Pathology
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Journal: Clinical Medicine Insights: Pathology
Journal: Indian Journal of Clinical Medicine
Bilateral Basal Cell Adenocarcinoma of the Parotid Gland: In a Recipient of Kidney Transplant (18/Feb/2010)
We report a rare case of bilateral basal cell adenocarcinoma (BcAC) of the parotid gland in a male patient 30 years after kidney transplantation and continuous administration of immunosuppressive therapy. BcAC is a salivary gland malignancy first recognized as a distinct neoplastic entity in WHO classification of salivary gland tumours in 1991. Over 90% of BcACs are detected in the parotid gland. The most important differential diagnosis is basal cell adenoma. Infiltrative growth is the...
Immunohistochemistry as an Important Tool in Biomarkers Detection and Clinical Practice (09/Feb/2010)
The immunohistochemistry technique is used in the search for cell or tissue antigens that range from amino acids and proteins to infectious agents and specific cellular populations. The technique comprises two phases: (1) slides preparation and stages involved for the reaction; (2) interpretation and quantification of the obtained expression. Immunohistochemistry is an important tool for scientific research and also a complementary technique for the elucidation of differential diagnoses which are not determinable by conventional analysis...
Adenomatoid Tumor of Testis (09/Sep/2009)
Adenomatoid tumors are responsible for 30% of all paratesticular masses. These are usually asymptomatic, slow growing masses. They are benign tumors comprising of cords and tubules of cuboidal to columnar cells with vacuolated cytoplasm and fibrous stroma. They are considered to be of mesothelial origin supported by histochemical studies and...
Expression of Placental Neurotrophin-3 (NT-3) in Physiological Pregnancy, Preeclampsia and Chorioamnionitis (11/Jun/2009)
Neurotrophic factors are a group of proteins that act as paracrine and autocrine growth factors. They are involved in the regulation of morphogenesis and development of several tissues. The present study aims to evaluate, for the first time, the expression of Neurotrophin-3 in the human placenta during normal pregnancy and in preeclampsia and chorioamnionitis. Neurotrophin-3 mRNA, assessed by RT-PCR analysis in six term placentas, were observed in all the specimens examined. Neurotrophin-3 protein expression and...
Choroidal melanoma is the commonest adult primary intraocular tumour,1 and usual sites of secondary spread are to liver, bone and lung. Although delayed recurrence of ipsilateral orbital melanoma is well documented, metastasis to the contralateral orbit is a rarely encountered phenomenon. We describe a case of metastatic spread to the...
Krishna Pandey, Prabhat Kumar Sinha, Vidyanand Ravi Das, Sanjiva Bimal, Shubhankar K. Singh and Pradeep DasRajendra Memorial Research Institute of Medical Sciences (ICMR), Agamkuan, Patna-800 007, Bihar, India.Abstract Visceral leishmaniasis (VL) or Kala-azar is a protozoal disease, which was previously regarded as one of the most neglected tropical diseases. Management...
Pneumococcal Induced T-activation with Resultant Thrombotic Microangiopathy. A case report and overview (Provisional PDF) (08/Jan/2009)
J.W. Oliver, R.S. Akins, M.K. Bibens and D.M. DunnAbstractThrombotic microangiopathies are disorders resulting from platelet thromboses forming in the microvasculature with resultant schistocyte forms. Hemolytic uremic syndrome (HUS) is a microangiopathic hemolytic anemia often complicated by acute renal failure in children. HUS is typically caused by bacterial infection, most commonly...
Pathology-Dependent Histological Changes of the Left Stellate Ganglia: A Cadaveric Study (30/Oct/2008)
Salvatore Docimo, Jr.1,4, Carmen Piccolo2, Daniel Van Arsdale3 and David E. Elkowitz4 1Academic Medicine Fellow, Department of Pathology, New York College of Osteopathic Medicine, Old Westbury, NY. 2Resident, Department of Surgery, Philadelphia College of Osteopathic Medicine, Philadelphia, PA. 3Department of Osteopathic Manipulative Medicine, New York College of Osteopathic Medicine,...
The Pathogenesis of Autism (18/Sep/2008)
Timothy John Watts Barts and the London School of Medicine and Dentistry, Turner Street, London, E1 2AD, U.K. Abstract Autism is well known as a complex developmental disorder with a seemingly confusing and uncertain pathogenesis. The definitive mechanisms that promote autism are poorly understood and mostly unknown,...
Jay Patel1 and Lester J. Layfield2 1Resident in Department of Pathology, University of Utah School of Medicine and ARUP Laboratories, Salt Lake City, Utah. 2Professor and Head, Division of Anatomic Pathology, Department of Pathology, University of Utah School of Medicine and ARUP Laboratories, Salt Lake City, Utah. Abstract...
Successful Management of Multifactorial Colitis in a Recipient of Hematopoietic Stem Cell Transplant: A Case Report (29/Jul/2008)
Khalid A. Al-Anazi1, Asma M. Al-Jasser3, Amal Abdulwahab1, Entezam Sahovic1, Hadeel Almana2 and Mohammed A. Al Fadda2 1Section of Adult Hematology and Hematopoietic Stem Cell Transplant, King Faisal Cancer Centre, King Faisal Specialist Hospital and Research Centre, P.O. Box: 3354, Riyadh 11211, Saudi Arabia. 2Departments of Medicine and Pathology,...
