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Perspectives in Medicinal Chemistry

Synopsis: An open access, peer reviewed electronic journal that covers drug design in the form of commentaries and reviews which do not require disclosure of proprietary information.


Indexing: 4 major databases. Pubmed indexing for NIH-funded research.

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About this journal

Aims:

Perspectives in Medicinal Chemistry (PMC) is an exciting peer-reviewed open access on-line journal. It was developed to help medicinal chemists keep apace with the expanding volume of information published in their field. Rather than providing exhaustive reviews of published work, PMC calls upon leading researchers to succinctly summarize observations from numerous original publications as hybrid review-commentaries. These articles are published continually on the website and are often commissioned by the Editor in Chief. While the submission of completed manuscripts is acceptable, we encourage proposals for future articles sent to the Managing Editor. These proposals should provide a rationale and brief outline (<250 words) for the article.

Scope:

Articles published in PMC are succinct and carefully-illustrated works intending to provide a thoughtful overview of a significant research area in medicinal chemistry. Importantly, these articles provide a representative but not exhaustive overview of recent advances in a particular research field. Articles in PMC provide insight on the implications of the new developments and provide an opportunity for authors to discuss their ideas of 'the road ahead' in their research areas. These articles are carefully peer-reviewed to ensure a balanced representation of the literature.

Perspectives in Medicinal Chemistry will publish articles that combine aspects of commentaries and reviews, allowing medicinal chemists to discuss drug design without the necessity of revealing proprietary information. Authors are encouraged to submit review-type manuscripts which go beyond conventional reviews by incorporating a sense of perspective to enhance articles' value to readers and to allow authors to demonstrate and share their perspectives in drug discovery.

Editorial standards and procedures:

Submissions, excluding editorials, letters to the editor and dedications, will be peer reviewed by two reviewers.  Reviewers are required to provide fair, balanced and constructive reports.  

Under our Fairness in Peer Review Policy authors may appeal against reviewers' recommendations which are ill-founded, unobjective or unfair.  Appeals are considered by the Editor in Chief or Associate Editor.

Papers are not sent to peer reviewers following submission of a revised manuscript. Editorial decisions on re-submitted papers are based on the author's response to the initial peer review report.

Indexing:

This journal is indexed by the following services:

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  • CAS
  • DOAJ

SPARC Europe Seal award winner:

This journal has been awarded a SPARC Europe Seal. The Seal is an initiative of SPARC Europe (Scholarly Publishing and Academic Resources Coalition) and the Directory of Open Access Journals (DOAJ) which is awarded to journals applying a Creative Commons CC-BY copyright license and that make journal metadata accessible to DOAJ.  

Amongst other important services DOAJ makes metadata OAI-compliant.  This in turn enhances the visibility of papers and allows OAI-harvesters to include the details of journal articles in their services. We encourage readers to make use of this valuable resource.  The DOAJ search page is available here.

National Institutes of Health Public Access Policy compliant:

As of April 7 2008, the US NIH Public Access Policy requires that all peer reviewed articles resulting from research carried out with NIH funding be deposited in the Pubmed Central archive.

If you are an NIH employee or grantee Libertas Academica will ensure that you comply with the policy by depositing your paper at Pubmed Central on your behalf. 

ISSN: 1177-3910


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Small Family with Key Contacts: Par14 and Par17 Parvulin Proteins, Relatives of Pin1, Now Emerge in Biomedical research

Authors: Jonathan W Mueller and Peter Bayer
Publication Date: 07 Mar 2008
Perspectives in Medicinal Chemistry 2008:2 11-20

Jonathan W Mueller1 and Peter Bayer1

1Institute for Structural and Medicinal Biochemistry, Centre for Medical Biotechnology—ZMB, University of Duisburg-Essen, 45117 Essen, Germany.

Abstract

The parvulin-type peptidyl-prolyl cis/trans isomerase Pin1 is subject of intense biochemical and clinical research as it seems to be involved in the pathogenesis of certain cancers and protein folding illnesses like Alzheimer’s and Parkinson’s disease. In addition to Pin1, the human genome only contains a single other parvulin locus encoding two protein species—Par14 and Par17. Much less is known about these enzymes although their sequences are highly conserved in all metazoans. Parvulin has been proposed to function as Pin1 complementing enzyme in cell cycle regulation and in chromatin remodelling. Pharmaceutical modulation of Par14 might therefore have benefi ts for certain types of cancer. Moreover, the Par17 protein that has been shown to be confi ned to anthropoid primate species only might provide a deeper understanding for human-specifi c brain development. This review aims at stimulating further research on Par14 and Par17 that are overlooked drug targets in the shadow of an overwhelming plethora of Pin1 literature by summarising all current knowledge on these parvulin proteins.

Categories: Pharmacology


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