Home| About us| Widget| login/register| For authors| For reviewers |Submit a paper
(close)

(Ctrl-click to select multiple journals)


How should we address you?

Your email address


 Yes, sign up now
 Sign up for general news too

Privacy Statement
 
 
 

Biochemistry Insights

Synopsis: An open access, peer reviewed electronic journal that covers biochemistry.


Indexing: Three major databases. Pubmed indexing for NIH-funded research.

Processing time: Decision in 2 weeks for 90% of papers.

Visibility: Most popular article read 800+ times.

RSS

NEWS

TWITTER
View factor
for journal
33210


About this journal

ISSN: 1178-6264



Aims and scope:

Biochemistry Insights is a peer-reviewed, open-access online journal encompassing all topics within the field of biochemistry. This includes the chemistry, structure and functionality of proteins, carbohydrates, lipids, nucleic acids and smaller molecular components of cells and tissues. Cell metabolism, genomes, protein synthesis, cell signalling, transportation, and signal transduction are included but are not exclusive subjects. The journal also accepts articles on related topics applicable to this area, such as technology, outcomes, techniques and applications.

Editorial standards and procedures:

Submissions, excluding editorials, letters to the editor and dedications, will be peer reviewed by two reviewers.  Reviewers are required to provide fair, balanced and constructive reports.  

Under our Fairness in Peer Review Policy authors may appeal against reviewers' recommendations which are ill-founded, unobjective or unfair.  Appeals are considered by the Editor in Chief or Associate Editor.

Papers are not sent to peer reviewers following submission of a revised manuscript. Editorial decisions on re-submitted papers are based on the author's response to the initial peer review report.

Indexing:

This journal is indexed by:

  • CAS 
  • DOAJ
  • OAIster
National Institutes of Health Public Access Policy compliant:

As of April 7 2008, the US NIH Public Access Policy requires that all peer reviewed articles resulting from research carried out with NIH funding be deposited in the Pubmed Central archive.

If you are an NIH employee or grantee Libertas Academica will ensure that you comply with the policy by depositing your paper at Pubmed Central on your behalf. 



 
 
 


Renal Toxicity of Mercuric Chloride at Different Time Intervals in Rats

Authors: W.A. Al-Madani, N.J. Siddiqi and A.S. Alhomida
Publication Date: 23 Jun 2009
Biochemistry Insights 2009:2 37-45

W.A. Al-Madani1, N.J. Siddiqi2 and A.S. Alhomida2

1Division of Histopathology, Riyadh Armed Forces Hospital, Riyadh, Saudi Arabia. 2Department of Biochemistry, King Saud University, College of Science, PO Box 2455, Riyadh 11451, Saudi Arabia.

Abstract

This study was undertaken to study the renal toxicity of mercuric chloride in rats at different periods of time. The following groups of rats were studied: i) control, ii) placebo, iii) rats injected with a single ip dose of 100 mg/kg body weight of  2, 3 dimercapto- 1-propanesulfonic acid, iv) rats injected with a single ip dose of 100 mg/kg body weight of 2, 3 dimercapto-1-propanesulfonic acid (DMPS) followed by a single dose ip of 2.0 mg HgCl2/kg body weight one hour after DMPS injection v) rats injected with a single ip dose of 2.0 mg HgCl2/kg body weight. Results indicate that mercuric chloride was more toxic after 48 hours of its administration when compared to 24 hours. Mercuric chloride administration caused an impairment of renal function which was evident from a significant decrease in urine volume, urinary excretion of urea, creatinine and glomerular filteration rate (P < 0.001) when compared to other treated groups. There was an increased excretion of protein, albumin and γ—glutamyltransferase in the urine of mercuric chloride treated rats. Administration of 2, 3 dimercapto-1-propanesulfonic acid before mercuric chloride treatment caused the altered indices to return to near normal levels.

Categories: Biochemistry


Post comment




No comments yet...Be the first to comment.

Bookmark this article

LINKEDIN FACEBOOK

Add to Mixx! MIXX YAHOO! BUZZ

PERMALINK DIGG


Sign up for free journal updates

How should we address you?
Your email address
 Yes, sign up now


Recently published in this journal

Chelation Therapy for Mercury Poisoning
- 07/Aug/2009

Immune- and Pollution-mediated DNA Damage in Two Wild Mya arenaria Clam Populations
- 05/Aug/2009

Capsaicin - the Hot and Spicy Diet Turned Mild and Effective by Glycosylation
- 06/Jul/2009

Renal Toxicity of Mercuric Chloride at Different Time Intervals in Rats
- 23/Jun/2009

Prolonged Treatment with Free Fatty Acids has Post Receptor Effect in Hepatic Insulin Resistance: Evidence that Fatty Acids, Oleate and Palmitate have Insignificant Effect on the Insulin Receptor Beta In Vivo and Ex Vivo Primary Hepatocytes
- 12/Jun/2009

A Novel Mechanism in Regulating the Alpha-Subunit of the Epithelial Sodium Channel (α ENaC) by the Alternatively Spliced Form α ENaC-b
- 15/Apr/2009

A 20 Residues Motif Delineates the Furin Cleavage Site and its Physical Properties May Influence Viral Fusion
- 08/Apr/2009

Fast and Simple micro-RNA Northern Blots
- 04/Mar/2009

Production of (2R,3S)-2-Benzamidomethyl-3-Hydroxybutanoates by Immobilized Plant Cells of Parthenocissus Tricuspidata
- 06/Jan/2009

Use of a Combined Duplex PCR/Dot Blot Assay for more sensitive genetic characterization
- 06/Nov/2008

The Dual Nature of Metallothioneins in the Metabolism of Heavy Metals and Reactive Oxygen Species in Aquatic Organisms: Implications of Use as a Biomarker of Heavy-Metal Effects in Field Investigations
- 01/Sep/2008

Targeted Cancer Therapy with Tumor Necrosis Factor-Alpha
- 22/Jul/2008

A Changing Research and Publication Landscape for Biochemistry
- 25/Mar/2008



Related journals...