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Clinical Medicine: Therapeutics

Synopsis: An open access, peer reviewed electronic journal that covers therapeutics in human clinical medicine.


Indexing: 2 major databases.  Pubmed indexing for NIH-funded research.

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ISSN: 1179-1713



Aims and scope:

Clinical Medicine: Therapeutics focuses on the role of therapeutics in human clinical medicine.

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Submissions, excluding editorials, letters to the editor and dedications, will be peer reviewed by two reviewers.  Reviewers are required to provide fair, balanced and constructive reports.  

Under our Fairness in Peer Review Policy authors may appeal against reviewers' recommendations which are ill-founded, unobjective or unfair.  Appeals are considered by the Editor in Chief or Associate Editor.

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As of April 7 2008, the US NIH Public Access Policy requires that all peer reviewed articles resulting from research carried out with NIH funding be deposited in the Pubmed Central archive.

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Single Sevikar®: Combination Therapy for the Treatment of Hypertension

Authors: Eduardo Pimenta
Publication Date: 01 Jul 2009
Clinical Medicine: Therapeutics 2009:1 703-709

Eduardo Pimenta

Endocrine Hypertension Research Centre and Clinical Centre of Research Excellence in Cardiovascular Disease and Metabolic Disorders, University of Queensland School of Medicine, Greenslopes and Princess Alexandra Hospitals, Brisbane, QLD, Australia.

Abstract

Hypertension is one of the most important modifiable risk factor for cardiovascular morbidity and mortality and is highly prevalent. Recent guidelines and advisory statements have recommended lower thresholds and goals for patients with hypertension. However, approximately two-thirds of hypertensive patients do not achieve the goals. Poor adherence to anti-hypertensive medication regimens is a common cause of the practice-outcome gap. Monotherapy is also associated with difficulty to control blood pressure (BP) as most of hypertensive patients require 2 or more antihypertensive agents to effectively reduce BP. Therefore, current guidelines have recommended the use of combination therapy early in the management of hypertension or as first-line treatment. Fixed-dose combinations offer many advantages, such as convenience of use and fewer adverse events. Blockage of two or more BP regulatory systems also provides a more effective and physiologic BP reduction. Similar to other combinations, fixed-dose combination tablets containing dihydropyridine calcium channel blockers and angiotensin receptor blockers bring together two distinct and complementary mechanisms of action.



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