The world wide web has furthered the emergence of a multitude of online expert communities. Continued progress on many of the remaining complex scientific questions requires a wide ranging expertise spectrum with access to a variety of distinct data types. Moving beyond peer-to-peer to community-to-community interaction is therefore one of the biggest challenges for global interdisciplinary Life Sciences research, including that of cancer. Cross-domain data query, access, and retrieval will be important innovation areas to enable and facilitate this interaction in the coming years.