Clinical Medicine: Therapeutics
Synopsis: An open access, peer reviewed electronic journal that covers therapeutics in human clinical medicine.
Indexing: 2 major databases. Pubmed indexing for NIH-funded research.
Processing time: Decision in 2 weeks for 90% of papers.
Latest news:
Journal newsletter sent to subscribers in week 37, 2009. Follow link to see newsletter summary. Register to receive newsletters.
Experience with Cinacalcet for Secondary Hyperparathyroidism in Patients with Chronic Kidney Disease Stage III and IV
Authors: Terje Forslund, Arvo Koistinen and Marja Miettinen
Publication Date: 09 Jul 2009
Clinical Medicine: Therapeutics 2009:1 801-808
Terje Forslund, Arvo Koistinen and Marja Miettinen
Division of Nephrology, Department of Medicine, Central Finland Health Care District Hospital, Jyväskylä, Finland.
Abstract
Dysequilibrium in calcium and phosphate metabolism with development of secondary hyperparathyroidism (SHPT) is common in patients with chronic kidney disease (CKD) stage III and IV. Dietary phosphate restrictions and calcium based oral phosphate binders have not been effective in all subjects with SHPT, and soft tissue and vascular calcifications with an increased risk of cardiovascular death related are known consequences. Treatment with the calcimimetic Cinacalcet (Cc) has contributed to a better calcium and phosphate control in patients given hemodialysis treatment. In this retrospective study we present our experience with Cc given to ten (one year) or five (two years) patients with CKD stage III and IV and SHPT not suitable for surgery. With conventional therapy target levels of intact parathyroid hormon (iPTH) are seldomly reached the reason why an iPTH value < 300 ng/l was considered acceptable. Levels of iPTH decreased significantly after 3 months of Cc treatment and remained at the lower level. Plasma ionized-Ca (Ca) concentrations decreased initially but remained above 1.00 mmol/l in all but one patient. Phophate (P) levels increased to 1.41 ± 0.09 mmol/l (mean ± SE) leaving the Ca × P product unchanged. While patients with high iPTH needed high Cc doses up to 90 mg/day, some of the patients required very low doses 4.5–20 mg/day in order to achieve a decrease in iPTH levels. Only one patient reported gastric pain needing dose reduction and other adverse effects were not found. No changes in QT-time were observed. We experienced that Cc treatment was promising to control SHPT and stabilized the Ca-P balance in patients with CKD stage III and IV. Dosing may be challenging and laboratory values should be controlled often (monthly) as these patients may have variable response to Cc treatment. Due to the minimal knowledge about its effect on morbidity and mortality in the predialytic population further controlled studies are needed to confirm its efficacy and safety.
Categories: Pharmacology
Keywords: calcimimetic, cinacalcet, secondary hyperparathyroidism, chronic kidney disease, predialysis
Readers of this also read:
- Management of Transfusional Chronic Iron Overload: Focus on Deferasirox
- Safety and Efficacy of Lamotrigine in Older Adults with Epilepsy and Co-Morbid Depressive Symptoms
- Glimepiride-pioglitazone Hydrochloride in the Treatment of Type 2 Diabetes
- Tipranavir: A Review of its Use in Therapy of HIV Infection
- Bevacizumab: Its Place in the Treatment of Advanced Non-small Cell Lung Cancer
Sign up for free journal updates
Recently published in this journal 
Prophylaxis of Invasive Fungal Infections: A Review of the Use of Posaconazole
- 02/Oct/2009
Pharmacotherapy Options in Cancer Treatment-Induced Bone Loss: Focus on Bisphosphonates
- 25/Sep/2009
Current Rational to Prescribe Tigecycline: Critical Analysis of the Evidence and Usage Algorithms by an Argentinean Experts Panel
- 25/Sep/2009
Infliximab: A Review of its Use in the Treatment of Crohn’s Disease
- 25/Sep/2009
Metformin: A Review of its Use in the Treatment of Type 2 Diabetes
- 25/Sep/2009
Pharmacotherapy of Chronic Obstructive Pulmonary Disease: Focus on Arformoterol Tartrate
- 23/Sep/2009
A Review of Sildenafil in the Treatment of Pediatric Pulmonary Arterial Hypertension
- 23/Sep/2009
Collaboration to Meet a Therapeutic Need: The Development of Nelarabine
- 18/Sep/2009
Good News from Aliskiren?
