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Perspectives in Medicinal Chemistry

Synopsis: An open access, peer reviewed electronic journal that covers drug design in the form of commentaries and reviews which do not require disclosure of proprietary information.


Indexing: 4 major databases. Pubmed indexing for NIH-funded research.

Processing time: Decision in 2 weeks for 90% of papers.

Visibility: Most popular article read 1100+ times.

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About this journal

ISSN: 1177-391X


Aims:

Perspectives in Medicinal Chemistry (PMC) is an exciting peer-reviewed open access on-line journal. It was developed to help medicinal chemists keep apace with the expanding volume of information published in their field. Rather than providing exhaustive reviews of published work, PMC calls upon leading researchers to succinctly summarize observations from numerous original publications as hybrid review-commentaries. These articles are published continually on the website and are often commissioned by the Editor in Chief. While the submission of completed manuscripts is acceptable, we encourage proposals for future articles sent to the Managing Editor. These proposals should provide a rationale and brief outline (<250 words) for the article.

Scope:

Articles published in PMC are succinct and carefully-illustrated works intending to provide a thoughtful overview of a significant research area in medicinal chemistry. Importantly, these articles provide a representative but not exhaustive overview of recent advances in a particular research field. Articles in PMC provide insight on the implications of the new developments and provide an opportunity for authors to discuss their ideas of 'the road ahead' in their research areas. These articles are carefully peer-reviewed to ensure a balanced representation of the literature.

Perspectives in Medicinal Chemistry will publish articles that combine aspects of commentaries and reviews, allowing medicinal chemists to discuss drug design without the necessity of revealing proprietary information. Authors are encouraged to submit review-type manuscripts which go beyond conventional reviews by incorporating a sense of perspective to enhance articles' value to readers and to allow authors to demonstrate and share their perspectives in drug discovery.

Editorial standards and procedures:

Submissions, excluding editorials, letters to the editor and dedications, will be peer reviewed by two reviewers.  Reviewers are required to provide fair, balanced and constructive reports.  

Under our Fairness in Peer Review Policy authors may appeal against reviewers' recommendations which are ill-founded, unobjective or unfair.  Appeals are considered by the Editor in Chief or Associate Editor.

Papers are not sent to peer reviewers following submission of a revised manuscript. Editorial decisions on re-submitted papers are based on the author's response to the initial peer review report.

Indexing:

This journal is indexed by the following services:

  • Embase
  • Google Scholar
  • CAS
  • DOAJ

SPARC Europe Seal award winner:

This journal has been awarded a SPARC Europe Seal. The Seal is an initiative of SPARC Europe (Scholarly Publishing and Academic Resources Coalition) and the Directory of Open Access Journals (DOAJ) which is awarded to journals applying a Creative Commons CC-BY copyright license and that make journal metadata accessible to DOAJ.  

Amongst other important services DOAJ makes metadata OAI-compliant.  This in turn enhances the visibility of papers and allows OAI-harvesters to include the details of journal articles in their services. We encourage readers to make use of this valuable resource.  The DOAJ search page is available here.

National Institutes of Health Public Access Policy compliant:

As of April 7 2008, the US NIH Public Access Policy requires that all peer reviewed articles resulting from research carried out with NIH funding be deposited in the Pubmed Central archive.

If you are an NIH employee or grantee Libertas Academica will ensure that you comply with the policy by depositing your paper at Pubmed Central on your behalf. 



Editor in Chief's call for papers
 
 
 


Aminoglycosides: Molecular Insights on the Recognition of RNA and Aminoglycoside Mimics

Authors: Maruthi Chittapragada, Sarah Roberts and Young Wan Ham
Publication Date: 28 Apr 2009
Perspectives in Medicinal Chemistry 2009:3 21-37

Maruthi Chittapragada, Sarah Roberts and Young Wan Ham

Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT 84602, USA.

Abstract

RNA is increasingly recognized for its significant functions in biological systems and has recently become an important molecular target for therapeutics development. Aminoglycosides, a large class of clinically significant antibiotics, exert their biological functions by binding to prokaryotic ribosomal RNA (rRNA) and interfering with protein translation, resulting in bacterial cell death. They are also known to bind to viral mRNAs such as HIV-1 RRE and TAR. Consequently, aminoglycosides are accepted as the single most important model in understanding the principles that govern small molecule-RNA recognition, which is essential for the development of novel antibacterial, antiviral or even anti-oncogenic agents. This review outlines the chemical structures and mechanisms of molecular recognition and antibacterial activity of aminoglycosides and various aminoglycoside mimics that have recently been devised to improve biological efficacy, binding affinity and selectivity, or to circumvent bacterial resistance.

Categories: Pharmacology


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