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Analytical Chemistry Insights

Synopsis: An open access, peer reviewed electronic journal that covers developments in the field including analytical methodology, techniques and instrumentation in the fundamental and applied areas of the field.


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About this journal

Aims and scope:

Analytical Chemistry Insights covers current developments in all areas of the field, including analytical methodology, techniques and instrumentation in the fundamental and applied areas of the field. The journal also focuses on drug analysis and analytical methodology and instrumentation, in recognition of the interrelationship between analytical chemistry and pharmaceutical analysis.

Analytical Chemistry Insights seeks to be the most timely journal for those who need to be up to date with the latest and most important developments in the field. The journal offers high-speed and credible pre-production submission processing to authors. By publishing in open-access format, authors are able to communicate with the widest possible group of readers.

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Submissions, excluding editorials, letters to the editor and dedications, will be peer reviewed by two reviewers.  Reviewers are required to provide fair, balanced and constructive reports.  

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As of April 7 2008, the US NIH Public Access Policy requires that all peer reviewed articles resulting from research carried out with NIH funding be deposited in the Pubmed Central archive.

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ISSN: 1177-3901


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Understanding Structural Features of Microbial Lipases—An Overview

Authors: John Geraldine Sandana Mala and Satoru Takeuchi
Publication Date: 27 Mar 2008
Analytical Chemistry Insights 2008:3 9-19

John Geraldine Sandana Mala1 and Satoru Takeuchi2

1SANDANA FLORALS, Module-7, Golden Jubilee Biotech Park for Women Society, In SIPCOT-IT Park, Old Mahabalipuram Road, Siruseri, Navalur P.O., Kanchipuram District-603103, Tamilnadu, India. 2Factory of Takeuchi Nenshi, TAKENEN, 85 NE, Takamatsu, Kahoku, Ishikawa 929-1215, Japan.

Abstract

The structural elucidations of microbial lipases have been of prime interest since the 1980s. Knowledge of structural features plays an important role in designing and engineering lipases for specific purposes. Significant structural data have been presented for few microbial lipases, while, there is still a structure-deficit, that is, most lipase structures are yet to be resolved. A search for ‘lipase structure’ in the RCSB Protein Data Bank (http://www.rcsb.org/pdb/) returns only 93 hits (as of September 2007) and, the NCBI database (http://www.ncbi.nlm.nih.gov) reports 89 lipase structures as compared to 14719 core nucleotide records. It is therefore worthwhile to consider investigations on the structural analysis of microbial lipases. This review is intended to provide a collection of resources on the instrumental, chemical and bioinformatics approaches for structure analyses. X-ray crystallography is a versatile tool for the structural biochemists and is been exploited till today. The chemical methods of recent interests include molecular modeling and combinatorial designs. Bioinformatics has surged striking interests in protein structural analysis with the advent of innumerable tools. Furthermore, a literature platform of the structural elucidations so far investigated has been presented with detailed descriptions as applicable to microbial lipases. A case study of Candida rugosa lipase (CRL) has also been discussed which highlights important structural features also common to most lipases. A general profi le of lipase has been vividly described with an overview of lipase research reviewed in the past.



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