- 17/Sep/2009
Present and Prospective Pharmacotherapies in Pulmonary Arterial Hypertension
- 17/Sep/2009
Tigecycline in the Treatment of Community-Acquired Pneumonia
- 17/Sep/2009
Pharmacotherapy of Chronic Hepatitis B in Adults: Focus on Tenofovir Disoproxil Fumarate
- 17/Sep/2009
Safety and Efficacy of Didanosine Enteric-Coated Capsule in Patients with HIV-1 Infection
- 17/Sep/2009
Aliskiren for the Treatment of Hypertension: An Update
- 15/Sep/2009
Montelukast: Pharmacology, Safety, Tolerability and Efficacy
- 15/Sep/2009
Rosiglitazone Maleate and Metformin Hydrochloride in Fixed Combination: What Role in the Treatment of Type 2 Diabetes?
- 10/Sep/2009
Pharmacotherapy of Bone Loss in Postmenopausal Women: Focus on Denosumab
- 09/Sep/2009
Ropinirole in the Treatment of Restless Legs Syndrome
- 09/Sep/2009
Pegylated Liposomal Doxorubicin for Advanced Ovarian Cancer in Women who are Refractory to Both Platinum- and Paclitaxel-Based Chemotherapy Regimens
- 09/Sep/2009
Azacitidine: A Review of its Use in the Management of Myelodysplastic Syndromes
- 07/Sep/2009
A Review of the Prevention of Invasive Breast Cancer with Raloxifene in Postmenopausal Women
- 07/Sep/2009
Pharmacotherapy of Restless Legs Syndrome with Pramipexole
- 07/Sep/2009
Pharmacotherapy Update: Risperidone in the Treatment of Schizophrenia
- 07/Sep/2009
Palonosetron Hydrochloride in the Treatment of Chemotherapy-Induced Nausea and Vomiting
- 03/Sep/2009
A Review of Raltegravir and its Use in HIV-1 Infection
- 03/Sep/2009
A Re-assessment of the Safety and Efficacy of Interleukin-2 for the Treatment of Renal Cell Carcinoma
- 31/Aug/2009
Reduction in Risk of Myocardial Infarction, Stroke, and Death from Cardiovascular Causes. Focus on Rampiril
- 31/Aug/2009
Cardiotoxicity of Oral Methadone as an Analgesic - Recommendations for Safe Use
- 31/Aug/2009
Safety and Efficacy of Doxycycline
- 27/Aug/2009
Present and Prospective Pharmacotherapy for the Management of Patients with Type 2 Diabetes
- 27/Aug/2009
Exudative Age-Related Macular Degeneration: Current Therapies and Potential Treatments
- 27/Aug/2009
Safety and Efficacy of Eplerenone in the Management of Essential Hypertension
- 25/Aug/2009
Antipsychotic Drug Treatment for Patients with Schizophrenia: Theoretical Background, Clinical Considerations and Patient Preferences
- 17/Aug/2009
Benefits of ACE Inhibitors in Diabetes
- 14/Aug/2009
Insomnia: A Review of the Use of Eszopiclone
- 12/Aug/2009
Management of EGFR-Mutant Non-Small Cell Lung Cancer: Focus on Gefitinib
- 12/Aug/2009
Clopidogrel Bisulfate: A Review of its Use in the Management of Acute Coronary Syndrome
- 07/Aug/2009
A Review of Enteric-coated Mycophenolate Sodium for Renal Transplant Immunosuppression
- 07/Aug/2009
Pharmacotherapy of Epilepsy: Focus on Levetiracetam
- 05/Aug/2009
Current and Prospective Pharmacotherapies in Gastroesophageal Reflux Disease
- 05/Aug/2009
Pharmacotherapy of Candida Infections with Echinocandins
- 04/Aug/2009
Management Options in Chronic Stable Angina Pectoris: Focus on Ranolazine
- 31/Jul/2009
Pharmacotherapy with Pamidronate Disodium of Osteolytic Bone Metastases of Breast Cancer, Osteolytic Lesions of Multiple Myeloma, and Paget’s Disease
- 30/Jul/2009
