Immunology
Open access articles on immunology. Articles from Immunology and Immunogenetics Insights, Immunotherapy Insights.
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- Evaluation of Knowledge, Attitude and Performance of the Mothers of Children Affected by Cutaneous Leishmaniasis
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Immunology and Immunogenetics Insights
Relationship Between Celiac Disease Markers and Gastrointestinal Disease in Children with Autism (19/Mar/2010)
Aim: This study was designed to determine if there is a relationship between celiac disease (CD) and the presence of gastrointestinal disease (GI) disease in children with autism. Subjects and Methods: One hundred twenty-two children were tested for IgG and IgA anti-transglutaminase autoantibodies (55 autistic children with GI disease, 28 non...
Generalized Autoimmunity of ANCA and ASCA Related to Severity of Disease in Autistic Children with GI Disease (08/Oct/2009)
Aim: To assess serum Anti-Neutrophil cytoplasmic Antibody (ANCA—PR3 and MPO) and Anti-Saccharomyces Cerevisiæ Antibody (ASCA) levels in autistic children with severe gastrointestinal (GI) disease and to test the hypothesis that there is generalized autoimmunity in a subpopulation of autistic children with severe GI disease and that this autoimmunity is associated...
Dose-Specific Biphasic Effects of Simvastatin on the Expression of CXCL10 and CX3CL1 by Human Osteoblasts (17/Aug/2009)
Objective: To better understand the effects of simvastatin (SS) on the expression and secretion of two chemokines, CXCL10 and CX3CL1, by osteoblasts, and to test whether inhibition of isoprenoid intermediates of cholesterol biosynthesis were involved in the effects of SS. Methods: Human osteoblasts were incubated in the presence or absence of...
Aim: To assess both ant-PR3 and anti-MPO IgG anti-neutrophil cytoplasmic antibodies (ANCA), in autistic children with gastrointestinal symptoms and controls, and to test the hypothesis that there is an association between the presence of these antibodies and inflammatory GI disease seen in many autistic children. Subjects and Methods: ELISA’s were used...
Characteristics of Activated Monocyte Phenotype Support R5-Tropic Human Immunodeficiency Virus (10/Mar/2009)
Background: Microbial translocation has been recognized as an important factor in monocyte activation and contributing to AIDS pathogenesis with elevated plasma lipopolysaccharide (LPS) levels, as a marker for microbial translocation, seen in advanced HIV disease. Therefore, the current study was undertaken to assess monocyte activation in vitro by LPS...
Is the Adipose Tissue the Key Road to Inflammation? (17/Feb/2009)
It is now broadly accepted that white adipose tissue disorders, such as obesity, are associated with a chronic low-grade inflammation predisposing to the development of insulin-resistance, type 2 diabetes and cardiovascular complications. In obesity, accumulation of visceral adipose tissue, rather than subcutaneous adipose tissue, is regarded as the most critical...
Introductory Editorial by Dr Darren R Flower, The Jenner Institute, University of Oxford, Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Headley Way, Headington, Oxford, U.K.
Immunotherapy Insights
Epstein-Barr virus (EBV)-associated malignancies offer a unique model to develop T cell-based immune therapies, targeting viral antigens expressed on tumor cells. Throughout the last 15 years, EBV-specific cytotoxic T-lymphocytes (CTL) have been successfully employed for the prophylaxis and treatment of EBV-related lymphoproliferative disorders (LPD) in immunocompromised hosts, particularly after hematopoietic...
Introductory Editorial (Immunotherapy Insights) (29/Jan/2009)
Introductory Editorial by Dr John Barrett, Allogeneic Stem Cell Transplantation, Bethesda, Maryland, U.S.A.