¹Genome Sciences Centre, British Columbia Cancer Research Centre, Vancouver, BC, Canada. ²Department of Gynaecologic Oncology, British Columbia Cancer Agency, Vancouver, BC, Canada. ³Cancer Imaging, British Columbia Cancer Research Centre, Vancouver, BC, Canada. ⁴Cervical Cancer Screening Program, British Columbia Cancer Agency, Vancouver, BC, Canada. ⁵Cancer Genetics and Developmental Biology, British Columbia Cancer Research Centre, Vancouver, BC, Canada. ⁶Biomedical Engineering, University of Texas at Austin, Austin, TX, U.S.A. ⁷University of Texas M.D. Anderson Cancer Center, Department of Gynecologic Oncology and Biomedical Engineering Center, Houston, TX, U.S.A.

Abstract: Sixteen longSAGE libraries from four different clinical stages of cervical intraepithelial neoplasia have enabled us to identify novel cell-surface biomarkers indicative of CIN stage. By comparing gene expression profiles of cervical tissue at early and advanced stages of CIN, several genes are identified to be novel genetic markers. We present fifty-six cell-surface gene products differentially expressed during progression of CIN. These cell surface proteins are being examined to establish their capacity for optical contrast agent binding. Contrast agent visualization will allow real-time assessment of the physiological state of the disease process bringing vast benefi t to cancer care. The data discussed in this publication have been submitted to NCBIs Gene Expression Omnibus (GEO, http://www.ncbi.nlm.nih.gov/geo/) and are accessible through GEO Series accession number GSE6252.

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