Perspectives in Medicinal Chemistry
Synopsis: An open access, peer reviewed electronic journal that covers drug design in the form of commentaries and reviews which do not require disclosure of proprietary information.
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Lunasin: A Novel Cancer Preventive Seed Peptide
Authors: Blanca Hernández-Ledesma and Ben O. de Lumen
Publication Date: 25 Mar 2008
Perspectives in Medicinal Chemistry 2008:2 75-80
Blanca Hernández-Ledesma and Ben O. de Lumen
Department of Nutritional Sciences and Toxicology, University of California Berkeley, CA, 94720-3104, U.S.A.
Abstract
Cancer is one of the leading causes of deaths in the Western world. Approximately one-third of these deaths are preventable by lifestyle factors, including modification of nutritional habits. Studies have demonstrated that adequate nutrition with certain types of foods containing bioactive compounds might offer significant protection against carcinogenesis. Soybeans contain a variety of phytochemicals with demonstrated anticancer activity, including isoflavones, protease inhibitors, and more recently lunasin, a novel cancer preventive seed peptide. Initially isolated from soybean, lunasin has also been reported in barley and wheat. The purpose of this review is to summarize the most recent evidence on the possible benefits of lunasin for cancer prevention.
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