Clinical Medicine: Therapeutics
Synopsis: An open access, peer reviewed electronic journal that covers therapeutics in human clinical medicine.
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Benefits of ACE Inhibitors in Diabetes
Authors: Maria E. Ramos-Nino and Steven R. Blumen
Publication Date: 14 Aug 2009
Clinical Medicine: Therapeutics 2009:1 1041-1051
Maria E. Ramos-Nino1 and Steven R. Blumen2
1Department of Pathology, University of Vermont College of Medicine, and 2Department of Medical Laboratory and Radiation Sciences, University of Vermont, Burlington, VT 05405.
Abstract
Angiotensin-converting enzyme (ACE) inhibitors have been FDA-approved for treating refractory hypertension since 1981. Since then, clinical investigations support the benefits of ACE inhibition (ACE‑I) in pathologies like congestive heart failure, myocardial infarction, diabetes mellitus, chronic renal insufficiency, and atherosclerotic cardiovascular disease. Both, clinical trials and animal models of type I and type II diabetes have shown that hyperactivity of the angiotensin II signaling pathway contributes to the development of diabetes and its complications, and that blockade of the renin‑angiotensin system prevents new onset diabetes and reduces the risk of diabetic complications. Furthermore, ACE inhibitors are generally well tolerated and have few contraindications. This article describes ACE as a target molecule and gives an overview on the clinical evidence that supports the use of ACE inhibitors in diabetes.
Keywords: ACE inhibitor, renin-angiotensin system, ACE, diabetes
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