Koji Kato,^1,2 Yuju Ohno,¹ Shoshu Mitsuyama,³ Satoshi Toyoshima,⁴ Junichi Ito,⁵ Hisashi Gondo,⁶ Mine Harada⁶

¹Department of Hematology, Kitakyushu Municipal Medical Center, Fukuoka, Japan. ²Blood and Marrow Transplantation program, University of Michigan Comprehensive Cancer Center, Michigan, U.S.A. ³Department of Surgery, Kitakyushu Municipal Medical Center, Fukuoka, Japan. ⁴Department of Pathology, Kitakyushu Municipal Medical Center, Fukuoka, Japan. ⁵Ito Clinic, Fukuoka, Japan. ⁶Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.

Abstract:

Anaplastic thyroid carcinoma (ATC) is a tumor with bad prognosis and long-term survival is very low. However, appropriate combinations of chemotherapy, surgery, and radition have been reported to potentially improve the treatment results for ATC. We describe a case of refractory ATC successfully treated with high-dose chemotherapy (HDC) followed by autologous peripheral blood stem cell transplantation (auto-PBSCT). There has not been any evidence of recurrence for 10 years after auto-PBSCT. To the best of our knowledge, this is the first case of ATC that has been followed up for a longterm period after HDC with auto-PBSCT. This case suggests that intensive therapeutic approach such as HDC with auto- PBSCT may be useful.