Clinical Medicine: Therapeutics
Synopsis: An open access, peer reviewed electronic journal that covers therapeutics in human clinical medicine.
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Clinical Medicine: Therapeutics focuses on the role of therapeutics in human clinical medicine.
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Reduction in Risk of Myocardial Infarction, Stroke, and Death from Cardiovascular Causes. Focus on Rampiril
M. Khazaei1, AM. Sharifi2,3, S. Golbidi4 and I. Laher4
1Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran. 2Department of Pharmacology and Cellular and Molecular Research Center; 3Razi Institute for Drug Research, Iran University of Medical Sciences, Tehran, Iran. 4Department of Pharmacology and Therapeutics, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.
Abstract
Several clinical studies demonstrate a beneficial role of angiotensin-converting enzyme (ACE) inhibitors in patients with myocardial infarction, hypertension and diabetes mellitus. This review focuses on the effects of ramipril, a weak inhibitor of ACE that is rapidly hydrolyzed to ramiprilat, an active metabolite. The Heart Outcome Prevention Evaluation (HOPE) study evaluated the effects of ramipril in patients with a high risk for cardiovascular events without pre-existing left ventricular dysfunction or heart failure. In this review, we summarized the effects of ramipril on myocardial infarction, death, diabetes mellitus, and stroke.
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