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Joint Variable Selection and Classification with Immunohistochemical Data

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Libertas Analytics


3648 Article Views

Publication Date: 22 Jul 2009

Journal: Biomarker Insights

Citation: Biomarker Insights 2009:4 103-110

BMI journal

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6,770,712 Libertas Article Views

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Abstract

To determine if candidate cancer biomarkers have utility in a clinical setting, validation using immunohistochemical methods is typically done. Most analyses of such data have not incorporated the multivariate nature of the staining profiles. In this article, we consider modelling such data using recently developed ideas from the machine learning community. In particular, we consider the joint goals of feature selection and classification. We develop estimation procedures for the analysis of immunohistochemical profiles using the least absolute selection and shrinkage operator. These lead to novel and flexible models and algorithms for the analysis of compositional data. The techniques are illustrated using data from a cancer biomarker study.


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