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Breast Cancer: Basic and Clinical Research

Synopsis: An open access, peer reviewed electronic journal that covers all areas of breast cancer research and treatment.


Indexing: 3 major databases. Pubmed indexing for NIH-funded research.

Processing time: Decision in 2 weeks for 90% of papers.

Visibility: Most popular article read 900+ times.

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About this journal

ISSN: 1178-2234


Aims and scope:

Breast Cancer: Basic and Clinical Research is an international, open access, peer reviewed journal which considers manuscripts on all areas of breast cancer research and treatment. These areas include: breast cancer biology and pathogenesis, clinical interventions, and epidemiology and population genetics.

Editorial standards and procedures:

Submissions, excluding editorials, letters to the editor and dedications, will be peer reviewed by two reviewers.  Reviewers are required to provide fair, balanced and constructive reports.  

Under our Fairness in Peer Review Policy authors may appeal against reviewers' recommendations which are ill-founded, unobjective or unfair.  Appeals are considered by the Editor in Chief or Associate Editor.

Papers are not sent to peer reviewers following submission of a revised manuscript. Editorial decisions on re-submitted papers are based on the author's response to the initial peer review report.

Indexing:

This journal is indexed by:

  • Google Scholar
  • CAS
  • DOAJ

SPARC Europe Seal award winner:

This journal has been awarded a SPARC Europe Seal. The Seal is an initiative of SPARC Europe (Scholarly Publishing and Academic Resources Coalition) and the Directory of Open Access Journals (DOAJ) which is awarded to journals applying a Creative Commons CC-BY copyright license and that make journal metadata accessible to DOAJ.  

Amongst other important services DOAJ makes metadata OAI-compliant.  This in turn enhances the visibility of papers and allows OAI-harvesters to include the details of journal articles in their services. We encourage readers to make use of this valuable resource.  The DOAJ search page is available here.

National Institutes of Health Public Access Policy compliant:

As of April 7 2008, the US NIH Public Access Policy requires that all peer reviewed articles resulting from research carried out with NIH funding be deposited in the Pubmed Central archive.

If you are an NIH employee or grantee Libertas Academica will ensure that you comply with the policy by depositing your paper at Pubmed Central on your behalf. 



Editor in Chief's call for papers
 
 
 


Quality of Life and Neutropenia in Patients with Early Stage Breast Cancer: A Randomized Pilot Study Comparing Additional Treatment with Mistletoe Extract to Chemotherapy alone. (Provisional PDF)

Authors: Wilfried Tröger, Svetlana Jezdić, Zdravko Ždrale, Nevena Tišma, Harald J. Hamre, Miodrag Matijašević
Publication Date: 18 Jun 2009
Breast Cancer: Basic and Clinical Research 2009:3

Wilfried Tröger1, Svetlana Jezdić2, Zdravko Ždrale2, Nevena Tišma2, Harald J. Hamre3, Miodrag Matijašević2

1Clinical Research Dr. Tröger, Freiburg, Germany. 2Institute of Oncology and Radiology of Serbia, Belgrade, Yugoslavia. 3Institute for Applied Epistemology and Medical Methodology, Freiburg, Germany.

Abstract

Background: Chemotherapy for breast cancer often deteriorates quality of life, augments fatigue, and induces neutropenia. Mistletoe preparations are frequently used by cancer patients in Central Europe. Physicians have reported better quality of life in breast cancer patients additionally treated with mistletoe preparations during chemotherapy. Mistletoe preparations also have immunostimulant properties and might therefore have protective effects against chemotherapy-induced neutropenia.

Patients and Methods: We conducted a prospective randomized open label pilot study with 95 patients randomized into three groups. Two groups received Iscador® M special (IMS) or a different mistletoe preparation, respectively, additionally to chemotherapy with six cycles of cyclophosphamide, adriamycin, and 5-fluoro-uracil (CAF). A control group received CAF with no additional therapy. Here we report the comparison IMS (n=30) vs. control (n=31). Quality of life including fatigue was assessed with the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC-QLQ-C30). Neutropenia was defined as neutrophil counts <1,000/µl and assessed at baseline and one day before each CAF cycle.

Results: In the descriptive analysis all 15 scores of the EORTC-QLQ-C30 showed better quality of life in the IMS group compared to the control group. In 12 scores the differences were significant (p<0.02) and nine scores showed a clinically relevant and significant difference of at least 5 points.
Neutropenia occurred in 3/30 IMS patients and in 8/31 control patients (p=0.182).

Conclusions: This pilot study showed an improvement of quality of life by treating breast cancer patients with IMS additionally to CAF. CAF-induced neutropenia showed a trend to lower frequency in the IMS group.

Categories: Cancer , Womens' health


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