human Cytokine Measurement to WHO Standards Reveals Striking Differences
- 18/Apr/2008

Excision Repair Cross-Complementation Group 1 Enzyme as a Molecular Determinant of Responsiveness to Platinum-Based Chemotherapy for non Small-Cell Lung Cancer
- 17/Apr/2008

Biomarkers of Ovarian Reserve
- 16/Apr/2008

Novel Biomarkers Associated with Deep Venous Thrombosis: A Comprehensive Review
- 10/Apr/2008

The Role of Thrombospondin 1 on Intestinal Inflammation and Carcinogenesis
- 28/Mar/2008

Time Dependent Gene Expression Changes in the Liver of Mice Treated with Benzene
- 28/Mar/2008

Chemical Biomarkers of Human Breast Milk Pollution
- 28/Mar/2008

Useulness of B Natriuretic Peptides and Procalcitonin in Emergency Medicine
- 27/Mar/2008

FTIR Microspectroscopy Coupled with Two-Class Discrimination Segregates Markers Responsible for Inter- and Intra-Category Variance in Exfoliative Cervical Cytology
- 25/Mar/2008

Serum and Ascitic Fluid Superoxide Dismutase and Malondialdehyde Levels in Patients with Cirrhosis
- 12/Mar/2008

Circulating Markers Reflect Both Anti- and Pro-Atherogenic Drug Effects in ApoE-Deficient Mice
- 12/Mar/2008

Proteomic Biomarkers of Atherosclerosis
- 12/Mar/2008

An Evaluation of the Clinical Evidence on the Role of Inflammation and Oxidative Stress in Smoking-Mediated Cardiovascular Disease
- 01/Mar/2008

Repeatedly Heading a Soccer Ball Does Not Increase Serum Levels of S-100B, a Biochemical Marker of Brain Tissue Damage: an Experimental Study
- 29/Feb/2008

Biomarkers in Acute Kidney Injury
- 26/Feb/2008

Cellular Adhesion Molecules in Healthy Subjects: Short Term Variations and Relations to Flow Mediated Dilation
- 14/Feb/2008

Expression of Osteoarthritis Marker YKL-39 is Stimulated by Transforming Growth Factor Beta (TGF-beta) and IL-4 in Differentiating Macrophages
- 14/Feb/2008

Genomic and Proteomic Biomarker Discovery in Neurological Disease
- 09/Feb/2008

Candidate List of yoUr Biomarker (CLUB): A Web-based Platform to Aid Cancer Biomarker Research
- 09/Feb/2008

Sample Stability and Protein Composition of Saliva: Implications for Its Use as a Diagnostic Fluid
- 01/Feb/2008

Elevated CAIX Expression is Associated with an Increased Risk of Distant Failure in Early-Stage Cervical Cancer
- 01/Feb/2008

Marker of Bone Resorption in Acute Response to Exogenous or Endogenous Parathyroid Hormone
- 25/Jan/2008

DNA Methylation in Circulating Tumour DNA as a Biomarker for Cancer
- 25/Jan/2008

Antibody Arrays Identify Potential Diagnostic Markers of Hepatocellular Carcinoma
- 21/Jan/2008

Increased Intrathecal Chemokine Receptor CCR2 Expression in Multiple Sclerosis
- 18/Dec/2007

Using LongSAGE to Detect Biomarkers of Cervical Cancer Potentially Amenable to Optical Contrast Agent Labelling
- 11/Dec/2007

Clastogenic Factors as Potential Biomarkers of Increased Superoxide Production
- 11/Dec/2007

An EGFR and AKT Signaling Pathway was Identified with Mediation Model in Osteosarcomas Clinical Study
- 11/Dec/2007

Genetic Alterations in Pesticide Exposed Bolivian Farmers: An evaluation by analysis of chromosomal aberrations and the comet assay
- 12/Nov/2007

Prognostic Significance of in situ Phenotypic Marker Expression in Diffuse Large B-cell Lymphomas
- 11/Nov/2007

The Role of Structural Extracellular Matrix Proteins in Urothelial Bladder Cancer
- 05/Nov/2007

Validation of Candidate Serum Ovarian Cancer Biomarkers for Early Detection
- 16/Oct/2007

Endogenous Plasma Peptide Detection and Identification in the Rat by a Combination of Fractionation Methods and Mass Spectrometry
- 09/Oct/2007

Induction of Proteases in Peritoneal Carcinomatosis, the Role of ICAM-1/CD43 Interaction
- 08/Oct/2007

Recursive Partitioning Analysis of Mediastinal N2 Lymph Node Involvement with Selected Biological Markers in Operable Non-small Cell Lung Cancer: A Correlative Study
- 06/Oct/2007

