Clinical Medicine Insights: Dermatology

Nevoid hyperkeratosis of the breast is a rare condition affecting the nipple, the areola, or both. Different therapeutic options have been used with varying results, but there is no uniformly effective treatment. We report a case of nevoid hyperkeratosis of the nipple in a woman presenting with thickening and hyperpigmentation of both nipples for 15 years. Histologic examination confirmed the diagnosis of nevoid hyperkeratosis. The patient was successfully managed by topical calcipotriol. Calcipotriol is an effective therapeutic option in nevoid hyperkeratosis of the nipple and shows rapid outcome.