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Clinical Medicine: Therapeutics

Synopsis: An open access, peer reviewed electronic journal that covers therapeutics in human clinical medicine.


Indexing: 2 major databases.  Pubmed indexing for NIH-funded research.

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About this journal

ISSN: 1179-1713



Aims and scope:

Clinical Medicine: Therapeutics focuses on the role of therapeutics in human clinical medicine.

Editorial standards and procedures:

Submissions, excluding editorials, letters to the editor and dedications, will be peer reviewed by two reviewers.  Reviewers are required to provide fair, balanced and constructive reports.  

Under our Fairness in Peer Review Policy authors may appeal against reviewers' recommendations which are ill-founded, unobjective or unfair.  Appeals are considered by the Editor in Chief or Associate Editor.

Papers are not sent to peer reviewers following submission of a revised manuscript. Editorial decisions on re-submitted papers are based on the author's response to the initial peer review report.

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This journal is indexed by:

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  • OAIster

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As of April 7 2008, the US NIH Public Access Policy requires that all peer reviewed articles resulting from research carried out with NIH funding be deposited in the Pubmed Central archive.

If you are an NIH employee or grantee Libertas Academica will ensure that you comply with the policy by depositing your paper at Pubmed Central on your behalf. 



 
 
 


Treatment Options in Smoking Cessation: What Place  for Bupropion Sustained-Release?

Authors: Danielle E McCarthy, Douglas E Jorenby, Haruka Minami and Vivian Yeh
Publication Date: 30 Jun 2009
Clinical Medicine: Therapeutics 2009:1 683-696

Danielle E McCarthy1, Douglas E Jorenby2, Haruka Minami1 and Vivian Yeh1

1Department of Psychology, Rutgers, The State University of New Jersey, Piscataway, NJ, USA. 2Department of Medicine and Center for Tobacco Research and Intervention, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.

Abstract

Bupropion SR is approved for the treatment of tobacco dependence in adult smokers. Bupropion SR is an atypical antidepressant that has been shown to double the likelihood of quitting smoking (to roughly 19%-24% six months into a quit attempt), perhaps by acting on dopaminergic and noradrenergic systems and by acting as an antagonist of nicotine acetylcholine receptors. Head-to-head comparisons of bupropion SR and other stop-smoking treatments suggest that bupropion SR is as or more efficacious than nicotine replacement therapies, equally efficacious as nortriptyline, and less efficacious than varenicline. The evidence available regarding the effectiveness of bupropion SR in real-world settings suggests that abstinence rates are similar to those seen in controlled clinical trials. Bupropion SR appears to be safe and efficacious for both men and women and for people with comorbid medical or mental health conditions. Evidence collected to date supports the use of bupropion SR as a safe, tolerable pharmacotherapy for smoking cessation among adult smokers without a predisposition to seizures, but also suggests that benefits in terms of abstinence last only as long as treatment continues. This review focuses on recent evidence regarding bupropion SR effects and highlights important questions regarding the duration of effects, relative efficacy, effectiveness in clinical use, mechanisms of action, and utilization of bupropion SR that remain unanswered.



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