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Clinical Medicine: Therapeutics

Synopsis: An open access, peer reviewed electronic journal that covers therapeutics in human clinical medicine.


Indexing: 2 major databases.  Pubmed indexing for NIH-funded research.

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About this journal

ISSN: 1179-1713



Aims and scope:

Clinical Medicine: Therapeutics focuses on the role of therapeutics in human clinical medicine.

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Submissions, excluding editorials, letters to the editor and dedications, will be peer reviewed by two reviewers.  Reviewers are required to provide fair, balanced and constructive reports.  

Under our Fairness in Peer Review Policy authors may appeal against reviewers' recommendations which are ill-founded, unobjective or unfair.  Appeals are considered by the Editor in Chief or Associate Editor.

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As of April 7 2008, the US NIH Public Access Policy requires that all peer reviewed articles resulting from research carried out with NIH funding be deposited in the Pubmed Central archive.

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Pharmacotherapy of Retinal Diseases with Ranibizumab

Authors: Daniel F. Kiernan, Theodore K. Lin, Veeral Sheth and Rama D. Jager
Publication Date: 16 Apr 2009
Clinical Medicine: Therapeutics 2009:1 175-182

Daniel F. Kiernan1, Theodore K. Lin1, Veeral Sheth1 and Rama D. Jager1,2

1University of Chicago Hospitals, Section of Ophthalmology and Visual Sciences, Department of Surgery, 5841 S Maryland Ave—MC 2114, Chicago, IL 60637. 2University Retina and Macula Associates, 6320 W, 159th St., Suites A and D, Oak Forest, IL 60452.

Abstract

The development of new, abnormal and leaky blood vessels, termed choroidal neovascularization, causes loss of vision and quality of life as a result of many ocular diseases. A current therapy for a leading cause of irreversible blindness in older people in the United States, age-related macular degeneration, is intravitreal injection of ranibizumab. However, ranibizumab has also been used off-label to successfully treat a number of other ocular diseases causing significant ocular morbidity, including retinal vascular occlusion and diabetic macular edema. Despite its efficacy, the association of detectable serum levels of ranibizumab and arterial thromboembolic events in major follow-up studies since its approval by the United States Food and Drug Administration as well as its high cost relative to the possible existence of cheaper, equally efficacious alternatives has underscored the importance of understanding the mode of action and clinical utility of this novel pharmacotherapy.

Categories: Pharmacology , Opthalmology


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Posted by
University of Abu Dhabi
12:40,April 16, 2009

That is a great review. It is very interesting how many potential uses that ranibizumab has for ocular treatments, if only it were cheaper and more accessable for indigent populations! Strong work to Dr. jager's handsome young group for writing such a strong piece!


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