Pharmacotherapy of Hematologic Malignancies with Tipifarnib
- 29/Jul/2009
Zolmitriptan and the Triptan Era
- 22/Jul/2009
Pharmacotherapy of Complicated Urinary Tract and Intra-abdominal Infections with Doripenem
- 15/Jul/2009
Glimepiride-pioglitazone Hydrochloride in the Treatment of Type 2 Diabetes
- 15/Jul/2009
Safety and Efficacy of the bi-Sulfydryl ACE-Inhibitor Zofenopril in the Management of Cardiovascular Disease
- 15/Jul/2009
Pregabalin and Fibromyalgia Syndrome: A Treatment Option
- 15/Jul/2009
Bevacizumab: Its Place in the Treatment of Advanced Non-small Cell Lung Cancer
- 13/Jul/2009
Safety and Efficacy of Lamotrigine in Older Adults with Epilepsy and Co-Morbid Depressive Symptoms
- 09/Jul/2009
Management of Transfusional Chronic Iron Overload: Focus on Deferasirox
- 09/Jul/2009
Experience with Cinacalcet for Secondary Hyperparathyroidism in Patients with Chronic Kidney Disease Stage III and IV
- 09/Jul/2009
Tipranavir: A Review of its Use in Therapy of HIV Infection
- 09/Jul/2009
Single Sevikar®: Combination Therapy for the Treatment of Hypertension
- 01/Jul/2009
Safety and Efficacy of I(131) Tositumomab in the Treatment of non-Hodgkin’s Lymphoma
- 01/Jul/2009
Triptans in the Treatment of Migraine
- 01/Jul/2009
Treatment Options in Smoking Cessation: What Place for Bupropion Sustained-Release?
- 30/Jun/2009
Tetrabenazine in Huntington’s Disease Chorea
- 29/Jun/2009
Pharmacokinetics of Lopinavir in the LPV/R-Meltrex Formulation Compared to the LPV/R-Soft Gelatine Capsule in HIV Infected Patients
- 29/Jun/2009
Pharmacotherapy Update: Hyoscine Butylbromide in the Treatment of Abdominal Spasms
- 23/Jun/2009
Pharmacotherapy Update: Quetiapine use in Bipolar Disorder - What does the evidence tell us?
- 19/Jun/2009
Emerging Therapies for the Treatment of Essential Tremor
- 17/Jun/2009
Safety and Efficacy of Panitumumab in the Treatment of Metastatic Colorectal Cancer
- 12/Jun/2009
Lapatinib in the Treatment of Breast Cancer
- 12/Jun/2009
Secondary Stroke Prevention, and the Role of Antiplatelet Therapies
- 11/Jun/2009
First-line Treatment of Metastatic Breast Cancer: Focus on Bevacizumab
- 10/Jun/2009
A Review of Trastuzumab-Based Therapy in Patients with HER2-positive Metastatic Breast Cancer
- 08/Jun/2009
Hormone Refractory Prostate Cancer: Focus on Sipuleucel-T
- 08/Jun/2009
Pharmacotherapy of Excessive Sleepiness: Focus on Armodafinil
- 28/May/2009
Safety and Efficacy of Ambrisentan in the Treatment of Pulmonary Arterial Hypertension
- 27/May/2009
Therapeutic Options in Multiple Myeloma: Focus on Bortezomib
- 26/May/2009
A Review of Nelarabine in the Treatment of T-cell Lymphoblastic Leukemia/Lymphoma
- 21/May/2009
A Review of Levofloxacin for the Treatment of Bacterial Infections
- 15/May/2009
Pharmacotherapy of HIV: Focus on Etravirine
- 15/May/2009
The Prevention of Respiratory Syncytial Virus Infection in Children: Focus on Palivizumab
- 14/May/2009
Safety and Efficacy Review of Doxycycline
- 14/May/2009
Pharmacotherapy Update: Fludarabine in the Treatment of Non-Hodgkin’s Lymphoma
- 11/May/2009
A Review of the Pharmacokinetics, Pharmacodynamics and Efficacy of Zolmitriptan in the Acute Abortive Treatment of Migraine
- 11/May/2009
