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The Physiological Action of Picolinic Acid in the Human Brain

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Publication Date: 28 Apr 2009

Type: Review

Journal: International Journal of Tryptophan Research

Citation: International Journal of Tryptophan Research 2009:2 71-79

Abstract

Picolinic Acid is an endogenous metabolite of L-tryptophan (TRP) that has been reported to possess a wide range of neuroprotective, immunological, and anti-proliferative affects within the body. However the salient physiological function of this molecule is yet to be established. The synthesis of picolinic acid as a product of the kynurenine pathway (KP) suggests that, similar to other KP metabolites, picolinic acid may play a role in the pathogenesis of inflammatory disorders within the CNS and possibly other organs.

In this paper we review the limited body of literature dealing with the physiological actions of picolinic acid in the CNS and its associated synthesis via the kynurenine pathway in health and disease. Discrepancies and gaps in our current knowledge of picolinic acid are identified highlighting areas of research to promote a more complete understanding of its endogenous function in the brain.


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What Your Colleagues Say About International Journal of Tryptophan Research
This is my second publication in Int J Tryptophan Res and my experience on this occasion was as great and enjoyable as with my first paper immediately preceding this one.  I commend the Editors and the Editorial Staff of this new and exciting journal for their professionalism and dedication to science and scientific publishing.
Professor Abdulla Badawy (University of Wales Institute Cardiff, Wales, UK)
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