The Presence of Precursors of Benign Pre-B Lymphoblasts (Hematogones) in the Bone Marrow of a Paediatric Patient with Cytomegalovirus Infection
Moreno-Madrid F1, Uberos J2, Díaz-Molina M1, Ramírez-Arredondo A1, Jiménez-Gámiz P3 and Molina-Carballo A2
1Servicio de Pediatría; Ciudad Sanitaria Virgen de las Nieves. 2Distrito Sanitario Granada. 3Servicio de Hematología; Ciudad Sanitaria Virgen de las Nieves. Granada (Spain).
Abstract
Hematogones are normal B-lymphoid precursors that multiply in the bone marrow of small children and of adults with ferropenic anaemia, neuroblastoma or idiopathic thrombocytopenic purpura. They are not normally found in peripheral blood, and the immunophenotype is virtually indistinguishable from that of B lymphoblasts. We discuss the case of a 3-month infant with an active cytomegalovirus infection, with hepatitis and pancytopenia associated with 13% hematogones in the bone marrow.
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