Metastatic Bone Disease in Patients with Solid Tumors—Burden of Bone Disease and the Role of Zoledronic Acid
- 08/May/2009
Lanreotide Autogel® in the Treatment of Acromegaly
- 07/May/2009
Sorafenib in Hepatocellular Carcinoma
- 06/May/2009
Hypertension Management and End Organ Protection: Focus on Aliskiren
- 01/May/2009
Pharmacotherapy of Oral Mucositis with Palifermin
- 01/May/2009
The Rise and Fall of Rosiglitazone
- 30/Apr/2009
Pharmacotherapy of Systemic Sclerosis: focus on Bosentan
- 16/Apr/2009
Efficacy and safety of fixed-dose Lercanidipine-Enalapril for the treatment of hypertension
- 20/Apr/2009
Current Approaches to the Treatment of Gastrointestinal Infections: Focus on Nitazoxanide
- 20/Apr/2009
A Review of Pramlintide in the Management of Diabetes
- 19/Apr/2009
Safety and Efficacy of Pioglitazone/Metformin Combination Therapy in Treatment of Type 2 Diabetes: A Rationale for Earlier Use
- 17/Apr/2009
Pharmacotherapy Options in Atrial Fibrillation: Focus on Vernakalant
- 17/Apr/2009
Pharmacotherapy of Retinal Diseases with Ranibizumab
- 16/Apr/2009
Sitaxentan for the Oral Treatment of Pulmonary Arterial Hypertension: Benefits from Endothelin Receptor Subtype Selectivity?
- 16/Apr/2009
Pharmacotherapy of HIV: A Focus on Atazanavir/Ritonavir a Potent and Convenient Once Daily Ritonavir Boosted Protease-Inhibitor for HIV-1 Infected Adults
- 09/Apr/2009
Hypertension: Focus on Olmesartan Medoxomil
- 08/Apr/2009
Pharmacotherapy of Paget’s Disease of Bone: Focus on Zoledronic Acid
- 08/Apr/2009
A Review of Delayed-Release MMX Mesalamine: It’s Use in the Treatment of Ulcerative Colitis
- 07/Apr/2009
Raltegravir: Its use in the Treatment of HIV Infection
- 03/Apr/2009
Efficacy and Safety of Sitagliptin in the Treatment of Type 2 Diabetes
- 03/Apr/2009
Management of Asthma with ICS and LABAs: different treatment strategies
- 03/Apr/2009
- 02/Oct/2009
Pharmacotherapy Options in Cancer Treatment-Induced Bone Loss: Focus on Bisphosphonates
- 25/Sep/2009
Current Rational to Prescribe Tigecycline: Critical Analysis of the Evidence and Usage Algorithms by an Argentinean Experts Panel
- 25/Sep/2009
Infliximab: A Review of its Use in the Treatment of Crohn’s Disease
- 25/Sep/2009
Metformin: A Review of its Use in the Treatment of Type 2 Diabetes
- 25/Sep/2009
Pharmacotherapy of Chronic Obstructive Pulmonary Disease: Focus on Arformoterol Tartrate
- 23/Sep/2009
A Review of Sildenafil in the Treatment of Pediatric Pulmonary Arterial Hypertension
- 23/Sep/2009
Collaboration to Meet a Therapeutic Need: The Development of Nelarabine
- 18/Sep/2009
Good News from Aliskiren?
- 17/Sep/2009
Present and Prospective Pharmacotherapies in Pulmonary Arterial Hypertension
- 17/Sep/2009
Tigecycline in the Treatment of Community-Acquired Pneumonia
- 17/Sep/2009
Pharmacotherapy of Chronic Hepatitis B in Adults: Focus on Tenofovir Disoproxil Fumarate
- 17/Sep/2009
Safety and Efficacy of Didanosine Enteric-Coated Capsule in Patients with HIV-1 Infection
- 17/Sep/2009
Aliskiren for the Treatment of Hypertension: An Update
- 15/Sep/2009
Montelukast: Pharmacology, Safety, Tolerability and Efficacy
- 15/Sep/2009
Rosiglitazone Maleate and Metformin Hydrochloride in Fixed Combination: What Role in the Treatment of Type 2 Diabetes?
