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Abstract Terry M.Therneau and Karla V.Ballman
Division of Biostatistics, Mayo Clinic College of Medicine, Rochester, MN 55905, U.S.A.
Abstract
Motivation: Our goal was to understand why the PLIER algorithm performs so well given its derivation is based on a biologically implausible assumption.
Results: In spite of a non-intuitive assumption regarding the PM and MM errors made as part of the derivation for PLIER, the resulting probe level error function does capture the key characteristics of the ideal error function, assuming MM probes only measure non-specific binding and no signal.
Discussion 
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I had an excellent experience publishing our review article in Clinical Medicine Reviews. The managing editor was very helpful and the process was very timely and transparent.Professor Jonathan A. Bernstein (University of Cincinnati College of Medicine, Division of Immunology, Allergy Section, Cincinnati, OH, USA) What our authors say
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