Acute Visual Loss Induced by Dexamethasone During Neoadjuvant Docetaxol
D.L. Gregory1, C.D. Jones2, E.R.E. Denton3 and A.N. Harnett4
1Department of Oncology, Addenbrookes Hospital, Cambridge, UK. 2Department of Ophthalmology, Norfolk and Norwich University Hospital Norwich, UK. 3Department of Radiology, Norfolk and Norwich University Hospital Norwich, UK. 4Department of Oncology, Norfolk and Norwich University Hospital Norwich, UK.
Abstract
We present a case of a female patient who developed acute onset of visual loss due to central serous retinopathy as a consequence of steroid premedication for docetaxol given as second line neoadjuvant chemotherapy for breast cancer. Central serous retinopathy is a recognised association with steroids but has not been previously reported in association with the management of solid tumours. Reduction in steroid dose and duration permitted recovery of her visual acuity while allowing completion of the prescribed chemotherapy regimen. An overview of the presentation, pathogenesis, aetiologies and management of central serous retinopathy is given.
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