- 10/Sep/2009
Pharmacotherapy of Bone Loss in Postmenopausal Women: Focus on Denosumab
- 09/Sep/2009
Ropinirole in the Treatment of Restless Legs Syndrome
- 09/Sep/2009
Pegylated Liposomal Doxorubicin for Advanced Ovarian Cancer in Women who are Refractory to Both Platinum- and Paclitaxel-Based Chemotherapy Regimens
- 09/Sep/2009
Azacitidine: A Review of its Use in the Management of Myelodysplastic Syndromes
- 07/Sep/2009
A Review of the Prevention of Invasive Breast Cancer with Raloxifene in Postmenopausal Women
- 07/Sep/2009
Pharmacotherapy of Restless Legs Syndrome with Pramipexole
- 07/Sep/2009
Pharmacotherapy Update: Risperidone in the Treatment of Schizophrenia
- 07/Sep/2009
Palonosetron Hydrochloride in the Treatment of Chemotherapy-Induced Nausea and Vomiting
- 03/Sep/2009
A Review of Raltegravir and its Use in HIV-1 Infection
- 03/Sep/2009
A Re-assessment of the Safety and Efficacy of Interleukin-2 for the Treatment of Renal Cell Carcinoma
- 31/Aug/2009
Reduction in Risk of Myocardial Infarction, Stroke, and Death from Cardiovascular Causes. Focus on Rampiril
- 31/Aug/2009
Cardiotoxicity of Oral Methadone as an Analgesic - Recommendations for Safe Use
- 31/Aug/2009
Safety and Efficacy of Doxycycline
- 27/Aug/2009
Present and Prospective Pharmacotherapy for the Management of Patients with Type 2 Diabetes
- 27/Aug/2009
Exudative Age-Related Macular Degeneration: Current Therapies and Potential Treatments
- 27/Aug/2009
Safety and Efficacy of Eplerenone in the Management of Essential Hypertension
- 25/Aug/2009
Antipsychotic Drug Treatment for Patients with Schizophrenia: Theoretical Background, Clinical Considerations and Patient Preferences
- 17/Aug/2009
Benefits of ACE Inhibitors in Diabetes
- 14/Aug/2009
Insomnia: A Review of the Use of Eszopiclone
- 12/Aug/2009
Management of EGFR-Mutant Non-Small Cell Lung Cancer: Focus on Gefitinib
- 12/Aug/2009
Clopidogrel Bisulfate: A Review of its Use in the Management of Acute Coronary Syndrome
- 07/Aug/2009
A Review of Enteric-coated Mycophenolate Sodium for Renal Transplant Immunosuppression
- 07/Aug/2009
Pharmacotherapy of Epilepsy: Focus on Levetiracetam
- 05/Aug/2009
Current and Prospective Pharmacotherapies in Gastroesophageal Reflux Disease
- 05/Aug/2009
Pharmacotherapy of Candida Infections with Echinocandins
- 04/Aug/2009
Management Options in Chronic Stable Angina Pectoris: Focus on Ranolazine
- 31/Jul/2009
Pharmacotherapy with Pamidronate Disodium of Osteolytic Bone Metastases of Breast Cancer, Osteolytic Lesions of Multiple Myeloma, and Paget’s Disease
- 30/Jul/2009
Pharmacotherapy of Hematologic Malignancies with Tipifarnib
- 29/Jul/2009
Zolmitriptan and the Triptan Era
- 22/Jul/2009
Pharmacotherapy of Complicated Urinary Tract and Intra-abdominal Infections with Doripenem
- 15/Jul/2009
Glimepiride-pioglitazone Hydrochloride in the Treatment of Type 2 Diabetes
- 15/Jul/2009
Safety and Efficacy of the bi-Sulfydryl ACE-Inhibitor Zofenopril in the Management of Cardiovascular Disease
- 15/Jul/2009
Pregabalin and Fibromyalgia Syndrome: A Treatment Option
- 15/Jul/2009
Bevacizumab: Its Place in the Treatment of Advanced Non-small Cell Lung Cancer
- 13/Jul/2009
Safety and Efficacy of Lamotrigine in Older Adults with Epilepsy and Co-Morbid Depressive Symptoms
- 09/Jul/2009
Management of Transfusional Chronic Iron Overload: Focus on Deferasirox
- 09/Jul/2009
Experience with Cinacalcet for Secondary Hyperparathyroidism in Patients with Chronic Kidney Disease Stage III and IV
- 09/Jul/2009
Tipranavir: A Review of its Use in Therapy of HIV Infection
- 09/Jul/2009
Single Sevikar®: Combination Therapy for the Treatment of Hypertension
- 01/Jul/2009
Safety and Efficacy of I(131) Tositumomab in the Treatment of non-Hodgkin’s Lymphoma
- 01/Jul/2009
Triptans in the Treatment of Migraine
- 01/Jul/2009
Treatment Options in Smoking Cessation: What Place for Bupropion Sustained-Release?