Commonality Between Diabetes and Alzheimer’s Disease and A New Strategy for the Therapy (28/Jul/2008)
Li Lin Key laboratory of cellular physiology, Shanxi Medical University, China. Abstract A surprising common pathological processes is found between Alzheimer’s disease (AD) and type 2 diabetes mellitus (T2DM)[1]. AD and T2DM share some common pathological processes: Amyloid β (Aβ), τ hyperphosphoralation, insulin abnormality. Disturbance in insulin signalling is...
Lisbeth Birk Møller and Nina Horn Kennedy Center, Gl. Landevej 7, 2600 Glostrup, Denmark. Abstract Menkes disease (MD) is a rare recessively inherited lethal disorder of copper metabolism. The gene ATP7A defective in MD consists of 23 exons and the coding region encompasses 4500 bp. About 300...
DICER1 and PRKRA in Colon Adenocarcinoma (28/Apr/2008)
S. Chiosea, M. Acquafondata, J. Luo, SF. Kuan, RR. Seethala Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, U.S.A. Abstract Differential microRNA expression in colon adenocarcinoma (CA) was previously reported. MicroRNA biogenesis and function requires a set of proteins designated as the microRNA machinery, which...
Histological Changes on Liver Glycogen Storage in Mice (Mus musculus) Caused by Unbalanced Diets (23/Apr/2008)
Esma Ulusoy and Banu Eren Faculty of Arts and Science, Department of Biology, University of Ondokuz Mayıs, Samsun, Turkey. Abstract Weight-losing diets have appealed to people who want to lose weight in the short-term. They usually apply high-protein (HP) diets (like Atkin’s, Stillman’s, Scarsdale) which...
Vincent Ho1, Andrew Shearer2 and Mark Jagusch3 1Clinical Senior Lecturer, School of Medicine, James Cook University, Cairns, Queensland, Australia. 2Haematologist, Department of Medicine, Cairns Base Hospital, Cairns, Queensland, Australia. 3Head Department of Pathology, Cairns Base Hospital, Cairns, Queensland, Australia. AbstractPathological rupture of the spleen...
Mitchell S. Wachtel1, Yan Zhang2, Tom Xu2, Maurizio Chiriva-Internati3 and Eldo E Frezza4 1Department of Pathology. 2Department of Family Medicine. 3Department of Microbiology and Immunology. 4Department of Surgery, Texas Tech University Health Sciences Center. Abstract Aim: Combined hepatocellular cholangiocarcinoma (combined tumor) has been described...
P16/Ki-67 Immunostaining is Useful in Stratification of Atypical Metaplastic Epithelium of the Cervix (19/Mar/2008)
Ann E. Walts and Shikha Bose Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, California 90048. Abstract Cervical metaplastic squamous epithelium exhibiting atypia insufficient for a diagnosis of cervical intraepithelial neoplasia (CIN) is usually reported as “atypical squamous metaplasia” (ASM). Stratification impacts treatment since the...
Combination of Immunohistochemistry and Ploidy Analysis to Assist Histopathological Diagnosis of Molar Diseases (19/Mar/2008)
Osterheld M.C., Caron L., Chaubert P. and Meagher-Villemure K. Institut Universitaire de Pathologie Rue du Bugnon 25 1011 Lausanne-CHUV. Abstract Background: Differential diagnosis between hydropic abortion, partial mole and complete mole is still a challenge for pathologists but really important for patient management. Material and Method:...
Claudia-S.Vetter-Kauczok, Jürgen-C. Becker and Eva-B. Bröcker Klinik und Poliklinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum Würzburg, Josef-Schneider-Strasse 2, 97080 Würzburg, Germany.
Squamous Differentiation and Cytokeratin Expression in an Osteosarcoma: A Case Report and Review of the Literature (18/Mar/2008)
Lester J. Layfield1, Lyska Emerson1, Julia R. Crim2 and Lor Randall3 1Departments of Pathology. 2Radiology and 3Orthopedic Surgery (Sarcoma Service) University of Utah Hospital and Clinics, Salt Lake City, Utah, 84132. Abstract Cytokeratin expression has been documented in a variety of sarcomas including synovial sarcomas, epithelioid sarcomas,...
Kaei Nasu, Noriyuki Takai, Masakazu Nishida and Hisashi Narahara Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Oita, Japan. Abstract Tamoxifen is widely used for endocrine treatment and breast cancer prevention. It acts as both an estrogen antagonist in breast tissue and an estrogen agonist...
Cheng-Chiang Chang1, Shin-Tsu Chang1, Chih-Hung Ku2, Shang-Lin Chiang1, Hsiao-Ying Chang3, Min-Hsin Lai1, Kao-Chung Tsai1 and Liang-Cheng Chen1 1Department of Physical Medicine and Rehabilitation, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei, Taiwan. 2School of Public Health, National Defense Medical Center, Taipei. Taiwan. 3Department of Nursing,...