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RNA Processing and mRNA Surveillance in Monogenic Diabetes

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2978 Article Views

Publication Date: 21 May 2008

Journal: Gene Regulation and Systems Biology

Citation: Gene Regulation and Systems Biology 2008:2 203-212

GRSB journal

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6,654,406 Libertas Article Views

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Jonathan M. Locke and Lorna W. Harries

Institute of Biomedical and Clinical Sciences, Peninsula Medical School, Exeter, UK

Abstract

In the eukaryotic cell a number of molecular mechanisms exist to regulate the nature and quantity of transcripts intended for translation. For monogenic diabetes an understanding of these processes is aiding scientists and clinicians in studying and managing this disease. Knowledge of RNA processing and mRNA surveillance pathways is helping to explain disease mechanisms, form genotype-phenotype relationships, and identifying new regions within genes to screen for mutations. Furthermore, recent insights into the regulatory role of micro RNAs (miRNAs) and RNA editing in the pancreas suggests that these mechanisms may also be important in the progression to the diabetic state.


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