- 30/Jun/2009
Tetrabenazine in Huntington’s Disease Chorea
- 29/Jun/2009
Pharmacokinetics of Lopinavir in the LPV/R-Meltrex Formulation Compared to the LPV/R-Soft Gelatine Capsule in HIV Infected Patients
- 29/Jun/2009
Pharmacotherapy Update: Hyoscine Butylbromide in the Treatment of Abdominal Spasms
- 23/Jun/2009
Pharmacotherapy Update: Quetiapine use in Bipolar Disorder - What does the evidence tell us?
- 19/Jun/2009
Emerging Therapies for the Treatment of Essential Tremor
- 17/Jun/2009
Safety and Efficacy of Panitumumab in the Treatment of Metastatic Colorectal Cancer
- 12/Jun/2009
Lapatinib in the Treatment of Breast Cancer
- 12/Jun/2009
Secondary Stroke Prevention, and the Role of Antiplatelet Therapies
- 11/Jun/2009
First-line Treatment of Metastatic Breast Cancer: Focus on Bevacizumab
- 10/Jun/2009
A Review of Trastuzumab-Based Therapy in Patients with HER2-positive Metastatic Breast Cancer
- 08/Jun/2009
Hormone Refractory Prostate Cancer: Focus on Sipuleucel-T
- 08/Jun/2009
Pharmacotherapy of Excessive Sleepiness: Focus on Armodafinil
- 28/May/2009
Safety and Efficacy of Ambrisentan in the Treatment of Pulmonary Arterial Hypertension
- 27/May/2009
Therapeutic Options in Multiple Myeloma: Focus on Bortezomib
- 26/May/2009
A Review of Nelarabine in the Treatment of T-cell Lymphoblastic Leukemia/Lymphoma
- 21/May/2009
A Review of Levofloxacin for the Treatment of Bacterial Infections
- 15/May/2009
Pharmacotherapy of HIV: Focus on Etravirine
- 15/May/2009
The Prevention of Respiratory Syncytial Virus Infection in Children: Focus on Palivizumab
- 14/May/2009
Safety and Efficacy Review of Doxycycline
- 14/May/2009
Pharmacotherapy Update: Fludarabine in the Treatment of Non-Hodgkin’s Lymphoma
- 11/May/2009
A Review of the Pharmacokinetics, Pharmacodynamics and Efficacy of Zolmitriptan in the Acute Abortive Treatment of Migraine
- 11/May/2009
Metastatic Bone Disease in Patients with Solid Tumors—Burden of Bone Disease and the Role of Zoledronic Acid
- 08/May/2009
Lanreotide Autogel® in the Treatment of Acromegaly
- 07/May/2009
Sorafenib in Hepatocellular Carcinoma
- 06/May/2009
Hypertension Management and End Organ Protection: Focus on Aliskiren
- 01/May/2009
Pharmacotherapy of Oral Mucositis with Palifermin
- 01/May/2009
The Rise and Fall of Rosiglitazone
- 30/Apr/2009
Pharmacotherapy of Systemic Sclerosis: focus on Bosentan
- 16/Apr/2009
Efficacy and safety of fixed-dose Lercanidipine-Enalapril for the treatment of hypertension
- 20/Apr/2009
Current Approaches to the Treatment of Gastrointestinal Infections: Focus on Nitazoxanide
- 20/Apr/2009
A Review of Pramlintide in the Management of Diabetes
- 19/Apr/2009
Safety and Efficacy of Pioglitazone/Metformin Combination Therapy in Treatment of Type 2 Diabetes: A Rationale for Earlier Use
- 17/Apr/2009
Pharmacotherapy Options in Atrial Fibrillation: Focus on Vernakalant
- 17/Apr/2009
Pharmacotherapy of Retinal Diseases with Ranibizumab
- 16/Apr/2009
Sitaxentan for the Oral Treatment of Pulmonary Arterial Hypertension: Benefits from Endothelin Receptor Subtype Selectivity?
