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Letter to the Editor: Does Dicer Expression Affect shRNA Processing?

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Authors: Neil Senzer, Donald Rao and John Nemunaitis

Publication Date: 19 Jun 2009

Type: Letter to Editor

Journal: Gene Regulation and Systems Biology

Citation: Gene Regulation and Systems Biology 2009:3 103-104

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Abstract

Elevated Dicer and Drosha mRNA levels have been documented across a range of tumor types (including ovarian carcinoma) by a number of investigators without any demonstrable correlation with patient survival nor evidence of interference with shRNA processing. A recent publication by Merritt et al. (NEJM 359(25):2641-50, 2008) reporting their findings in patients with ovarian carcinoma reach opposite conclusions. Further study will be needed to resolve this issue.

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