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Enantioselective Gas Chromatographic Separation of Racemic N-alkylated Barbiturates: Application of C11-Chirasil-Dex as Chiral Stationary Phase in GC

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Publication Date: 18 Sep 2007

Journal: Analytical Chemistry Insights

Citation: Analytical Chemistry Insights 2007:2 75-80

Ashraf Ghanem

Biomedicinal Chemistry Unit, Biological and Medical Research Department, King Faisal Specialist Hospital and Research Centre, (MBC-03-95), P.O. Box 3354, Riyadh 11211, Saudi Arabia.

Dedication: Dedicated to Professor Volker Schurig on the Occasion of his birthday.

Abstract: Chirasil-β-Dex containing an undecamethylene spacer (C11-Chirasil-Dex) was synthesized and used as chiral stationary phase (CSP) in enantioselective gas chromatography (GC). The versatility of the new stationary phase in the simultaneous enantiomeric separation of a set of N-alkylated barbiturates is demonstrated.


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