- 16/Apr/2009
Pharmacotherapy of HIV: A Focus on Atazanavir/Ritonavir a Potent and Convenient Once Daily Ritonavir Boosted Protease-Inhibitor for HIV-1 Infected Adults
- 09/Apr/2009
Hypertension: Focus on Olmesartan Medoxomil
- 08/Apr/2009
Pharmacotherapy of Paget’s Disease of Bone: Focus on Zoledronic Acid
- 08/Apr/2009
A Review of Delayed-Release MMX Mesalamine: It’s Use in the Treatment of Ulcerative Colitis
- 07/Apr/2009
Raltegravir: Its use in the Treatment of HIV Infection
- 03/Apr/2009
Efficacy and Safety of Sitagliptin in the Treatment of Type 2 Diabetes
- 03/Apr/2009
Management of Asthma with ICS and LABAs: different treatment strategies
- 03/Apr/2009
Related journals...
Clinical Medicine: Therapeutics
Garry Walsh, Editor in Chief
Submit a paper
Share this journal
 |
|
 |
YAHOO! BUZZ |
 |
DIGG |
 |
|
 |
MIXX |
 |
PERMALINK |
 |
GOOGLE BOOKMARKS |
 |
DELICIOUS |
 |
|
 |
NEWSVINE |
Recent news
Open access articles published in September - 02/Oct/2009
Announcing the Indian Journal of Clinical Medicine - 30/Sep/2009
Autism Insights launched - 29/Sep/2009
Newsletter summary (week 37, 2009) - 25/Sep/2009
Interview with Clinical Medicine: Cardiology editorial board member Dr Vernon Barnes - 25/Sep/2009
Interview with Cancer Informatics editorial board member Dr Grant Izmirlian - 22/Sep/2009
Call for papers for Analytical Chemistry Insights from Dr Gabor Patonay - 22/Sep/2009
Sponsor the IBM-OCI Integrative Discovery team in Ride to Conquer Cancer - 15/Sep/2009
No article processing fees for selected journals - 25/Sep/2009
Newsletter summary (week 36, 2009) - 15/Sep/2009
Interview with Healthy Aging and Clinical Care in the Elderly editorial board member Dr Davide Malatesta - 15/Sep/2009
Interview with Translational Oncogenomics author Dr David Frank - 10/Sep/2009
Interview with Retrovirology: Research and Treatment author Dr Elcio Leal - 10/Sep/2009
Interview with Microbiology Insights author Dr Tinatin Doolotkedlieva - 10/Sep/2009
Call for papers for Drug Target Insights by Dr Monica Milani - 10/Sep/2009
Call for papers for Clinical Medicine: Urology from Dr Xiangyi Lu - 10/Sep/2009
Research profile on Gene Regulation and Systems Biology author Dr Noboru Uchide - 09/Sep/2009
Interview with Biomarker Insights editorial board member Dr Lawrence Cheskin - 07/Sep/2009
Newsletter summary (week 35, 2009) - 04/Sep/2009
Research profile of Clinical Medicine: Endocrinology and Diabetes author Dr Hiro Koshiyama - 04/Sep/2009
Announcing the Indian Journal of Clinical Medicine - 30/Sep/2009
Autism Insights launched - 29/Sep/2009
Newsletter summary (week 37, 2009) - 25/Sep/2009
Interview with Clinical Medicine: Cardiology editorial board member Dr Vernon Barnes - 25/Sep/2009
Interview with Cancer Informatics editorial board member Dr Grant Izmirlian - 22/Sep/2009
Call for papers for Analytical Chemistry Insights from Dr Gabor Patonay - 22/Sep/2009
Sponsor the IBM-OCI Integrative Discovery team in Ride to Conquer Cancer - 15/Sep/2009
No article processing fees for selected journals - 25/Sep/2009
Newsletter summary (week 36, 2009) - 15/Sep/2009
Interview with Healthy Aging and Clinical Care in the Elderly editorial board member Dr Davide Malatesta - 15/Sep/2009
Interview with Translational Oncogenomics author Dr David Frank - 10/Sep/2009
Interview with Retrovirology: Research and Treatment author Dr Elcio Leal - 10/Sep/2009
Interview with Microbiology Insights author Dr Tinatin Doolotkedlieva - 10/Sep/2009
