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Biomarker Insights

Synopsis: An open access, peer reviewed electronic journal that covers all aspects of biomarker research and clinical applications.


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About this journal

ISSN: 1177-2719



Aims and scope:

Biomarker Insights is a peer-reviewed, open-access research journal where those engaged in biomarker research can turn for rapid communication of the latest advances in the application of biomarkers toward the discovery of new knowledge, and toward the clinical translation of that knowledge to increase the efficacy of practicing clinicians. Papers submitted for review in Biomarker Insights should focus on the following areas:

  • Biomarkers as tools in decision making
  • Regulatory acceptance of biomarkers
  • Biomarker development and validation
  • Role of collaborations and consortia in biomarker advancement
  • The "Economics" Behind Personalized Medicine and Pharmacogenomics
  • Toxicity biomarkers, toxicogenomics
  • Biomarkers for early efficacy assessment
  • Genetic biomarkers; genomic biomarkers
  • Protein biomarkers
  • Metabolomic biomarkers
  • Pathway analysis
  • Biomarkers in clinical pharmacology
  • Biomarkers for clinical safety assessment
  • Clinical pharmacogenomics
  • Biomarkers to monitor and predict disease progression and response to therapy
  • Clinical validation of biomarkers
  • Patient selection
  • Biomarkers as surrogate end-points
  • Biomarkers as indications for drug therapy
  • Biomarker assay development and validation
  • Outcome diagnostics
  • Cancer diagnostics
  • Monitoring response to therapy
  • Discovery-to-Diagnostic translation
  • Clinical Proteomics: potential of proteomic technologies in diagnostics
  • Expression signatures as diagnostic/prognostic tools
  • Imaging biomarkers pharmacodiagnostics, companion diagnostics
  • Integration of biomarkers into clinical practice guidelines and clinical decision support systems
  • Integration of biomarkers into mathematical models and algorithms

Editorial standards and procedures:

Submissions, excluding editorials, letters to the editor and dedications, will be peer reviewed by two reviewers.  Reviewers are required to provide fair, balanced and constructive reports.  

Under our Fairness in Peer Review Policy authors may appeal against reviewers' recommendations which are ill-founded, unobjective or unfair.  Appeals are considered by the Editor in Chief or Associate Editor.

Papers are not sent to peer reviewers following submission of a revised manuscript. Editorial decisions on re-submitted papers are based on the author's response to the initial peer review report.

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This journal is indexed by the following services:

  • Pubmed
  • Pubmed Central
  • EBSCO Academic Research Complete
  • Embase
  • Embiology
  • SCOPUS
  • Google Scholar
  • CAS
  • DOAJ
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SPARC Europe Seal award winner:

This journal has been awarded a SPARC Europe Seal. The Seal is an initiative of SPARC Europe (Scholarly Publishing and Academic Resources Coalition) and the Directory of Open Access Journals (DOAJ) which is awarded to journals applying a Creative Commons CC-BY copyright license and that make journal metadata accessible to DOAJ.  

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As of April 7 2008, the US NIH Public Access Policy requires that all peer reviewed articles resulting from research carried out with NIH funding be deposited in the Pubmed Central archive.

If you are an NIH employee or grantee Libertas Academica will ensure that you comply with the policy by depositing your paper at Pubmed Central on your behalf. 



 
 
 


Clinical Performance of a Salivary Amylase Activity Monitor During Hemodialysis Treatment

Authors: Masaru Shimazaki, Takayuki Matsuki, Kazuaki Yamauchi, Michihiro Iwata, Hiroshi Takahashi, Kenichi Sakamoto, Junichi Ohata, Yuichi Nakamura and Yusuke Okazaki
Publication Date: 15 Sep 2008
Biomarker Insights 2008:3 429-434

Masaru Shimazaki1, Takayuki Matsuki2, Kazuaki Yamauchi3, Michihiro Iwata2, Hiroshi Takahashi2, Kenichi Sakamoto2, Junichi Ohata2, Yuichi Nakamura2 and Yusuke Okazaki3

1Division of Hemodialysis, Shin-Nittetsu Muroran General Hospital, Muroran, Japan. 2Department of Cardiology, Shin-Nittetsu Muroran General Hospital, Muroran, Japan. 3Department of Internal Medicine, Shin-Nittetsu Muroran General Hospital, Muroran, Japan.

Abstract

The hemodialysis procedure is thought to be a physical stressor in the majority of hemodialyzed patients. Previous studies suggest that elevated salivary amylase level may correlate with increased plasma norepinephrine level under psychological and physical stress conditions. In this study, we investigated biological stress reactivity during hemodialysis treatment using salivary amylase activity as a biomarker. Seven patients (male/female =  5/2, age:67.7+ /− 5.9 years) who had been receiving regular 4 h hemodialysis were recruited. Salivary amylase activity was measured using a portable analyzer every hour during the hemodialysis session. Salivary amylase activity was shown to be relatively stable and constant throughout hemodialysis, whereas there were significant changes in systolic blood pressure and pulse rate associated with blood volume reduction. Our results show that hemodialysis treatment per se dose not affect salivary amylase activity.

Categories: Biomarkers


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