Proteomics and Mass Spectrometry for Cancer Biomarker Discovery
- 03/Oct/2007

Endogenous Secretory RAGE as a Novel Biomarker for Metabolic Syndrome and Cardiovascular Diseases
- 17/Sep/2007

Electron Pathways through Erythrocyte Plasma Membrane in Human Physiology and Pathology: Potential Redox Biomarker?
- 17/Sep/2007

Genome-Wide Association Studies: Progress in Identifying Genetic Biomarkers in Common, Complex Diseases
- 08/Aug/2007

Studies of Wilms’ Tumor (WT1) Gene Expression in Adult Acute Leukemias in Singapore
- 08/Aug/2007

Alteration of Transthyretin Microheterogeneity in Serum of Multiple Trauma Patients
- 08/Aug/2007

Determination of Tobacco Specific Hemoglobin Adducts in Smoking Mothers and New Born Babies by Mass Spectrometry
- 06/Aug/2007

Soluble CD26 is inversely Associated with Disease Severity in Patients with Chronic Eosinophilic Pneumonia
- 07/Feb/2007

Multianalyte Tests for the Early Detection of Cancer: Speedbumps and Barriers
- 10/Jul/2007

Biomarker Discovery in Animal Health and Disease: The Application of Post-Genomic Technologies
- 10/Jul/2007

Gene Expression Profiles from Needle Biopsies Provide Useful Signatures of Non-Small Cell Lung Carcinomas
- 08/Jun/2007

Mouse Germ Cell Development in-vivo and in-vitro
- 06/Jun/2007

Protein Tyrosine Phosphatase Gamma (PTPγ) is a Novel Leukocyte Marker Highly Expressed by CD34+ Precursors
- 31/May/2007

TLR2 and TLR4 as Potential Biomarkers of Environmental Particulate Matter Exposed Human Myeloid Dendritic Cells
- 30/May/2007

Expression of Cancer-Associated Molecules in Malignant Mesothelioma
- 30/May/2007

Molecular Markers for Biomass Traits: Association, Interaction and Genetic Divergence in Silkworm Bombyx mori
- 30/May/2007

The Clinical Application of Anti-CCP in Rheumatoid Arthritis and Other Rheumatic Diseases
- 03/May/2007

Human Chitinases and Chitinase-Like Proteins as Indicators for Inflammation and Cancer
- 03/May/2007

Ubiquitin Fusion Degradation Protein 1 as a Blood Marker for The Early Diagnosis of Ischemic Stroke
- 19/Apr/2007

Evaluation of Tissue Metabolites with High Resolution Magic Angle Spinning MR Spectroscopy Human Prostate Samples After Three-Year Storage at -80 ºC
- 18/Apr/2007

The Sample Type used Affects the Levels of Gelatinases (MMP-2 and -9) and their Inhibitors (TIMP-1 and -2) in Circulating Blood of Healthy Controls and Breast Cancer Patients
- 03/Apr/2007

Changes in Metallothionein Levels in Freshwater Mussels Exposed to Urban Wastewaters: Effects from Exposure to Heavy Metals?
- 29/Mar/2007

Biomarkers in Bladder Cancer: Present Status and Perspectives
- 27/Mar/2007

Pharmacodynamic Effects of an Angiotensin II Receptor-Antagonist in Phase I: Comparison between Healthy Subjects and Patients with Hypertension
- 22/Mar/2007

BRCA1 Expression is an Important Biomarker for Chemosensitivity: Suppression of BRCA1 Increases the Apoptosis via Up-regulation of p53 and p21 During Cisplatin Treatment in Ovarian Cancer Cells
- 02/Mar/2007

Clinical Significance of Telomere Length and Associated Proteins in Oral Cancer
- 14/Feb/2007

Methodology and Applications of Disease Biomarker Identification in Human Serum
- 14/Feb/2007

Negative Regulation of Receptor Tyrosine Kinase (RTK) Signaling: A Developing Field
- 14/Feb/2007

Microvessel Density and Clinicopathologic Characteristics in Hepatocellular Carcinoma With and Without Cirrhosis
- 14/Feb/2007

Leukemia Associated Antigens: Their Dual Role as Biomarkers and Immunotherapeutic Targets for Acute Myeloid Leukemia
- 14/Feb/2007

Evaluation of Cellular Fibronectin Plasma Levels as a Useful Staging Tool in Different Stages of Transitional Cell Carcinoma of the Bladder and Renal Cell Carcinoma
- 07/Feb/2007

Biomarkers in Cervical Cancer
- 07/Feb/2007

Ceruloplasmin (2-D PAGE) Pattern and Copper Content in Serum and Brain of Alzheimer Disease Patients
- 07/Feb/2007

Comparison of Apoptosis Detection Markers Combined with Macrophage Immunostaining to Study Phagocytosis of Apoptotic Cells in Situ
- 07/Feb/2007



Related journals...