Posted Wed, Jan, 16,2013
Published today in Gene Regulation and Systems Biology is a new original research article by Bolaji N. Thomas, Tanya J. Thakur, Li Yi, Aldiouma Guindo, Dapa A. Diallo and Jurg Ott. Read more about this paper below:
Title:
Extensive Ethnogenomic Diversity of Endothelial Nitric Oxide Synthase (eNOS) Polymorphisms
Abstract:
Nitric oxide (NO) is highly reactive, produced in endothelial cells by endothelial NO synthase (eNOS) and has been implicated in sickle cell pathophysiology. We evaluated the distribution of functionally significant eNOS variants (the T786C variant in the promoter region, the Glu298Asp variant in exon 7, and the variable number of tandem repeats (VNTR) in intron 4) in Africans, African Americans and Caucasians. The C-786 variant was more common in Caucasians than in Africans and African Americans. Consistent with other findings, the Asp-298 variant had the highest frequency in Caucasians followed by African Americans, but was completely absent in Africans. The very rare intron 4 allele, eNOS 4c, was found in some Africans and African Americans, but not in Caucasians. eNOS 4d allele was present in 2 Africans. These findings suggest a consistent and widespread genomic diversity in the distribution of eNOS variants in Africans, comparative to African Americans and Caucasians.
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Thu 08 Oct, 2015
Published This Week (5th - 9th October)Thu 08 Oct, 2015
Biomarker Insights Paper Endorsed by Editor in ChiefWed 07 Oct, 2015
Interview with Professor Jamie DaviesThe submission process for publication in Clinical Medicine Insights: Case Reports is extremely smooth. The editors were very fast in their response and provided detailed instructions about all procedures. They were happy to answer to all our questions. The whole process was fast and efficient. Congratulations to Libertas Academica.
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