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Clinical Medicine: Oncology

Synopsis: An open access, peer reviewed electronic journal that covers cancer research and treatment.


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Clinical Medicine: Oncology is an international peer reviewed open access journal which publishes articles on all aspects of cancer research and treatment. Of particular interest are the following topics:
  • Molecular biology
  • Genetics
  • Pathophysiology
  • Epidemiology
  • Clinical interventions
  • Controlled trials
  • The diagnosis and treatment of patients with cancer
  • Therapeutics, pharmacology and drug delivery
  • Techniques of cancer surgery

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ISSN: 1177-9314


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Recent Advances in Proteomics and Cancer Biomarker Discovery

Authors: Gary Guishan Xiao, Robert R. Recker and Hong-Wen Deng
Publication Date: 09 Feb 2008
Clinical Medicine: Oncology 2008:2 63-72

Gary Guishan Xiao1, Robert R. Recker1 and Hong-Wen Deng2

1Osteoporosis Research Center, Departments of Medicine and Biomedical Sciences, Creighton University, 601 N 30th ST, Suite 6730, Omaha, NE 68131; 2Departments of Orthopedic Surgery and Basic Medical Sciences, University of Missouri—Kansas City, 2411 Holmes Street. Room M3-C03, City, Missouri, 64108-2792.

Abstract

Early diagnosis and prevention is a key factor in reducing the mortality and morbidity of cancer. However, currently available screening tools lack enough sensitivity for early diagnosis. It is important to develop non-invasive techniques and methods that can screen and identify asymptomatic patients who have cancer. Biomarkers of cancer status can also serve as powerful tools in monitoring the course of cancer and in determining the efficacy and safety of novel therapies. Thus, discovery of novel specific biomarkers are needed that may provide informative clues for early diagnosis and treatment of cancer. Recently, remarkable progress has been made in the development of new proteomics technology. The progress that has been made in this field is helpful in identifying biomarkers that can be used for early diagnosis of cancer and improving the understanding of the molecular etiological mechanism of cancer. This article describes the current state of the art in this field.

Categories: Cancer , Genomics , Oncology , Biomarkers


Post comment




Posted by
CS Cho, Ph.D.
12:42,August 02, 2008

In addition to the reference on serum amyloid A on nasopharyngeal carcinoma for the diagnosis, there is a report on its potentially use as a biomarker to monitor relapse of NPC by serum proteomic profiling (Cho WC, et al., Clin Cancer Res. 2004;10:43-52.). Thanks for your kind attention.

Posted by
Dr. Deng, MD
22:24,March 16, 2008

The novel method (mSILAC) is very interesting and could be powerful approach to biomarker discovery!


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