Call for papers for Drug Target Insights by Dr Monica Milani - 10/Sep/2009
Call for papers for Clinical Medicine: Urology from Dr Xiangyi Lu - 10/Sep/2009
Research profile on Gene Regulation and Systems Biology author Dr Noboru Uchide - 09/Sep/2009
Interview with Biomarker Insights editorial board member Dr Lawrence Cheskin - 07/Sep/2009
Newsletter summary (week 35, 2009) - 04/Sep/2009
Research profile of Clinical Medicine: Endocrinology and Diabetes author Dr Hiro Koshiyama - 04/Sep/2009
Similar papers
Chaperone Therapy for Neuronopathic Lysosomal Diseases: Competitive Inhibitors as Chemical Chaperones for Enhancement of Mutant Enzyme Activities - 26/May/2009
Aminoglycosides: Molecular Insights on the Recognition of RNA and Aminoglycoside Mimics - 28/Apr/2009
Perspectives on Using Physcomitrella Patens as an Alternative Production Platform for Thapsigargin and Other Terpenoid Drug Candidates - 04/Mar/2009
Bioactive and Structural Metabolites of Pseudomonas and Burkholderia Species Causal Agents of Cultivated Mushrooms Diseases - 09/May/2008
The Role of Integrins in Cancer and the Development of Anti-Integrin Therapeutic Agents for Cancer Therapy - 10/Apr/2008
Drug Targeting of α-Synuclein Oligomerization in Synucleinopathies - 10/Apr/2008
Lunasin: A Novel Cancer Preventive Seed Peptide - 25/Mar/2008
Effects of FK506 on Ca2+ Release Channels (Review) - 18/Mar/2008
Small Family with Key Contacts: Par14 and Par17 Parvulin Proteins, Relatives of Pin1, Now Emerge in Biomedical Research - 07/Mar/2008
Modifications of Antiepileptic Drugs for Improved Tolerability and Efficacy - 14/Feb/2008
Exploratory Studies on Development of the Chemokine Receptor CXCR4 Antagonists Toward Downsizing - 10/Feb/2008
The Role of Glucose Metabolism and Glucose-Associated Signalling in Cancer - 18/Jan/2008
Chemical Chaperone and Inhibitor Discovery: Potential Treatments for Protein Conformational Diseases - 11/Dec/2007
Derivatives of 5-Aminolevulinic Acid for Photodynamic Therapy - 11/Dec/2007
The pKa Distribution of Drugs: Application to Drug Discovery - 17/Sep/2007
Aminoglycosides: Molecular Insights on the Recognition of RNA and Aminoglycoside Mimics - 28/Apr/2009
Perspectives on Using Physcomitrella Patens as an Alternative Production Platform for Thapsigargin and Other Terpenoid Drug Candidates - 04/Mar/2009
Bioactive and Structural Metabolites of Pseudomonas and Burkholderia Species Causal Agents of Cultivated Mushrooms Diseases - 09/May/2008
The Role of Integrins in Cancer and the Development of Anti-Integrin Therapeutic Agents for Cancer Therapy - 10/Apr/2008
Drug Targeting of α-Synuclein Oligomerization in Synucleinopathies - 10/Apr/2008
Lunasin: A Novel Cancer Preventive Seed Peptide - 25/Mar/2008
Effects of FK506 on Ca2+ Release Channels (Review) - 18/Mar/2008
Small Family with Key Contacts: Par14 and Par17 Parvulin Proteins, Relatives of Pin1, Now Emerge in Biomedical Research - 07/Mar/2008
Modifications of Antiepileptic Drugs for Improved Tolerability and Efficacy - 14/Feb/2008
Exploratory Studies on Development of the Chemokine Receptor CXCR4 Antagonists Toward Downsizing - 10/Feb/2008
The Role of Glucose Metabolism and Glucose-Associated Signalling in Cancer - 18/Jan/2008
Chemical Chaperone and Inhibitor Discovery: Potential Treatments for Protein Conformational Diseases - 11/Dec/2007
Derivatives of 5-Aminolevulinic Acid for Photodynamic Therapy - 11/Dec/2007
The pKa Distribution of Drugs: Application to Drug Discovery - 17/Sep/2007