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Biomarker Insights

Synopsis: An open access, peer reviewed electronic journal that covers all aspects of biomarker research and clinical applications.


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About this journal

ISSN: 1177-2719



Aims and scope:

Biomarker Insights is a peer-reviewed, open-access research journal where those engaged in biomarker research can turn for rapid communication of the latest advances in the application of biomarkers toward the discovery of new knowledge, and toward the clinical translation of that knowledge to increase the efficacy of practicing clinicians. Papers submitted for review in Biomarker Insights should focus on the following areas:

  • Biomarkers as tools in decision making
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  • Biomarker development and validation
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  • The "Economics" Behind Personalized Medicine and Pharmacogenomics
  • Toxicity biomarkers, toxicogenomics
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  • Clinical pharmacogenomics
  • Biomarkers to monitor and predict disease progression and response to therapy
  • Clinical validation of biomarkers
  • Patient selection
  • Biomarkers as surrogate end-points
  • Biomarkers as indications for drug therapy
  • Biomarker assay development and validation
  • Outcome diagnostics
  • Cancer diagnostics
  • Monitoring response to therapy
  • Discovery-to-Diagnostic translation
  • Clinical Proteomics: potential of proteomic technologies in diagnostics
  • Expression signatures as diagnostic/prognostic tools
  • Imaging biomarkers pharmacodiagnostics, companion diagnostics
  • Integration of biomarkers into clinical practice guidelines and clinical decision support systems
  • Integration of biomarkers into mathematical models and algorithms

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Submissions, excluding editorials, letters to the editor and dedications, will be peer reviewed by two reviewers.  Reviewers are required to provide fair, balanced and constructive reports.  

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Proteomics Discovery of Disease Biomarkers

Authors: Mamoun Ahram and Emanuel F. Petricoin
Publication Date: 06 Jun 2008
Biomarker Insights 2008:3 325-333

Mamoun Ahram1 and Emanuel F. Petricoin2

1Department of Pharmacology and Physiology, Faculty of Medicine, Mutah University, Mutah, Jordan. 2Center for Applied Proteomics and Molecular Medicine, George Mason University, Virginia, U.S.A.

Abstract

Recent technological developments in proteomics have shown promising initiatives in identifying novel biomarkers of various diseases. Such technologies are capable of investigating multiple samples and generating large amount of data end-points. Examples of two promising proteomics technologies are mass spectrometry, including an instrument based on surface enhanced laser desorption/ionization, and protein microarrays. Proteomics data must, however, undergo analytical processing using bioinformatics. Due to limitations in proteomics tools including shortcomings in bioinformatics analysis, predictive bioinformatics can be utilized as an alternative strategy prior to performing elaborate, high-throughput proteomics procedures. This review describes mass spectrometry, protein microarrays, and bioinformatics and their roles in biomarker discovery, and highlights the significance of integration between proteomics and bioinformatics.

Categories: Biomarkers , Proteomics


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